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Gene Review

SNAP29  -  synaptosomal-associated protein, 29kDa

Homo sapiens

Synonyms: CEDNIK, SNAP-29, Soluble 29 kDa NSF attachment protein, Synaptosomal-associated protein 29, Vesicle-membrane fusion protein SNAP-29
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Disease relevance of SNAP29


High impact information on SNAP29


Biological context of SNAP29


Anatomical context of SNAP29

  • These findings suggest that SNAP-29 acts as a negative modulator for neurotransmitter release, probably by slowing recycling of the SNARE-based fusion machinery and synaptic vesicle turnover [2].
  • While SNAP-23 preferentially binds to plasma membrane-localized syntaxins, SNAP-29 binds to both plasma membrane and intracellular syntaxins equally well [6].
  • On intracellular organelles that serve as targets for transport vesicles, organelle-specific syntaxins form heterodimers with either SNAP-23 or its recently described homolog SNAP-29 [6].

Other interactions of SNAP29

  • Furthermore, studies on both SNAP-25 and its non-palmitoylated homologues SNAP-29 and sec9, have suggested an alternative or complementary mechanism for membrane association involving interaction with syntaxin [7].


  1. A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma. Sprecher, E., Ishida-Yamamoto, A., Mizrahi-Koren, M., Rapaport, D., Goldsher, D., Indelman, M., Topaz, O., Chefetz, I., Keren, H., O'brien, T.J., Bercovich, D., Shalev, S., Geiger, D., Bergman, R., Horowitz, M., Mandel, H. Am. J. Hum. Genet. (2005) [Pubmed]
  2. SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons. Pan, P.Y., Cai, Q., Lin, L., Lu, P.H., Duan, S., Sheng, Z.H. J. Biol. Chem. (2005) [Pubmed]
  3. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. Rotem-Yehudar, R., Galperin, E., Horowitz, M. J. Biol. Chem. (2001) [Pubmed]
  4. Three novel proteins of the syntaxin/SNAP-25 family. Steegmaier, M., Yang, B., Yoo, J.S., Huang, B., Shen, M., Yu, S., Luo, Y., Scheller, R.H. J. Biol. Chem. (1998) [Pubmed]
  5. Polymorphism in SNAP29 gene promoter region associated with schizophrenia. Saito, T., Guan, F., Papolos, D.F., Rajouria, N., Fann, C.S., Lachman, H.M. Mol. Psychiatry (2001) [Pubmed]
  6. SNAP-29 is a promiscuous syntaxin-binding SNARE. Hohenstein, A.C., Roche, P.A. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells. Gonelle-Gispert, C., Molinete, M., Halban, P.A., Sadoul, K. J. Cell. Sci. (2000) [Pubmed]
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