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Gene Review

putA  -  fused DNA-binding transcriptional...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1005, JW0999, poaA, putC
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Disease relevance of putA


High impact information on putA


Biological context of putA


Anatomical context of putA

  • Membranes from a strain with a deletion of the putA gene encoding L-proline dehydrogenase or a strain with a putA::Tn5 insertion mutation had no detectable activity with either substrate [10].

Associations of putA with chemical compounds

  • In a P. putida putA-deficient background, expression of both putA and putP genes was maximal and proline independent [2].

Other interactions of putA

  • We concluded that the putC region is 419 bp long and contains two independent sets of promoters, regulating the expression of putP and putA genes in opposite directions [7].


  1. Genetic and physical characterization of putP, the proline carrier gene of Escherichia coli K12. Mogi, T., Yamamoto, H., Nakao, T., Yamato, I., Anraku, Y. Mol. Gen. Genet. (1986) [Pubmed]
  2. Proline catabolism by Pseudomonas putida: cloning, characterization, and expression of the put genes in the presence of root exudates. Vílchez, S., Molina, L., Ramos, C., Ramos, J.L. J. Bacteriol. (2000) [Pubmed]
  3. Isolation, DNA sequence analysis, and mutagenesis of a proline dehydrogenase gene (putA) from Bradyrhizobium japonicum. Straub, P.F., Reynolds, P.H., Althomsons, S., Mett, V., Zhu, Y., Shearer, G., Kohl, D.H. Appl. Environ. Microbiol. (1996) [Pubmed]
  4. Identification and characterization of the DNA-binding domain of the multifunctional PutA flavoenzyme. Gu, D., Zhou, Y., Kallhoff, V., Baban, B., Tanner, J.J., Becker, D.F. J. Biol. Chem. (2004) [Pubmed]
  5. Sequence analysis identifies the proline dehydrogenase and delta 1-pyrroline-5-carboxylate dehydrogenase domains of the multifunctional Escherichia coli PutA protein. Ling, M., Allen, S.W., Wood, J.M. J. Mol. Biol. (1994) [Pubmed]
  6. Mapping of the multiple regulatory sites for putP and putA expression in the putC region of Escherichia coli. Nakao, T., Yamato, I., Anraku, Y. Mol. Gen. Genet. (1988) [Pubmed]
  7. Nucleotide sequence of putC, the regulatory region for the put regulon of Escherichia coli K12. Nakao, T., Yamato, I., Anraku, Y. Mol. Gen. Genet. (1987) [Pubmed]
  8. Construction of a novel hydroxyproline-producing recombinant Escherichia coli by introducing a proline 4-hydroxylase gene. Shibasaki, T., Hashimoto, S., Mori, H., Ozaki, A. J. Biosci. Bioeng. (2000) [Pubmed]
  9. Nucleotide sequence of putP, the proline carrier gene of Escherichia coli K12. Nakao, T., Yamato, I., Anraku, Y. Mol. Gen. Genet. (1987) [Pubmed]
  10. Oxidation of L-thiazolidine-4-carboxylate by L-proline dehydrogenase in Escherichia coli. Deutch, C.E. J. Gen. Microbiol. (1992) [Pubmed]
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