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Gene Review

otsA  -  trehalose-6-phosphate synthase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1895, JW5312, pexA
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Disease relevance of otsA


High impact information on otsA


Biological context of otsA

  • There is another gene locus near 84 min on the chromosome, that we termed otsR, which is involved in the regulation of otsA/B and possibly otsP [8].
  • Significantly, photosynthetic capacity (CO(2) assimilation at varying light and CO(2), and quantum yield of PSII electron transport) per unit leaf area and per leaf dry weight were increased in lines of N. tabacum transformed with the E. coli gene otsA, which encodes trehalose phosphate synthase [9].

Other interactions of otsA

  • Primer extension analysis showed only one transcription start point upstream from otsB and one upstream from otsA, regardless of the growth conditions tested [10].

Analytical, diagnostic and therapeutic context of otsA


  1. Trehalose expression confers desiccation tolerance on human cells. Guo, N., Puhlev, I., Brown, D.R., Mansbridge, J., Levine, F. Nat. Biotechnol. (2000) [Pubmed]
  2. Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures. Kandror, O., DeLeon, A., Goldberg, A.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Trehalose biosynthesis in Thermus thermophilus RQ-1: biochemical properties of the trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase. Silva, Z., Alarico, S., da Costa, M.S. Extremophiles (2005) [Pubmed]
  4. Overproduction of trehalose: heterologous expression of Escherichia coli trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in Corynebacterium glutamicum. Padilla, L., Krämer, R., Stephanopoulos, G., Agosin, E. Appl. Environ. Microbiol. (2004) [Pubmed]
  5. Structural evidence of a passive base-flipping mechanism for AGT, an unusual GT-B glycosyltransferase. Larivière, L., Sommer, N., Moréra, S. J. Mol. Biol. (2005) [Pubmed]
  6. Expression of escherichia coli otsA in a Saccharomyces cerevisiae tps1 mutant restores trehalose 6-phosphate levels and partly restores growth and fermentation with glucose and control of glucose influx into glycolysis. Bonini, B.M., Van Vaeck, C., Larsson, C., Gustafsson, L., Ma, P., Winderickx, J., Van Dijck, P., Thevelein, J.M. Biochem. J. (2000) [Pubmed]
  7. Molecular cloning and physical mapping of the otsBA genes, which encode the osmoregulatory trehalose pathway of Escherichia coli: evidence that transcription is activated by katF (AppR). Kaasen, I., Falkenberg, P., Styrvold, O.B., Strøm, A.R. J. Bacteriol. (1992) [Pubmed]
  8. The repression of trehalose transport and metabolism in Escherichia coli by high osmolarity is mediated by trehalose-6-phosphate phosphatase. Klein, W., Ehmann, U., Boos, W. Res. Microbiol. (1991) [Pubmed]
  9. Genetic modification of photosynthesis with E. coli genes for trehalose synthesis. Pellny, T.K., Ghannoum, O., Conroy, J.P., Schluepmann, H., Smeekens, S., Andralojc, J., Krause, K.P., Goddijn, O., Paul, M.J. Plant Biotechnol. J. (2004) [Pubmed]
  10. Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex. Kaasen, I., McDougall, J., Strøm, A.R. Gene (1994) [Pubmed]
  11. Directed evolution of operon of trehalose-6-phosphate synthase/phosphatase from Escherichia coli. Kong, X., Liu, Y., Gou, X., Zhang, H., Wang, X., Zhang, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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