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Chemical Compound Review

Azeserine     (Z)-1-[(2S)-2-amino-2- carboxy-ethoxy]-2...

Synonyms: Azaserin, Azaserina, azaserine, Azaserinum, L-azaserine, ...
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Disease relevance of (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium


Psychiatry related information on (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium

  • These results suggest that the reduction in the synthesis of PG-H as well as the production of an abnormal form of PG-H during a critical period of limb morphogenesis may be important factors in explaining the micromelia induced by azaserine [6].

High impact information on (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium


Chemical compound and disease context of (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium


Biological context of (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium


Anatomical context of (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium


Associations of (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium with other chemical compounds


Gene context of (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium


Analytical, diagnostic and therapeutic context of (E)-2-[(2S)-2-amino-2-carboxy-ethoxy]-2-hydroxy-ethenediazonium


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  2. Pathologic and biochemical effects of azaserine in inbred Wistar/Lewis rats and noninbred CD-1 mice. Roebuck, B.D., Lilja, H.S., Curphey, T.J., Longnecker, D.S. J. Natl. Cancer Inst. (1980) [Pubmed]
  3. Secretagogue response of azaserine-induced rat pancreatic acinar tumors in vivo. Herzig, K.H., Creutzfeldt, W., Fölsch, U.R. Gastroenterology (1991) [Pubmed]
  4. Acinar cell carcinoma of the rat pancreas grown in cell culture and in nude mice. Rao, K.N., Takahashi, S., Shinozuka, H. Cancer Res. (1980) [Pubmed]
  5. Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas. Douglas, B.R., Woutersen, R.A., Jansen, J.B., de Jong, A.J., Rovati, L.C., Lamers, C.B. Cancer Res. (1989) [Pubmed]
  6. Abnormal synthesis of cartilage-characteristic proteoglycan in azaserine-induced micromelial limbs. Honda, A., Tsuboi, I., Kimata, K., Hirabayashi, Y., Yamada, K., Mori, Y. Biochem. J. (1989) [Pubmed]
  7. High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. Kolm-Litty, V., Sauer, U., Nerlich, A., Lehmann, R., Schleicher, E.D. J. Clin. Invest. (1998) [Pubmed]
  8. Effect of dietary omega-3 and omega-6 fatty acids on development of azaserine-induced preneoplastic lesions in rat pancreas. O'Connor, T.P., Roebuck, B.D., Peterson, F.J., Lokesh, B., Kinsella, J.E., Campbell, T.C. J. Natl. Cancer Inst. (1989) [Pubmed]
  9. Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas. O'Connor, T.P., Roebuck, B.D., Peterson, F., Campbell, T.C. J. Natl. Cancer Inst. (1985) [Pubmed]
  10. Species and rat strain variation in pancreatic nodule induction by azaserine. Roebuck, B.D., Longnecker, D.S. J. Natl. Cancer Inst. (1977) [Pubmed]
  11. Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme. Kamatani, N., Nelson-Rees, W.A., Carson, D.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  12. Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy. Pang, Y., Bounelis, P., Chatham, J.C., Marchase, R.B. Diabetes (2004) [Pubmed]
  13. Role of the nucleoside transport function in the transport and salvage of purine nucleobases. Aronow, B., Ullman, B. J. Biol. Chem. (1986) [Pubmed]
  14. Effect of tetragastrin on azaserine-induced carcinogenesis in rat pancreas. Tatsuta, M., Iishi, H., Baba, M., Nakaizumi, A. Int. J. Cancer (1990) [Pubmed]
  15. Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc. Champattanachai, V., Marchase, R.B., Chatham, J.C. Am. J. Physiol., Cell Physiol. (2007) [Pubmed]
  16. Activation of a nonexpressed hypoxanthine phosphoribosyltransferase allele in mutant H23 HeLa cells by agents that inhibit DNA methylation. Ivarie, R., Morris, J.A. Mol. Cell. Biol. (1986) [Pubmed]
  17. DNA damage and repair in rat tissues following administration of azaserine. Lilja, H.S., Hyde, E., Longnecker, D.S., Yager, J.D. Cancer Res. (1977) [Pubmed]
  18. Inhibitory effects of estrogen and castration on the early stage of pancreatic carcinogenesis in Fischer rats treated with azaserine. Sumi, C., Longnecker, D.S., Roebuck, B.D., Brinck-Johnsen, T. Cancer Res. (1989) [Pubmed]
  19. Adenocarcinoma of the pancreas in azaserine-treated rats. Longnecker, D.S., Curphey, T.J. Cancer Res. (1975) [Pubmed]
  20. Dietary modulation of pancreatic carcinogenesis: calories and energy expenditure. Craven-Giles, T., Tagliaferro, A.R., Ronan, A.M., Baumgartner, K.J., Roebuck, B.D. Cancer Res. (1994) [Pubmed]
  21. Response of two rodents, Mastomys natalensis and Mystromys albicaudatus, to the pancreatic carcinogen azaserine. Roebuck, B.D., Longnecker, D.S. J. Natl. Cancer Inst. (1979) [Pubmed]
  22. Photoinhibition of 2-amino-2-carboxybicyclo[2,2,1]heptane transport by O-diazoacetyl-L-serine. An initial step in identifying the L-system amino acid transporter. Segel, G.B., Woodlock, T.J., Murant, F.G., Lichtman, M.A. J. Biol. Chem. (1989) [Pubmed]
  23. Influence of cholecystokinin antagonist on the effects of cholecystokinin and bombesin on azaserine-induced lesions in rat pancreas. Douglas, B.R., Woutersen, R.A., Jansen, J.B., de Jong, A.J., Rovati, L.C., Lamers, C.B. Gastroenterology (1989) [Pubmed]
  24. Inhibition of pancreatic carcinogenesis by retinoids in azaserine-treated rats. Longnecker, D.S., Curphey, T.J., Kuhlmann, E.T., Roebuck, B.D. Cancer Res. (1982) [Pubmed]
  25. Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C. Singh, L.P., Andy, J., Anyamale, V., Greene, K., Alexander, M., Crook, E.D. Diabetes (2001) [Pubmed]
  26. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. Marshall, S., Bacote, V., Traxinger, R.R. J. Biol. Chem. (1991) [Pubmed]
  27. Novel expression of gastrin (cholecystokinin-B) receptors in azaserine-induced rat pancreatic carcinoma: receptor determination and characterization. Zhou, W., Povoski, S.P., Longnecker, D.S., Bell, R.H. Cancer Res. (1992) [Pubmed]
  28. Overexpression of messenger RNA for cholecystokinin-A receptor and novel expression of messenger RNA for gastrin (cholecystokinin-B) receptor in azaserine-induced rat pancreatic carcinoma. Zhou, W., Povoski, S.P., Bell, R.H. Carcinogenesis (1993) [Pubmed]
  29. YfiK from Escherichia coli promotes export of O-acetylserine and cysteine. Franke, I., Resch, A., Dassler, T., Maier, T., Böck, A. J. Bacteriol. (2003) [Pubmed]
  30. Dissimilar effect of the carcinogenic agent azaserine on pancreatic and hepatic polyamine metabolism in rats. Löser, C., Stüber, E., Fölsch, U.R. Pancreas (1995) [Pubmed]
  31. Animal model of human disease. Carcinoma of the pancreas in azaserine-treated rats. Longnecker, D.S. Am. J. Pathol. (1981) [Pubmed]
  32. Gut peptide receptors in pancreata of azaserine-treated and normal control rats. Tang, C., Biemond, I., Appel, M.J., Visser, C.J., Woutersen, R.A., Lamers, C.B. Carcinogenesis (1995) [Pubmed]
  33. Effects of sandostatin, alone and in combination with surgical castration, on pancreatic carcinogenesis in rats and hamsters. Visser, C.J., van Garderen-Hoetmer, A., Klijn, J.G., Foekens, J.A. Int. J. Cancer (1996) [Pubmed]
  34. Modulation of growth and cell turnover of preneoplastic lesions and of prostaglandin levels in rat pancreas by dietary fish oil. Appel, M.J., Woutersen, R.A. Carcinogenesis (1994) [Pubmed]
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