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Gene Review

acs  -  acetyl-CoA synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4062, JW4030, acsA, yfaC
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Disease relevance of acs


High impact information on acs

  • The acsA gene product expressed in Escherichia coli showed acyl-CoA synthetase activity toward butyric acid and CoA as substrates, with butyryl-CoA being synthesized [2].
  • On the basis of these results, we propose that cells induce acs, and thus their ability to assimilate acetate, in response to rising cyclic AMP levels, falling oxygen partial pressure, and the flux of carbon through acetate-associated pathways [3].
  • Relative to wild-type cells, those deleted for acs did not activate acetate as well, those deleted for ackA and pta displayed even less activity, and those deleted for all three genes did not activate acetate at any concentration tested [1].
  • Expression of acs from a multicopy plasmid restored growth to cells deleted for all three genes [1].
  • We constructed a mutant allele, delta acs::Km, with the central 0.72-kb BclI-BclI portion of acs deleted, and recombined it into the chromosome [1].

Biological context of acs


Associations of acs with chemical compounds


Other interactions of acs

  • The transcript of acs is higher in E. coli BL21 and lower in the E. coli JM109, while the reverse is true for poxB transcription [6].


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