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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Partial Pressure

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Disease relevance of Partial Pressure


Psychiatry related information on Partial Pressure

  • During desynchronized sleep ventilation increases and becomes very irregular but the partial pressure of O2 and CO2 in arterial blood is little changed from wakefulness [6].
  • This is consistent with the result of catalytic wet air oxidation of phenol and the COD removal can be arrived at 98.2% at temperature 210 degrees C, oxygen partial pressure 3 MPa and reaction time 30 min [7].

High impact information on Partial Pressure

  • The mean partial pressure of oxygen in 33 patients was 78 mm Hg at entry and 93 mm Hg after the course of 566C80 (P less than 0.001) [8].
  • For example, low 13C/12C in Cretaceous sediments has been attributed to elevated atmospheric (and hence oceanic) CO2 partial pressures [9].
  • The response to anaesthetics is completely reversible and saturates at low anaesthetic partial pressures: the half-maximal response for halothane occurs at 0.0063 atm, close to its minimum alveolar concentration (0.0075 atm) in man [10].
  • We report on suppression of chemical turbulence by global delayed feedback using, as an example, catalytic carbon monoxide oxidation on a platinum (110) single-crystal surface and carbon monoxide partial pressure as the controlled feedback variable [11].
  • Although C4 plant expansions have been recognized in the late Miocene, identification of the underlying causes is complicated by the uncertainties associated with estimates of ancient precipitation, temperature, and partial pressure of atmospheric carbon dioxide (PCO2) [12].

Chemical compound and disease context of Partial Pressure


Biological context of Partial Pressure


Anatomical context of Partial Pressure

  • Neohemocytes are substantially smaller than erythrocytes, contain 15.1 grams per decaliter of hemoglobin, and have a P50 value (the partial pressure of oxygen at which the hemoglobin is half-saturated) of 24.0 torr [23].
  • In common duct bile, observed ranges were as follows: pH, 7.37-7.85; CO2 partial pressure (PCO2), 21-32 mmHg; total CO2 concentration ([TCO2]), 16.4-41.4 mM; total bile salt concentration ([TBS]), 16-93 mM; and [Na], 153-192 mM [24].
  • To test this hypothesis, we examined the effect of exposure to high partial pressures of O2 or NO2 on the physical state and function of pulmonary endothelial cell plasma membranes [25].
  • METHODS: Monkey and dog cerebral arterial strips with endothelium were suspended for isometric tension recording in Ringer-Locke solution aerated with 95% O2-5% CO2 (partial pressure, 570-600 mm Hg) or 95% N2-5% CO2 (approximately 10 mm Hg) [26].
  • Within skeletal muscle the extent to which myoglobin desaturates (deoxy-Mb) and the extent of this desaturation in relation to O2 availability provide an endogenous probe for intracellular O2 partial pressure (P(iO2)) [27].

Associations of Partial Pressure with chemical compounds


Gene context of Partial Pressure

  • Partial pressure of oxygen (PaO2) levels in the hIL-10 group (6 hr of CIT) were higher than in empty vector and diluent groups (PaO2, 530 +/- 23 vs. 387 +/- 31 and 439 +/- 27 mmHg, respectively, p < 0.05) [32].
  • In these patients plasma elastase and serum IL-6 levels subsequently increased while the ratio of arterial partial pressure of oxygen to fraction inspired oxygen decreased, and they developed bilateral lung infiltration on chest radiography on days 3-7 [33].
  • In contrast, there was no correlation between MMP-1 and/or MMP-3 expression and impairment in gas exchange, as determined by the ratio of partial pressure of oxygen to fraction of inspired oxygen (Pao(2)/Fio(2)) on the day of BAL sample [34].
  • On the other hand, HIF-1alpha cannot be detected above a critical partial pressure of oxygen when it is subjected to rapid ubiquitinylation and proteasomal degradation [35].
  • The inhibition of Epo production at low partial pressures of oxygen by carbon monoxide provides evidence that a heme protein is integrally involved in the oxygen-sensing mechanism [36].

Analytical, diagnostic and therapeutic context of Partial Pressure


  1. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. Glaser, N., Barnett, P., McCaslin, I., Nelson, D., Trainor, J., Louie, J., Kaufman, F., Quayle, K., Roback, M., Malley, R., Kuppermann, N. N. Engl. J. Med. (2001) [Pubmed]
  2. Kinetic mechanism of acetyl-CoA synthase: steady-state synthesis at variable Co/Co2 pressures. Maynard, E.L., Sewell, C., Lindahl, P.A. J. Am. Chem. Soc. (2001) [Pubmed]
  3. Long-term effects of hydralazine on ventilation and blood gas values in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Corriveau, M.L., Vu-Dinh Minh, n.u.l.l., Dolan, G.F. Am. J. Med. (1987) [Pubmed]
  4. Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Collard, H.R., King, T.E., Bartelson, B.B., Vourlekis, J.S., Schwarz, M.I., Brown, K.K. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  5. Life-long impairment of hypoxic phrenic responses in rats following 1 month of developmental hyperoxia. Fuller, D.D., Bavis, R.W., Vidruk, E.H., Wang, Z.Y., Olson, E.B., Bisgard, G.E., Mitchell, G.S. J. Physiol. (Lond.) (2002) [Pubmed]
  6. Respiratory and circulatory control during sleep. Coote, J.H. J. Exp. Biol. (1982) [Pubmed]
  7. Kinetics study on catalytic wet air oxidation of phenol by several metal oxide catalysts. Wan, J.F., Feng, Y.J., Cai, W.M., Yang, S.X., Sun, X.J. Journal of environmental sciences (China). (2004) [Pubmed]
  8. A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome. Falloon, J., Kovacs, J., Hughes, W., O'Neill, D., Polis, M., Davey, R.T., Rogers, M., LaFon, S., Feuerstein, I., Lancaster, D. N. Engl. J. Med. (1991) [Pubmed]
  9. Latitudinal variations in plankton delta 13C: implications for CO2 and productivity in past oceans. Rau, G.H., Takahashi, T., Des Marais, D.J. Nature (1989) [Pubmed]
  10. Volatile general anaesthetics activate a novel neuronal K+ current. Franks, N.P., Lieb, W.R. Nature (1988) [Pubmed]
  11. Controlling chemical turbulence by global delayed feedback: pattern formation in catalytic CO oxidation on Pt(110). Kim, M., Bertram, M., Pollmann, M., von Oertzen , A., Mikhailov, A.S., Rotermund, H.H., Ertl, G. Science (2001) [Pubmed]
  12. Climate change as the dominant control on glacial-interglacial variations in C3 and C4 plant abundance. Huang, Y., Street-Perrott, F.A., Metcalfe, S.E., Brenner, M., Moreland, M., Freeman, K.H. Science (2001) [Pubmed]
  13. Dose-dependent effects of halothane on the phrenic nerve responses to acute hypoxia in vagotomized dogs. Stuth, E.A., Dogas, Z., Krolo, M., Kampine, J.P., Hopp, F.A., Zuperku, E.J. Anesthesiology (1997) [Pubmed]
  14. Cardiovascular actions of nitrous oxide or halothane in hypovolemic swine. Weiskopf, R.B., Bogetz, M.S. Anesthesiology (1985) [Pubmed]
  15. Acute hypoxia increases S100beta protein in association with blood flow redistribution away from peripheral circulations in fetal sheep. Giussani, D.A., Thakor, A.S., Frulio, R., Gazzolo, D. Pediatr. Res. (2005) [Pubmed]
  16. Automated detection of gastric luminal partial pressure of carbon dioxide during cardiovascular surgery using the Tonocap. Bennett-Guerrero, E., Panah, M.H., Bodian, C.A., Methikalam, B.J., Alfarone, J.R., DePerio, M., Mythen, M.G. Anesthesiology (2000) [Pubmed]
  17. Changes in tumor oxygenation during a combined treatment with fractionated irradiation and hyperthermia: an experimental study. Zywietz, F., Reeker, W., Kochs, E. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]
  18. The effects of red blood cell infusion on 10-km race time. Brien, A.J., Simon, T.L. JAMA (1987) [Pubmed]
  19. Inert gas analysis of ventilation-perfusion matching during hemodialysis. Ralph, D.D., Ott, S.M., Sherrard, D.J., Hlastala, M.P. J. Clin. Invest. (1984) [Pubmed]
  20. Effects of protriptyline on diurnal and nocturnal oxygenation in patients with chronic obstructive pulmonary disease. Sériès, F., Cormier, Y. Ann. Intern. Med. (1990) [Pubmed]
  21. Lactic acidosis in severe asthma. Appel, D., Rubenstein, R., Schrager, K., Williams, M.H. Am. J. Med. (1983) [Pubmed]
  22. Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: effects of oxygen partial pressure. Palozza, P., Luberto, C., Calviello, G., Ricci, P., Bartoli, G.M. Free Radic. Biol. Med. (1997) [Pubmed]
  23. Synthesis and evaluation of a prototypal artificial red cell. Hunt, C.A., Burnette, R.R., MacGregor, R.D., Strubbe, A.E., Lau, D.T., Taylor, N., Kiwada, H. Science (1985) [Pubmed]
  24. Evidence for H+ secretion by the in vivo canine gallbladder. Rege, R.V., Moore, E.W. Gastroenterology (1987) [Pubmed]
  25. The effect of oxidant gases on membrane fluidity and function in pulmonary endothelial cells. Patel, J.M., Block, E.R. Free Radic. Biol. Med. (1988) [Pubmed]
  26. Potentiation by hypoxia of contractions caused by angiotensin II in dog and monkey cerebral arteries. Yoshida, K., Okamura, T., Toda, N. Stroke (1993) [Pubmed]
  27. Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability. Richardson, R.S., Duteil, S., Wary, C., Wray, D.W., Hoff, J., Carlier, P.G. J. Physiol. (Lond.) (2006) [Pubmed]
  28. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Ghofrani, H.A., Wiedemann, R., Rose, F., Schermuly, R.T., Olschewski, H., Weissmann, N., Gunther, A., Walmrath, D., Seeger, W., Grimminger, F. Lancet (2002) [Pubmed]
  29. Reevaluation of chloride's regulation of hemoglobin oxygen uptake: the neglected contribution of protein hydration in allosterism. Colombo, M.F., Rau, D.C., Parsegian, V.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  30. Tamoxifen induces hypoxia in MCF-7 xenografts. Evans, S.M., Koch, C.J., Laughlin, K.M., Jenkins, W.T., Van Winkle, T., Wilson, D.F. Cancer Res. (1997) [Pubmed]
  31. Peroxyl radical scavenging by beta-carotene in lipid bilayers. Effect of oxygen partial pressure. Kennedy, T.A., Liebler, D.C. J. Biol. Chem. (1992) [Pubmed]
  32. In vivo transtracheal adenovirus-mediated transfer of human interleukin-10 gene to donor lungs ameliorates ischemia-reperfusion injury and improves early posttransplant graft function in the rat. Fischer, S., Liu, M., MacLean, A.A., de Perrot, M., Ho, M., Cardella, J.A., Zhang, X.M., Bai, X.H., Suga, M., Imai, Y., Keshavjee, S. Hum. Gene Ther. (2001) [Pubmed]
  33. Relation between tumour necrosis factor alpha and interleukin 1beta producing capacity of peripheral monocytes and pulmonary complications following oesophagectomy. Katsuta, T., Saito, T., Shigemitsu, Y., Kinoshita, T., Shiraishi, N., Kitano, S. The British journal of surgery. (1998) [Pubmed]
  34. Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury. Fligiel, S.E., Standiford, T., Fligiel, H.M., Tashkin, D., Strieter, R.M., Warner, R.L., Johnson, K.J., Varani, J. Hum. Pathol. (2006) [Pubmed]
  35. Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy. Hofer, T., Desbaillets, I., Höpfl, G., Wenger, R.H., Gassmann, M. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2002) [Pubmed]
  36. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Goldberg, M.A., Dunning, S.P., Bunn, H.F. Science (1988) [Pubmed]
  37. Intracellular pH during reperfusion influences evoked potential recovery after complete cerebral ischemia. Maruki, Y., Koehler, R.C., Eleff, S.M., Traystman, R.J. Stroke (1993) [Pubmed]
  38. Effects of defibrination on hemorheology, cerebral blood flow velocity, and CO2 reactivity during hypocapnia in normal subjects. Izumi, Y., Tsuda, Y., Ichihara, S., Takahashi, T., Matsuo, H. Stroke (1996) [Pubmed]
  39. Dependence of mitochondrial and cytosolic adenine nucleotides on oxygen partial pressure in isolated hepatocytes. Application of a new rapid high pressure filtration technique for fractionation. Hummerich, H., de Groot, H., Noll, T., Soboll, S. Biochem. J. (1988) [Pubmed]
  40. Alteration of tissue oxygen partial pressure during isolated, hyperthermic limb perfusion with cytostatic drugs or recombinant human tumor necrosis factor alpha combined with melphalan. Hohenberger, P., Bida, B., Schlag, P.M. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1996) [Pubmed]
  41. Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation. Albanèse, J., Arnaud, S., Rey, M., Thomachot, L., Alliez, B., Martin, C. Anesthesiology (1997) [Pubmed]
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