Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

mviN - virulence factor

Haemophilus influenzae Rd KW20

Liaw, S.J. et al., Sáez-Llorens, X. et al., Campbell, H. et al., Lindberg, A.A., Müller, A. et al., et al.

Buttery, Moxon,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of mviN

Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media [1].
Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae [2].
Serum antibodies to the polyribosylribitol phosphate (PRP) capsule, the main virulence factor of Hib, are protective, but the early vaccines containing purified PRP were poorly immunogenic in young children [3].
Pertussis toxin is an important virulence factor of Bordetella pertussis that may also contribute to the toxicity of pertussis vaccines [4].
The polysaccharide capsule which surrounds bacterial species like Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, Salmonella typhi, is a potent virulence factor [5].

High impact information on mviN

The implications of these findings as regards the role of lipopolysaccharide as a virulence factor are discussed [6].
This plasmid was thought to code for a virulence factor because it had been detected only among Hae strains isolated from BPF cases or their contacts [7].
Because Haemophilus influenzae type b (Hib) is the principal cause of suppurative arthritis in young children and its lipooligosaccharide (LOS) is thought to be the main virulence factor, Hib endotoxin was evaluated for its ability to induce synovial inflammation in rabbits [8].
The haem-haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzae [9].
A low-copy-number plasmid carrying rsmA(Pm) expressed from its native promoter caused suppression of swarming motility and expression of virulence factors in Proteus mirabilis. mRNA stability assays suggested that RsmA(Pm) inhibited virulence factor expression through promoting mRNA degradation [10].

Chemical compound and disease context of mviN

Haemophilus influenzae is an important cause of human disease, and its lipopolysaccharide (LPS) is known to be a major virulence factor [11].
Type b capsular polysaccharide as a virulence factor of Haemophilus influenzae [12].

Biological context of mviN

They are united by the virulence factor of their differing capsular polysaccharides, enabling them to evade phagocytosis [13].

Associations of mviN with chemical compounds

One surface antigen, the type b capsular polysaccharide, polyribosylribitol phosphate (PRP), is a primary virulence factor of the organism [14].

References

Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Bouchet, V., Hood, D.W., Li, J., Brisson, J.R., Randle, G.A., Martin, A., Li, Z., Goldstein, R., Schweda, E.K., Pelton, S.I., Richards, J.C., Moxon, E.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae. Müller, A., Severi, E., Mulligan, C., Watts, A.G., Kelly, D.J., Wilson, K.S., Wilkinson, A.J., Thomas, G.H. J. Biol. Chem. (2006) [Pubmed]
Rational use of Haemophilus influenzae type b vaccine. Campbell, H., Carter, H. Drugs (1993) [Pubmed]
Effect of pertussis toxin on susceptibility of infant rats to Haemophilus influenzae type b. Samore, M.H., Siber, G.R. J. Infect. Dis. (1992) [Pubmed]
Glycoprotein conjugate vaccines. Lindberg, A.A. Vaccine (1999) [Pubmed]
Structural studies of the cell envelope lipopolysaccharides from Haemophilus ducreyi strains ITM 2665 and ITM 4747. Schweda, E.K., Sundström, A.C., Eriksson, L.M., Jonasson, J.A., Lindberg, A.A. J. Biol. Chem. (1994) [Pubmed]
Brazilian purpuric fever caused by Haemophilus influenzae biogroup aegyptius strains lacking the 3031 plasmid. Tondella, M.L., Quinn, F.D., Perkins, B.A. J. Infect. Dis. (1995) [Pubmed]
Induction of suppurative arthritis in rabbits by Haemophilus endotoxin, tumor necrosis factor-alpha, and interleukin-1 beta. Sáez-Llorens, X., Jafari, H.S., Olsen, K.D., Nariuchi, H., Hansen, E.J., McCracken, G.H. J. Infect. Dis. (1991) [Pubmed]
The haem-haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzae. Morton, D.J., Seale, T.W., Madore, L.L., Vanwagoner, T.M., Whitby, P.W., Stull, T.L. Microbiology (Reading, Engl.) (2007) [Pubmed]
Role of RsmA in the regulation of swarming motility and virulence factor expression in Proteus mirabilis. Liaw, S.J., Lai, H.C., Ho, S.W., Luh, K.T., Wang, W.B. J. Med. Microbiol. (2003) [Pubmed]
Linking mass spectrometry and slab-polyacrylamide gel electrophoresis by passive elution of lipopolysaccharides from reverse-stained gels: analysis of gel-purified lipopolysaccharides from Haemophilus influenzae strain Rd. Gulin, S., Pupo, E., Schweda, E.K., Hardy, E. Anal. Chem. (2003) [Pubmed]
Type b capsular polysaccharide as a virulence factor of Haemophilus influenzae. Moxon, E.R., Kroll, J.S. Vaccine (1988) [Pubmed]
Capsulate bacteria and the lung. Buttery, J., Moxon, E.R. Br. Med. Bull. (2002) [Pubmed]
Haemophilus influenzae: surface antigens and aspects of virulence. Munson, R.S. Can. J. Vet. Res. (1990) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.