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Gene Review

GREB1  -  growth regulation by estrogen in breast...

Homo sapiens

Synonyms: Gene regulated in breast cancer 1 protein, KIAA0575, Protein GREB1
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Disease relevance of GREB1


High impact information on GREB1

  • GREB1 was also induced by beta-estradiol in the ER-positive endometrial cell line ECC-1 [1].
  • These three cDNAs of GREB1 shared extensive sequences through the open reading frame but had divergent 5' untranslated regions, indicating the possibility of multiple promoters regulated by beta-estradiol [1].
  • Treatment with cycloheximide indicated that ER directly controls GREB1 expression [1].
  • Estradiol-17beta (E2)-induced gene expression of pS2 and GREB1 was impaired by 50-75% after 24-72 h of E2 treatment in PR-transfected cells [4].
  • CONCLUSION: Our study suggests that GREB1 and HPCAL1 are candidate hypertension-susceptibility genes in the Japanese general population and supports previous studies that also identified hypertension-related loci in this narrow region [5].

Chemical compound and disease context of GREB1


Biological context of GREB1


Associations of GREB1 with chemical compounds

  • Quantitative real-time PCR assays confirmed that in all three cell lines, GREB 1 was induced by E2, but not by the antiestrogens tamoxifen (TAM) or ICI 182,780 [7].
  • Long-range histone acetylation, centered on the three ERE motifs and the GREB1 core promoters, was observed in response to estrogen but not to tamoxifen [8].

Physical interactions of GREB1


Regulatory relationships of GREB1


Other interactions of GREB1


  1. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Ghosh, M.G., Thompson, D.A., Weigel, R.J. Cancer Res. (2000) [Pubmed]
  2. GREB1 is a novel androgen-regulated gene required for prostate cancer growth. Rae, J.M., Johnson, M.D., Cordero, K.E., Scheys, J.O., Larios, J.M., Gottardis, M.M., Pienta, K.J., Lippman, M.E. Prostate (2006) [Pubmed]
  3. Changes in the subcellular distribution of glutathione during virus infection in Cucurbita pepo (L.). Zechmann, B., Zellnig, G., Müller, M. Plant biology (Stuttgart, Germany) (2005) [Pubmed]
  4. A novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells. Zheng, Z.Y., Bay, B.H., Aw, S.E., Lin, V.C. J. Biol. Chem. (2005) [Pubmed]
  5. Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population. Kamide, K., Kokubo, Y., Yang, J., Tanaka, C., Hanada, H., Takiuchi, S., Inamoto, N., Banno, M., Kawano, Y., Okayama, A., Tomoike, H., Miyata, T. J. Hypertens. (2005) [Pubmed]
  6. Ultrastructural localization of glutathione in Cucurbita pepo plants. Müller, M., Zechmann, B., Zellnig, G. Protoplasma (2004) [Pubmed]
  7. GREB 1 is a critical regulator of hormone dependent breast cancer growth. Rae, J.M., Johnson, M.D., Scheys, J.O., Cordero, K.E., Larios, J.M., Lippman, M.E. Breast Cancer Res. Treat. (2005) [Pubmed]
  8. Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells. Sun, J., Nawaz, Z., Slingerland, J.M. Mol. Endocrinol. (2007) [Pubmed]
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