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Gene Review

CLEC2B  -  C-type lectin domain family 2, member B

Homo sapiens

Synonyms: AICL, Activation-induced C-type lectin, C-type lectin domain family 2 member B, C-type lectin superfamily member 2, CLECSF2, ...
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Disease relevance of CLEC2B

  • In continuous ambulatory ECG recordings, AICL occurred hours before spontaneous initiation of sustained atrial and ventricular arrhythmias in different patient populations [1].

High impact information on CLEC2B


Anatomical context of CLEC2B


Associations of CLEC2B with chemical compounds

  • CHX treatment resulted also in an overexpression of AICL, LLT1, and CD161/NKR-P1A mRNAs [6].


  1. Detecting instabilities of cardiac rhythm. Shusterman, V., Aysin, B., Ermentrout, G.B., London, B., Schwartzman, D. Journal of electrocardiology. (2003) [Pubmed]
  2. Intracellular chloride activity in glial cells of the leech central nervous system. Ballanyi, K., Schlue, W.R. J. Physiol. (Lond.) (1990) [Pubmed]
  3. AICL: a new activation-induced antigen encoded by the human NK gene complex. Hamann, J., Montgomery, K.T., Lau, S., Kucherlapati, R., van Lier, R.A. Immunogenetics (1997) [Pubmed]
  4. Interleukin-12 induces gene expression in interleukin-2 stimulated human T lymphocytes. Li, B., Cao, D., Xu, H., Chang, J., Zhou, G., Tian, J., Li, D., Theze, J., Wu, C. Eur. Cytokine Netw. (2000) [Pubmed]
  5. Addition of cAMP to mucosal or serosal medium induces different actions on Necturus gallbladder. Díez de los Ríos, A., Acevedo, M., Sendra, F. Rev. Esp. Fisiol. (1985) [Pubmed]
  6. Differentially induced expression of C-type lectins in activated lymphocytes. Eichler, W., Ruschpler, P., Wobus, M., Drössler, K. J. Cell. Biochem. Suppl. (2001) [Pubmed]
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