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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Necturus

  • When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge [1].
  • Indeed, we identified the authentic thyroid hormone receptors of both alpha and beta types in two perennibranchiate species Necturus maculosus and Proteus anguinus [2].

High impact information on Necturus


Chemical compound and disease context of Necturus


Biological context of Necturus


Anatomical context of Necturus

  • Exogenous surface-active phospholipid protects Necturus gastric mucosa against luminal acid and barrier-breaking agents [18].
  • We have purified a protein from Necturus maculosus gallbladder cells that forms chloride channels in an artificial membrane [19].
  • Previous studies have shown that, immediately after the addition of galactose or alanine to the solution bathing the mucosal surface of Necturus small intestine, there is a rapid depolarization of the electrical potential difference across the mucosal membrane (psi mc) [20].
  • This study examined the role of Ca(2+) in regulatory volume decrease by Necturus erythrocytes [21].
  • The mechanisms of apparent streaming potentials elicited across Necturus gallbladder epithelium by addition or removal of sucrose from the apical bathing solution were studied by assessing the time courses of: (a) the change in transepithelial voltage (Vms) [22].

Associations of Necturus with chemical compounds


Gene context of Necturus

  • The percent identity between bird sequences and either mouse or mudpuppy was lower (79%); the mudpuppy AHR was 74% identical to the mouse AHR [27].
  • We localized gap junctions in the retinas of rat, goldfish, and mudpuppy by using antisera directed against proteins that make up the connexon channels in two tissues from which connexins have been isolated: liver (connexin 32; CX32) and heart (connexin 43; CX43) [28].
  • A specific androgen-binding protein (ABP) in Necturus testis and its zonal distribution [29].
  • In contrast, CFTR from the amphibians Necturus maculosus and Xenopus laevis (XCFTR) can be activated to similar degrees by stimulation of either PKA or PKC [30].
  • Characteristics of the galanin-induced depolarization of mudpuppy parasympathetic postganglionic neurons [31].

Analytical, diagnostic and therapeutic context of Necturus


  1. 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Slaughter, M.M., Miller, R.F. Science (1981) [Pubmed]
  2. Thyroid hormone receptors in perennibranchiate amphibians. Safi, R., Deprez, A., Laudet, V. Int. J. Dev. Biol. (1997) [Pubmed]
  3. Identification of a distinct synaptic glutamate receptor on horizontal cells in mudpuppy retina. Slaughter, M.M., Miller, R.F. Nature (1985) [Pubmed]
  4. Amacrine cells in Necturus retina: evidence for independent gamma-aminobutyric acid- and glycine-releasing neurons. Miller, R.F., Dacheux, R.F., Frumkes, T.E. Science (1977) [Pubmed]
  5. Luminal acid increases apical cell membrane resistance in isolated Necturus antral mucosa. Mustonen, H., Kivilaakso, E. Gastroenterology (1997) [Pubmed]
  6. Intracellular pH in isolated Necturus duodenal mucosa exposed to luminal acid. Paimela, H., Kiviluoto, T., Mustonen, H., Kivilaakso, E. Gastroenterology (1992) [Pubmed]
  7. Effects of aspirin on pathways of ion permeation in Necturus antrum: role of nutrient HCO3. Soybel, D.I., Davis, M.B., West, A.B. Gastroenterology (1992) [Pubmed]
  8. Synaptic organization and ionic basis of on and off channels in mudpuppy retina. II. Chloride-dependent ganglion cell mechanisms. Miller, R.F., Dacheux, R.F. J. Gen. Physiol. (1976) [Pubmed]
  9. The acetylcholine sensitivity of the surface membrane of multiply-innervated parasympathetic ganglion cells in the mudpuppy before and after partial denervation. Roper, S. J. Physiol. (Lond.) (1976) [Pubmed]
  10. Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina. II. Amacrine and ganglion cells. Miller, R.F., Frumkes, T.E., Slaughter, M., Dacheux, R.F. J. Neurophysiol. (1981) [Pubmed]
  11. Characterization of serine's inhibitory action on neurons in the mudpuppy retina. Slaughter, M.M., Miller, R.F. Neuroscience (1991) [Pubmed]
  12. Pituitary adenylate cyclase-activating polypeptide innervation of the mudpuppy cardiac ganglion. Schoenfeld, L.K., Souder, J.A., Hardwick, J.C. Brain Res. (2000) [Pubmed]
  13. Intracellular microelectrode studies of Necturus antral mucosa. Effect of aspirin on cell membrane potentials. Cheung, L.Y., De, L., Ashley, S.W. Gastroenterology (1985) [Pubmed]
  14. Effects of luminal hyperosmolality on cellular and paracellular ion transport pathways in necturus antrum. Soybel, D.I., Ashley, S.W., DeSchryver-Kecskemeti, K., Cheung, L.Y. Gastroenterology (1987) [Pubmed]
  15. Apical localization of K+ channels in taste cells provides the basis for sour taste transduction. Kinnamon, S.C., Dionne, V.E., Beam, K.G. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  16. Synaptic transmission at N-methyl-D-aspartate receptors in the proximal retina of the mudpuppy. Lukasiewicz, P.D., McReynolds, J.S. J. Physiol. (Lond.) (1985) [Pubmed]
  17. Cardiac actions of bovine parathyroid hormone fragment (1-34) in some lower vertebrates. Furspan, P.B., Sham, J.S., Shew, R.L., Peng, G., Pang, P.K. Gen. Comp. Endocrinol. (1984) [Pubmed]
  18. Exogenous surface-active phospholipid protects Necturus gastric mucosa against luminal acid and barrier-breaking agents. Kiviluoto, T., Paimela, H., Mustonen, H., Kivilaakso, E. Gastroenterology (1991) [Pubmed]
  19. Independently gated multiple substates of an epithelial chloride-channel protein. Finn, A.L., Dillard, M., Gaido, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  20. Cell swelling increases a barium-inhibitable potassium conductance in the basolateral membrane of Necturus small intestine. Lau, K.R., Hudson, R.L., Schultz, S.G. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  21. Cell swelling increases intracellular calcium in Necturus erythrocytes. Light, D.B., Attwood, A.J., Siegel, C., Baumann, N.L. J. Cell. Sci. (2003) [Pubmed]
  22. Pseudo-streaming potentials in Necturus gallbladder epithelium. II. The mechanism is a junctional diffusion potential. Reuss, L., Simon, B., Cotton, C.U. J. Gen. Physiol. (1992) [Pubmed]
  23. Na/H exchange in antral cells isolated from Necturus, rabbit, and guinea pig. Townsley, M.C., Paradiso, A.M., Machen, T.E. Gastroenterology (1988) [Pubmed]
  24. Effects of antiinflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa. Garner, A., Flemström, G., Heylings, J.R. Gastroenterology (1979) [Pubmed]
  25. Do N-methyl-D-aspartate receptors mediate synaptic responses in the mudpuppy retina? Coleman, P.A., Miller, R.F. J. Neurosci. (1988) [Pubmed]
  26. The role of excitatory amino acid transmitters in the mudpuppy retina: an analysis with kainic acid and N-methyl aspartate. Slaughter, M.M., Miller, R.F. J. Neurosci. (1983) [Pubmed]
  27. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Karchner, S.I., Kennedy, S.W., Trudeau, S., Hahn, M.E. Mar. Environ. Res. (2000) [Pubmed]
  28. Localization of gap junctions and tracer coupling in retinal Müller cells. Ball, A.K., McReynolds, J.S. J. Comp. Neurol. (1998) [Pubmed]
  29. A specific androgen-binding protein (ABP) in Necturus testis and its zonal distribution. Singh, S., Callard, G.V. J. Exp. Zool. (1989) [Pubmed]
  30. PKC-mediated stimulation of amphibian CFTR depends on a single phosphorylation consensus site. insertion of this site confers PKC sensitivity to human CFTR. Button, B., Reuss, L., Altenberg, G.A. J. Gen. Physiol. (2001) [Pubmed]
  31. Characteristics of the galanin-induced depolarization of mudpuppy parasympathetic postganglionic neurons. Konopka, L.M., Parsons, R.L. Neurosci. Lett. (1989) [Pubmed]
  32. Arachidonic-acid-activated membrane conductances in dissociated cardiac parasympathetic neurons from Necturus. Mulvaney, J.M., Parsons, R.L. J. Neurophysiol. (1995) [Pubmed]
  33. Localization of serotonin in taste buds: a comparative study in four vertebrates. Kim, D.J., Roper, S.D. J. Comp. Neurol. (1995) [Pubmed]
  34. Regulation of intracellular chloride activity during perfusion with hypertonic solutions in the Necturus proximal tubule. London, R., Cohen, B., Guggino, W.B., Giebisch, G. J. Membr. Biol. (1983) [Pubmed]
  35. Micropuncture study of the renal responses of the urodele amphibian Necturus maculosus to injections of arginine vasotocin and an anti-aldosterone compound. Garland, H.O., Henderson, I.W., Brown, J.A. J. Exp. Biol. (1975) [Pubmed]
  36. Electron microscopic immunocytochemistry of glutamate-containing nerve fibers in the taste bud of mudpuppy (Necturus maculosus). Lu, K.S., Roper, S.D. Microsc. Res. Tech. (1993) [Pubmed]
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