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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Cytology


High impact information on Cytology

  • PATIENTS AND METHODS: Fifty-nine adults with nonleukemic malignancies, performance status of 0 to 3, and positive CSF cytologies were assigned to receive intrathecal methotrexate (10 mg) or thiotepa (10 mg) twice weekly [5].
  • Sixty-one patients with histologically proven cancer and positive CSF cytologies were randomized to receive IT DepoCyt (31 patients) or IT methotrexate (30 patients) [6].
  • Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies [7].
  • Of the 49 AFM patients studied, nine (18%) had immunostained cells in the bone marrow, and only 1/49 (2%) had positive cytologies [8].
  • All patients with positive CSF cytologies had activated MMP2 [9].

Anatomical context of Cytology

  • Nasal neutrophilic influx, the surface expression of the B2 integrin CD11b on the nasal polymorphonuclear leukocytes (PMNs), rhinoscopic findings, respiratory symptoms, and nasal cytologies were evaluated in the 38 exposed children and in the 28 control children living in a nonpolluted Pacific coast port [10].

Associations of Cytology with chemical compounds

  • To obtain such data, the authors studied 23 cadmium workers with periodic analyses of blood/urine cadmium levels, hair cadmium content, urinary cytologies, creatinine clearance and urinary levels of lysozyme, beta-2-microglobulins, immunoglobulins, and aminoacids [11].
  • No significant difference was found between the stages of the nasal and temporal conjunctival impression cytologies in each eye, and there was no relationship between impression cytology stages and rose Bengal scores (p>0.05) [12].

Gene context of Cytology

  • Recent technical progress, including the use of GFAP (glial fibrillary acidic protein) directed antibody, may enhance the sensitivity of CSF cytologies [13].
  • Eighty-one individuals had urine cytologies, urinary carcinoembryonic antigen (CEA) determinations and urinary immunoglobulin levels performed in an effort to evaluate various screening tests for the diagnosis of bladder cancer [14].
  • A retrospective review of 200 cytologies originally diagnosed as SCC was undertaken in an attempt to characterize the cytomorphologic features of WDNE [15].


  1. Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas. Shibata, D., Almoguera, C., Forrester, K., Dunitz, J., Martin, S.E., Cosgrove, M.M., Perucho, M., Arnheim, N. Cancer Res. (1990) [Pubmed]
  2. Increased expression of the type 1 growth factor receptor family in the conjunctival epithelium of patients with keratoconjunctivitis sicca. Liu, Z., Carvajal, M., Carothers Carraway, C.A., Carraway, K.L., Pflugfelder, S.C. Am. J. Ophthalmol. (2000) [Pubmed]
  3. Cranial neuropathy heralding otherwise occult AIDS-related large cell lymphoma. Berger, J.R., Flaster, M., Schatz, N., Droller, D., Benedetto, P., Poblete, R., Post, M.J. Journal of clinical neuro-ophthalmology. (1993) [Pubmed]
  4. Peripheral neuroectodermal tumor presenting pleural effusion. Kurashima, K., Muramoto, S., Ohta, Y., Fujimura, M., Matsuda, T. Intern. Med. (1994) [Pubmed]
  5. Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. Grossman, S.A., Finkelstein, D.M., Ruckdeschel, J.C., Trump, D.L., Moynihan, T., Ettinger, D.S. J. Clin. Oncol. (1993) [Pubmed]
  6. A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Glantz, M.J., Jaeckle, K.A., Chamberlain, M.C., Phuphanich, S., Recht, L., Swinnen, L.J., Maria, B., LaFollette, S., Schumann, G.B., Cole, B.F., Howell, S.B. Clin. Cancer Res. (1999) [Pubmed]
  7. Spinal cord metastasis in small cell carcinoma of the lung. Holoye, P., Libnoch, J., Cox, J., Kun, L., Byhardt, R., Almagro, U., McClelland, S., Chintapali, K. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  8. Detection of tumor cells in the bone marrow of stage IV breast cancer patients receiving high-dose chemotherapy: the role of induction chemotherapy. Vredenburgh, J.J., Peters, W.P., Rosner, G., DeSombre, K., Johnston, W.W., Kamel, A., Wu, K., Bast, R.C. Bone Marrow Transplant. (1995) [Pubmed]
  9. Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis. Friedberg, M.H., Glantz, M.J., Klempner, M.S., Cole, B.F., Perides, G. Cancer (1998) [Pubmed]
  10. Nasal inflammatory responses in children exposed to a polluted urban atmosphere. Calderón-Garcidueñas, L., Rodriguez-Alcaraz, A., García, R., Ramírez, L., Barragan, G. Journal of toxicology and environmental health. (1995) [Pubmed]
  11. Cadmium nephropathy: monitoring for early evidence of renal dysfunction. Murray, T., Walker, B.R., Spratt, D.M., Chappelka, R. Arch. Environ. Health (1981) [Pubmed]
  12. Comparison of tear function tests and impression cytology with the ocular findings in acne rosacea. Yaylali, V., Ozyurt, C. European journal of ophthalmology. (2002) [Pubmed]
  13. Primary diffuse leptomeningeal gliomatosis (PDLG): a neoplastic cause of chronic meningitis. Dietrich, P.Y., Aapro, M.S., Rieder, A., Pizzolato, G.P. J. Neurooncol. (1993) [Pubmed]
  14. Screening tests for the detection of bladder cancer. Betkerur, V., Hliang, V., Baumgartner, G., Rao, R., Ablin, R.J., Guinan, P.D. Allergologia et immunopathologia. (1980) [Pubmed]
  15. The cytodiagnosis of well-differentiated neuroendocrine carcinoma. A distinct clinicopathologic entity. Jordan, A.G., Predmore, L., Sullivan, M.M., Memoli, V.A. Acta Cytol. (1987) [Pubmed]
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