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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Treatment Refusal

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Disease relevance of Treatment Refusal


High impact information on Treatment Refusal

  • Two patients have died (14, 11.5 months) without evidence of tumor: one of uncontrolled endocrine dysfunction due to patient noncompliance, the other of hyperosmolar coma [5].
  • However, the burden of prolonged subcutaneous portable pump infusions, high cost, and patient noncompliance have prompted the development of new methods of administration and new formulations of DFO as well as oral iron chelators [6].
  • Less-expensive alternatives (eg, generic products, medroxyprogesterone acetate injection) should be advocated to deter patient noncompliance because of cost issues [7].
  • In one patient noncompliance after 6 weeks of therapy was associated with a rapid return of her serum prolactin towards pretreatment levels [8].
  • There are several explanations for the medication concentrations observed in these patients: (1) patient noncompliance in ingestion of prescribed medication; (2) altered drug utilization; (3) a mild focus which is maintained under control with lower DPH levels than those necessary to control a more active focus; or (4) epilepsy in remission [9].

Chemical compound and disease context of Treatment Refusal


Gene context of Treatment Refusal

  • Factors associated with refractory renal disease in patients with systemic lupus erythematosus: the role of patient nonadherence [15].
  • The objectives of this study were to examine the rate of noncompliance and to investigate the factors that are associated with patient noncompliance with the prescribed EPO regimen [16].
  • The mean anthropometric values in all three groups were lower that in the whole CF population followed in "continental" France. This may reflect the poor compliance and even the refusal of treatment noted by the clinicians [17].

Analytical, diagnostic and therapeutic context of Treatment Refusal


  1. Subcutaneous or topical administration of 16,16 dimethyl prostaglandin E2 protects from radiation-induced alopecia in mice. Hanson, W.R., Pelka, A.E., Nelson, A.K., Malkinson, F.D. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  2. Defining the optimum treatment regimen for azithromycin in acute tonsillopharyngitis. Cohen, R. Pediatr. Infect. Dis. J. (2004) [Pubmed]
  3. In vitro and in vivo dapsone release from hydroxyapatite reservoirs. Lasserre, A., Berty, S., Bajpai, P.K. Biomedical sciences instrumentation. (1997) [Pubmed]
  4. Measuring patient compliance in the treatment of pulmonary tuberculosis in Cape Town--pitfalls in study design. Youngleson, S.M. S. Afr. Med. J. (1988) [Pubmed]
  5. Suprasellar germinoma: radiation therapy. Fields, J.N., Fulling, K.H., Thomas, P.R., Marks, J.E. Radiology. (1987) [Pubmed]
  6. Chelation therapy in beta-thalassemia: an optimistic update. Giardina, P.J., Grady, R.W. Semin. Hematol. (2001) [Pubmed]
  7. A comparative evaluation of oral contraceptive use and associated compliance issues in a rural population. Miller, L.G. Clinical therapeutics. (1995) [Pubmed]
  8. CV205-502, a new non-ergot dopamine agonist, reduces prolactinoma size in man. Barnett, P.S., Dawson, J.M., Butler, J., Coskeran, P.B., Maccabe, J.J., McGregor, A.M. Clin. Endocrinol. (Oxf) (1990) [Pubmed]
  9. The relation of anticonvulsant drug levels to complete seizure control. Feldman, R.G., Pippenger, C.E. Journal of clinical pharmacology. (1976) [Pubmed]
  10. Pharmacokinetic analysis of theophylline to assess noncompliance in therapy. Konishi, H., Nakatsuka, T., Yoshida, M., Tamaki, S., Minouchi, T., Yamaji, A., Kinoshita, M. The Annals of pharmacotherapy. (2002) [Pubmed]
  11. Pharmacokinetics of antiviral agents for the treatment of cytomegalovirus infection. Baillie, G.M. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. (2005) [Pubmed]
  12. The Supreme Court speaks on treatment refusal: the Cruzan case. Miller, R.D. Hospital law newsletter. (1990) [Pubmed]
  13. Excessive testosterone production in a patient with Nelson syndrome and bilateral testicular tumors. Shekarriz, M., Schneider, C., Sabanegh, E., Kempter, F., Waldherr, R. Urologia internationalis. (1996) [Pubmed]
  14. Patient noncompliance: a major cause of late graft failure in cyclosporine-treated renal transplants. Didlake, R.H., Dreyfus, K., Kerman, R.H., Van Buren, C.T., Kahan, B.D. Transplant. Proc. (1988) [Pubmed]
  15. Factors associated with refractory renal disease in patients with systemic lupus erythematosus: the role of patient nonadherence. Bruce, I.N., Gladman, D.D., Urowitz, M.B. Arthritis care and research : the official journal of the Arthritis Health Professions Association. (2000) [Pubmed]
  16. Factors influencing erythropoietin compliance in peritoneal dialysis patients. Wazny, L.D., Stojimirovic, B.B., Heidenheim, P., Blake, P.G. Am. J. Kidney Dis. (2002) [Pubmed]
  17. Cystic fibrosis at the Reunion Island (France): spectrum of mutations and genotype-phenotype for the Y122X mutation. Duguépéroux, I., Bellis, G., Lesure, J.F., Renouil, M., Flodrops, H., De Braekeleer, M. J. Cyst. Fibros. (2004) [Pubmed]
  18. Competent adult: refusal of treatment (renal dialysis) -- Re J.T. (Adult: Refusal of Treatment). Grubb, A. Medical law review. (1998) [Pubmed]
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