Disease relevance of Hidradenitis

• Four of the patients had a dermatologic triad of severe acne, hidradenitis suppurativa, and dissecting cellulitis of the scalp, the so-called follicular occlusion triad [1].
• Variation of melanocortin 5 receptor was examined in patients with acne (n = 21), hidradenitis supprativa (n = 4), and sebaceous gland lesions comprising sebaceous nevi, adenomas, and hyperplasia (n = 13) [2].
• We describe a 46-year-old man with Hodgkin's disease in whom neutrophilic eccrine hidradenitis developed after each of the first two treatments with lomustine [3].
• Glucose tolerance, lymphocyte populations, and HLA types were studied in 27 patients with untreated hidradenitis suppurativa; 18 of these patients had a negative history for acne vulgaris [4].
• The relationship between hidradenitis suppurativa (HS) and hyperandrogenism is largely based on the finding of an increased free androgen index due to a low sex hormone binding globulin (SHBG) [5].

High impact information on Hidradenitis

• Clinical assessment of 134 patients with hidradenitis suppurativa revealed clinical evidence supporting an androgen-based endocrine disorder underlying the condition [6].
• In response to a combined thyrotrophin releasing hormone and gonadotrophin releasing hormone test, the prolactin and TSH responses were significantly greater in the hidradenitis patients than the controls [7].
• Etanercept: effective in the management of hidradenitis suppurativa [8].
• Clindamycin and rifampicin combination therapy for hidradenitis suppurativa [9].
• CK expression in PS was similar to that in hidradenitis suppurativa, suggesting that sinus epithelium may be fragile, hyperproliferative and undifferentiated [10].

Chemical compound and disease context of Hidradenitis

• A review of the literature indicates that the results of treatment with isotretinoin for hidradenitis have been at best equivocal [11].
• BACKGROUND: Antibiotics are often used to treat hidradenitis, but only topical clindamycin has been shown to be effective in a randomized controlled trial [12].
• Surgical treatment of chronic hidradenitis suppurativa: CO2 laser stripping-secondary intention technique [13].
• Successful treatment of hidradenitis suppurativa with acitretin [14].
• We describe a patient in whom hidradenitis suppurativa developed while the patient was receiving lithium [15].

Anatomical context of Hidradenitis

• Androgen metabolism was investigated in normal human apocrine glands and in those isolated from age-matched patients with hidradenitis suppurativa [16].

Gene context of Hidradenitis

• A case of vulval SCC complicating hidradenitis suppurativa is presented [17].
• We describe a 63-year-old man with a severe HLA-B27 negative ankylosing spondylitis associated with hidradenitis suppurativa [18].
• Elevated parathyroid hormone-related protein and hypercalcemia in a patient with cutaneous squamous cell carcinoma complicating hidradenitis suppurativa [19].

References