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Gene Review

HCVgp1  -  polyprotein

Hepatitis C virus

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Disease relevance of HCVgp1


High impact information on HCVgp1

  • During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3 [5].
  • A serine protease located within the HCV NS3 protein processes the viral polyprotein at four specific sites and is considered essential for replication [6].
  • To determine if immunologically driven sequence variation occurs with HCV persistence, we coordinately analyzed sequence evolution and CD8+ T cell responses to epitopes covering the entire HCV polyprotein in subjects who were followed prospectively from before infection to beyond the first year [7].
  • METHODS: Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structural proteins (S-N transgene) were compared with nontransgenic littermates for altered liver morphology and function [8].
  • During biosynthesis of the polyprotein, an internal signal sequence between the core protein and the envelope protein E1 targets the nascent polypeptide to the endoplasmic reticulum (ER) membrane for translocation of E1 into the ER [4].

Chemical compound and disease context of HCVgp1


Biological context of HCVgp1


Anatomical context of HCVgp1


Associations of HCVgp1 with chemical compounds


Analytical, diagnostic and therapeutic context of HCVgp1


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