Gene Review:
HCVgp1 - polyprotein
Hepatitis C virus
- The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins. Lin, C., Wu, J.W., Hsiao, K., Su, M.S. J. Virol. (1997)
- Interaction of hepatitis C virus NS5A with La protein revealed by T7 phage display. Houshmand, H., Bergqvist, A. Biochem. Biophys. Res. Commun. (2003)
- Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Furutani, T., Hino, K., Okuda, M., Gondo, T., Nishina, S., Kitase, A., Korenaga, M., Xiao, S.Y., Weinman, S.A., Lemon, S.M., Sakaida, I., Okita, K. Gastroenterology (2006)
- Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. McLauchlan, J., Lemberg, M.K., Hope, G., Martoglio, B. EMBO J. (2002)
- The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Love, R.A., Parge, H.E., Wickersham, J.A., Hostomsky, Z., Habuka, N., Moomaw, E.W., Adachi, T., Hostomska, Z. Cell (1996)
- Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Kim, J.L., Morgenstern, K.A., Lin, C., Fox, T., Dwyer, M.D., Landro, J.A., Chambers, S.P., Markland, W., Lepre, C.A., O'Malley, E.T., Harbeson, S.L., Rice, C.M., Murcko, M.A., Caron, P.R., Thomson, J.A. Cell (1996)
- Cellular immune selection with hepatitis C virus persistence in humans. Cox, A.L., Mosbruger, T., Mao, Q., Liu, Z., Wang, X.H., Yang, H.C., Sidney, J., Sette, A., Pardoll, D., Thomas, D.L., Ray, S.C. J. Exp. Med. (2005)
- Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Lerat, H., Honda, M., Beard, M.R., Loesch, K., Sun, J., Yang, Y., Okuda, M., Gosert, R., Xiao, S.Y., Weinman, S.A., Lemon, S.M. Gastroenterology (2002)
- The hepatitis C virus NS3 proteinase: structure and function of a zinc-containing serine proteinase. De Francesco, R., Pessi, A., Steinkühler, C. Antivir. Ther. (Lond.) (1998)
- Protein kinase C recognizes the protein kinase A-binding motif of nonstructural protein 3 of hepatitis C virus. Borowski, P., zur Wiesch, J.S., Resch, K., Feucht, H., Laufs, R., Schmitz, H. J. Biol. Chem. (1999)
- Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. Egger, D., Wölk, B., Gosert, R., Bianchi, L., Blum, H.E., Moradpour, D., Bienz, K. J. Virol. (2002)
- Substrate requirements of hepatitis C virus serine proteinase for intermolecular polypeptide cleavage in Escherichia coli. Komoda, Y., Hijikata, M., Sato, S., Asabe, S., Kimura, K., Shimotohno, K. J. Virol. (1994)
- Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein. Ede, N.J., Eagle, S.N., Wickham, G., Bray, A.M., Warne, B., Shoemaker, K., Rosenberg, S. J. Pept. Sci. (2000)
- Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. Cheng, P.L., Chang, M.H., Chao, C.H., Lee, Y.H. Oncogene (2004)
- A genomic approach of the hepatitis C virus generates a protein interaction map. Flajolet, M., Rotondo, G., Daviet, L., Bergametti, F., Inchauspé, G., Tiollais, P., Transy, C., Legrain, P. Gene (2000)
- Hepatitis C virus (HCV) NS5A protein downregulates HCV IRES-dependent translation. Kalliampakou, K.I., Kalamvoki, M., Mavromara, P. J. Gen. Virol. (2005)
- Synthesis of a novel hepatitis C virus protein by ribosomal frameshift. Xu, Z., Choi, J., Yen, T.S., Lu, W., Strohecker, A., Govindarajan, S., Chien, D., Selby, M.J., Ou, J. EMBO J. (2001)
- Genetic organization and diversity of the hepatitis C virus. Choo, Q.L., Richman, K.H., Han, J.H., Berger, K., Lee, C., Dong, C., Gallegos, C., Coit, D., Medina-Selby, R., Barr, P.J. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Triple decoding of hepatitis C virus RNA by programmed translational frameshifting. Choi, J., Xu, Z., Ou, J.H. Mol. Cell. Biol. (2003)
- Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein. Disson, O., Haouzi, D., Desagher, S., Loesch, K., Hahne, M., Kremer, E.J., Jacquet, C., Lemon, S.M., Hibner, U., Lerat, H. Gastroenterology (2004)
- Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Hijikata, M., Mizushima, H., Tanji, Y., Komoda, Y., Hirowatari, Y., Akagi, T., Kato, N., Kimura, K., Shimotohno, K. Proc. Natl. Acad. Sci. U.S.A. (1993)
- The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling. Macdonald, A., Crowder, K., Street, A., McCormick, C., Saksela, K., Harris, M. J. Biol. Chem. (2003)
- Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. Tanji, Y., Hijikata, M., Satoh, S., Kaneko, T., Shimotohno, K. J. Virol. (1995)
- Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A. Gallinari, P., Paolini, C., Brennan, D., Nardi, C., Steinkühler, C., De Francesco, R. Biochemistry (1999)
- Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1. Duong, F.H., Christen, V., Berke, J.M., Penna, S.H., Moradpour, D., Heim, M.H. J. Virol. (2005)
- Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment. Penin, F., Combet, C., Germanidis, G., Frainais, P.O., Deléage, G., Pawlotsky, J.M. J. Virol. (2001)
- Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses. Vajdy, M., Selby, M., Medina-Selby, A., Coit, D., Hall, J., Tandeske, L., Chien, D., Hu, C., Rosa, D., Singh, M., Kazzaz, J., Nguyen, S., Coates, S., Ng, P., Abrignani, S., Lin, Y.L., Houghton, M., O'Hagan, D.T. J. Gen. Virol. (2006)
- Hepatitis C virus glycoprotein E2 binding to CD81: the role of E1E2 cleavage and protein glycosylation in bioactivity. Chan-Fook, C., Jiang, W.R., Clarke, B.E., Zitzmann, N., Maidens, C., McKeating, J.A., Jones, I.M. Virology (2000)
- Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Yanagi, M., Purcell, R.H., Emerson, S.U., Bukh, J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase. Schmidt-Mende, J., Bieck, E., Hugle, T., Penin, F., Rice, C.M., Blum, H.E., Moradpour, D. J. Biol. Chem. (2001)
- Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. Schulze zur Wiesch, J., Lauer, G.M., Day, C.L., Kim, A.Y., Ouchi, K., Duncan, J.E., Wurcel, A.G., Timm, J., Jones, A.M., Mothe, B., Allen, T.M., McGovern, B., Lewis-Ximenez, L., Sidney, J., Sette, A., Chung, R.T., Walker, B.D. J. Immunol. (2005)
- Regulated processing of hepatitis C virus core protein is linked to subcellular localization. Liu, Q., Tackney, C., Bhat, R.A., Prince, A.M., Zhang, P. J. Virol. (1997)
- Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients. Rehermann, B., Chang, K.M., McHutchinson, J., Kokka, R., Houghton, M., Rice, C.M., Chisari, F.V. J. Virol. (1996)