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MeSH Review

Sertoli Cell Tumor

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Disease relevance of Sertoli Cell Tumor


High impact information on Sertoli Cell Tumor

  • Its ultrastructural characteristics and the expression of genes that are transcribed in vivo in male germ cells (c-kit, LDH-X, and Hox a-4) suggest the progression of an initial, apparently pure Sertoli cell tumor into a mixed proliferation [4].
  • In conclusion, although the same stromal tumor, large-cell calcifying Sertoli cell tumor, affects the testes in CNC and PJS, we did not find such tumors in a small population of CNC patients that was studied prospectively or a larger group of CNC patients that was studied retrospectively [5].
  • This study concerns the immunohistochemical localization of S-100 alpha, S-100 beta, and whole brain S-100 (wbS-100) in testicular large-cell calcifying Sertoli cell tumor (LCCSCT) [6].
  • Sertoli cell tumor in androgen insensitivity syndrome--a case report [7].
  • On the other hand, medium collected from cultures of cells isolated from a Sertoli cell tumor was able to stimulate testosterone secretion in subcultures of control testicular cells in a way similar to that of hCG [8].

Chemical compound and disease context of Sertoli Cell Tumor


Anatomical context of Sertoli Cell Tumor


Gene context of Sertoli Cell Tumor


  1. Resistant hypertension associated with a renin-producing ovarian Sertoli cell tumor. Korzets, A., Nouriel, H., Steiner, Z., Griffel, B., Kraus, L., Freund, U., Klajman, A. Am. J. Clin. Pathol. (1986) [Pubmed]
  2. Bone marrow hypoplasia in eight dogs with Sertoli cell tumor. Sherding, R.G., Wilson, G.P., Kociba, G.J. J. Am. Vet. Med. Assoc. (1981) [Pubmed]
  3. Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. Sato, K., Ueda, Y., Sakurai, A., Ishikawa, Y., Okamoto, S.Y., Ikawa, H., Katsuda, S. Pathol. Int. (2005) [Pubmed]
  4. Experimental Sertoli cell tumors in the mouse and their progression into a mixed germ cell-sex cord proliferation. Paquis-Flucklinger, V., Rassoulzadegan, M., Michiels, J.F. Am. J. Pathol. (1994) [Pubmed]
  5. Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy. Stratakis, C.A., Papageorgiou, T., Premkumar, A., Pack, S., Kirschner, L.S., Taymans, S.E., Zhuang, Z., Oelkers, W.H., Carney, J.A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  6. Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis. Tanaka, Y., Carney, J.A., Ijiri, R., Kato, K., Miyake, T., Nakatani, Y., Misugi, K. Hum. Pathol. (2002) [Pubmed]
  7. Sertoli cell tumor in androgen insensitivity syndrome--a case report. Wysocka, B., Serkies, K., Debniak, J., Jassem, J., Limon, J. Gynecol. Oncol. (1999) [Pubmed]
  8. Human prepubertal testicular cells in culture: steroidogenic capacity, paracrine and hormone control. Rivarola, M.A., Belgorosky, A., Berensztein, E., de Dávila, M.T. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  9. Estrogen-producing Sertoli cell tumor of the ovary--a case report. Shalev, E., Zuckerman, H., Risescu, I. Gynecol. Oncol. (1984) [Pubmed]
  10. Progesterone secreting Sertoli cell tumor of the ovary. Tracy, S.L., Askin, F.B., Reddick, R.L., Jackson, B., Kurman, R.J. Gynecol. Oncol. (1985) [Pubmed]
  11. Measurement of telomerase activity in dog tumors. Yazawa, M., Okuda, M., Setoguchi, A., Nishimura, R., Sasaki, N., Hasegawa, A., Watari, T., Tsujimoto, H. J. Vet. Med. Sci. (1999) [Pubmed]
  12. A(870)E mutation of the androgen receptor gene in a patient with complete androgen insensitivity syndrome and Sertoli cell tumor. Knoke, I., Jakubiczka, S., Ottersen, T., Göppinger, A., Wieacker, P. Cancer Genet. Cytogenet. (1997) [Pubmed]
  13. Pathologic quiz case: incidental bilateral testicular nodules in an African American man. Large cell calcifying Sertoli cell tumor. Aydin, H., Omeroglu, G., Omeroglu, A. Arch. Pathol. Lab. Med. (2004) [Pubmed]
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