Disease relevance of Sertoli Cell Tumor

• Resistant hypertension associated with a renin-producing ovarian Sertoli cell tumor [1].
• Eight male dogs with Sertoli cell tumor had pancytopenia and bone marrow hypoplasia attributed to endogenous estrogen myelotoxicosis [2].
• The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor [3].

High impact information on Sertoli Cell Tumor

• Its ultrastructural characteristics and the expression of genes that are transcribed in vivo in male germ cells (c-kit, LDH-X, and Hox a-4) suggest the progression of an initial, apparently pure Sertoli cell tumor into a mixed proliferation [4].
• In conclusion, although the same stromal tumor, large-cell calcifying Sertoli cell tumor, affects the testes in CNC and PJS, we did not find such tumors in a small population of CNC patients that was studied prospectively or a larger group of CNC patients that was studied retrospectively [5].
• This study concerns the immunohistochemical localization of S-100 alpha, S-100 beta, and whole brain S-100 (wbS-100) in testicular large-cell calcifying Sertoli cell tumor (LCCSCT) [6].
• Sertoli cell tumor in androgen insensitivity syndrome--a case report [7].
• On the other hand, medium collected from cultures of cells isolated from a Sertoli cell tumor was able to stimulate testosterone secretion in subcultures of control testicular cells in a way similar to that of hCG [8].

Chemical compound and disease context of Sertoli Cell Tumor

• Estrogen-secreting Sertoli cell tumor of the ovary is rare [9].
• Progesterone secreting Sertoli cell tumor of the ovary [10].

Anatomical context of Sertoli Cell Tumor

• We measured telomerase activity in tumor samples from 45 dogs; 21 mammary gland tumors, 16 tumors developed in the skin and oral cavity, 7 vascular tumors and 1 Sertoli cell tumor [11].

Gene context of Sertoli Cell Tumor

• A(870)E mutation of the androgen receptor gene in a patient with complete androgen insensitivity syndrome and Sertoli cell tumor [12].
• Pathologic quiz case: incidental bilateral testicular nodules in an African American man. Large cell calcifying Sertoli cell tumor [13].

References