Disease relevance of Vasa Nervorum

• The aim was to investigate the effects of 2 months of streptozotocin-induced diabetes mellitus in rats on the responses of sciatic vasa nervorum to vasoactive drugs [1].

High impact information on Vasa Nervorum

• Functional improvements may relate to enhanced vasa nervorum perfusion, because endoneurial capillary density increased by 22% with Efamol, angiogenesis perhaps resulting from eicosanoid production from arachidonic acid [2].
• 5. These findings indicate that the capsaicin hyperaemia of vasa nervorum is locally mediated, is independent of central afferent connections and is sensitive to a variety of interventions [3].
• The presence of norepinephrine (NE)-containing terminals on vasa nervorum suggests that adrenergic regulation may be important [4].
• Diabetes also elevates the endothelial angiotensin system, increasing vasa nervorum vasoconstriction [5].
• Vasa nervorum adrenergic responsiveness to tyramine (presynaptic) and phenylephrine (postsynaptic) was investigated [6].

Biological context of Vasa Nervorum

• The decrease, which was nearly abolished by an i.v. alpha-adrenergic blocker, phentolamine (10 mg/kg), resulted from vasoconstriction in the vasa nervorum, mainly via activation of alpha-adrenergic receptors [7].

Anatomical context of Vasa Nervorum

• The control nerves showed beta 1 integrin-stained cells in the perineurium and vasa nervorum but the endoneurium was negative [8].
• Adrenergic nerves were studied in nervi nervorum and perivascular nerve plexus of vasa nervorum in whole-mount nerve sheath preparations of optic, sciatic and vagus nerves and in the paravertebral sympathetic chain in normal and streptozotocin-treated diabetic rats [9].
• The nerve microcirculation, the "vasa nervorum" was examined using casting materials, methyl methacrylate and silicone rubber, which were in turn examined by light microscopy and scanning electron microscopy [10].

Associations of Vasa Nervorum with chemical compounds

• Differential vulnerability of neuropeptides in nerves of the vasa nervorum to streptozotocin-induced diabetes [11].
• The impact of aging on vasa nervorum, nerve blood flow and vasopressin responsiveness [12].
• Thus, diabetes causes a deficit in nitric oxide mediated endothelium-dependent relaxation of vasa nervorum, resulting in increased vasoconstrictor sensitivity which is likely to impair perfusion and contribute to the pathogenesis of neuropathy [1].

Gene context of Vasa Nervorum

• Local application of specific receptor antagonists of SP or CGRP results in constriction of vasa nervorum [13].
• The findings that acetylcholinesterase-positive nerve fibres were unalterated by chemical sympathectomy and were revealed by short incubation times are indicative of a true cholinergic, and probably parasympathetic, innervation of the vasa nervorum [14].

References