Disease relevance of Sympathectomy, Chemical

• The development of two-kidney, two clip Goldblatt hypertension (2K2C) in the rat seems to be unaffected by chemical sympathectomy with 6-hydroxydopamine (6-HODA) and adrenal demedullation [1].
• We conclude that chemical sympathectomy normalizes basal corticosterone levels but has no effect on ACTH-stimulated corticosterone levels in 7-d-old rats exposed to hypoxia from birth [2].
• Prevention of exercise-induced cardiac hypertrophy in rats by chemical sympathectomy (guanethidine treatment) [3].
• Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion [4].
• Chemical sympathectomy of adult mice with 6-hydroxydopamine (6-OHDA) either prior to or following epicutaneous sensitization with the trinitrophenyl (TNP) hapten decreased the delayed hypersensitivity (DH) response to ear challenge [5].

High impact information on Sympathectomy, Chemical

• After chemical sympathectomy with reserpine or 6-OH dopamine, there was a 100% increase in receptor specific binding [6].
• Prior chemical sympathectomy and adrenergic receptor blockade almost abolished the ANF response to scorpion venom but hardly affected the ANF response to veratridine [7].
• We have previously shown that chemical sympathectomy with 6-hydroxydopamine increases cardiac PNMT levels [8].
• Following chemical sympathectomy with 6-hydroxydopamine, ouabain contractions were 11% of control, whereas the contractions due to exogenous norepinephrine were exaggerated [9].
• Antiadrenergic interventions, including chemical sympathectomy in vivo with 6-hydroxydopamine and alpha- and beta-adrenergic blockade with phentolamine and L-propranolol (both 10(-6 M), did not significantly attenuate the contractions [10].

Chemical compound and disease context of Sympathectomy, Chemical

• Pretreatment with 6-hydroxydopamine (chemical sympathectomy) or pentolinium tartrate (ganglion blockade) abolished the stimulatory actions of angiotensin II but left the responses to noradrenaline unimpaired [11].
• Lumbar chemical sympathectomy using 5% phenol in glycerin alleviated intermittent claudication and improved cutaneous blood flow [12].
• Attenuation by chronic imipramine treatment of [3H]clonidine binding to cortical membranes and of clonidine-induced hypothermia: the influence of central chemosympathectomy [13].
• We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response [14].
• Neonatal chemical sympathectomy attenuates fructose-induced hypertriglyceridemia and hypertension in rats [15].

Biological context of Sympathectomy, Chemical

• Further, neonatal chemical sympathectomy using guanethidine abolished the exaggerated response in blood pressure and in urinary excretion of NE and VMA in WKYpch1 [16].
• Treatment with tyramine did not affect the amplitude of the EPSP in tissue that had undergone prior chemical sympathectomy with 6-hydroxydopamine [17].
• After neonatal chemical sympathectomy, changes in weight and food intake were compared in groups of sympathectomized (SYM) and control (CON) adult animals during ICV infusion of leptin [4].
• In additional studies, chemical sympathectomy with 6-hydroxydopamine, combined with adrenal medullectomy did not prevent the effect of PCA on the activity of plasma renin even though the renal content of norepinephrine was reduced to undetectable levels [18].
• Decreasing peripheral vascular resistance by chemical sympathectomy with thoracic epidural anesthesia lowers the systemic arterial pressure and improves the DPTI/SPTI ratio [19].

Anatomical context of Sympathectomy, Chemical

• METHODS: Tissue and bone marrow norepinephrine content was ablated by chemical sympathectomy with 6-hydroxydopamine treatment [20].
• To assess the importance of adrenergic nerves in this phenomenon, high doses (600 microgram/ml) of 6-hydroxydopamine (6-OHDA) were used to produce in vitro chemical sympathectomy in bovine middle cerebral artery [21].
• Neural control of the internal anal sphincter of cats after chemical sympathectomy with 6-hydroxydopamine [22].
• Experiments were performed under control conditions, chemical sympathectomy by 6-hydroxy-dopamine, ganglionic blockade by hexamethonium, and surgical denervation of sino-aortic baroreceptors [23].
• Direct calcium-stimulated release of glucagon from the isolation perfused rat pancreas and the effect of chemical sympathectomy [24].

Associations of Sympathectomy, Chemical with chemical compounds

• This effect of intrahypothalamic injection of tyramine was abolished by bilateral cervical sympathectomy but not by chemical sympathectomy of the upper brainstem [25].
• To evaluate the importance of renal nerves in this response, an additional group of animals underwent chemical sympathectomy with guanethidine [26].
• This study provides further evidence epinephrine administration can result in chemical sympathectomy as has been described following 6-hydroxydopamine [27].
• The purpose of the present study was to determine whether this increase in corticosterone could be attenuated by chemical sympathectomy induced with guanethidine treatment [2].
• The quinacrine fluorescent neural structures are unaffected by chemical sympathectomy with 6-hydroxydopamine [28].

Gene context of Sympathectomy, Chemical

• 3. Chemical sympathectomy abolished TH- and NPY-IR nerve structures in cavernous smooth muscle bundles [29].
• Chemical sympathectomy did not affect Ucn immunoreactivity of parietal cells [30].
• Sequential staining for dopamine-beta-hydroxylase and NPY together with results of chemical sympathectomy with 6-hydroxydopamine suggested that NPY was stored in the noradrenergic sympathetic nerves [31].
• The systemic impact of a neural distribution is suggested by a 60% reduction of blood tPA activity after chemical sympathectomy [32].
• We inquired whether a chemical sympathectomy will alter the release of t-PA into the blood, and the intrinsic release of stored t-PA from isolated whole vessel explants [33].

Analytical, diagnostic and therapeutic context of Sympathectomy, Chemical

• METHODS: Beta-adrenergic and MR receptor concentrations were studied in beagle dogs nine days after chemical sympathectomy (using the neurotoxin 6-hydroxydopamine) or 3-7 wk and 23-28 wk after surgical intrapericardial denervation [34].
• However, in intact rats and rats that had undergone both vagotomy and chemical sympathectomy, this suppressive effect of leptin on insulin secretion was not detected [35].
• METHODS: PET studies of myocardial sympathetic innervation, myocardial perfusion and oxygen utilization using [11C]hydroxyephedrine (HED), [13N]ammonia and 1-[11C]acetate, respectively, were performed before and approximately 2 and 8 wk after surgical left thoracotomy and regional chemical sympathetic denervation (n = 5) [36].
• In this study, bilateral adrenalectomy and chemical sympathectomy by 6-hydroxydopamine (6-OH-DA) were used to examine the contributions of the adrenal medullae and sympathetic nerve terminals to the pressor and tachycardic responses to DPI in pentobarbital-anesthetized rats [37].
• The effect of 'chemical sympathectomy', produced by daily intraperitoneal injections of guanethidine sulphate for six weeks, was studied in sedentary rats and in rats chronically exercised by swimming [3].

References