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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Biological Sciences

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Disease relevance of Biological Sciences


High impact information on Biological Sciences

  • Japan. Summit seeks boost for life sciences [2].
  • Claude Bernard, the son of a Beaujolais winegrower, moved to Paris to pursue his literary ambitions and went on to become one of the fathers of modern life sciences [3].
  • "The Glass Ceiling for Women in the Life Sciences Meeting", organized by the European Molecular Biology Organization (EMBO), was held on 22-23 June 2001 in Heidelberg, Germany [4].
  • On November 29-30, 1995, the National Academy of Sciences and the Institute of Medicine brought together experts in schizophrenia and specialists in other areas of the biological sciences in a workshop aimed at promoting the application of the latest biological information to this clinical problem [5].
  • In the last decade interactions of fluorine substituents in a variety of organic compounds have gained interest in life science and solid state materials [6].

Biological context of Biological Sciences


Anatomical context of Biological Sciences

  • Sarmesin, [Sar1, Tyr(Me)4]angiotensinII], has been reported to be a competitive angiotensin II (AII) receptor antagonist in rat smooth muscle preparations (Scanlon et al., (1984), Life Science 34, 317-321) [10].

Associations of Biological Sciences with chemical compounds

  • The present study was designed to determine whether this abnormality could be counteracted either by increasing the intraislet insulin level or by normalizing the diabetic state by a glucose-controlled insulin infusion system (GCIIS: Biostator, Life Science Instruments, Elkhart, Indiana) [11].
  • Chicken avidin and bacterial streptavidin are proteins used in a wide variety of applications in the life sciences due to their strong affinity for biotin [12].
  • Polyacrylamide gel electrophoresis has become the most widely used separation method in biological science [13].
  • Protonated and deprotonated biological molecules in the gas phase play an important role in life sciences research [14].
  • Three different microcarriers, collagen-coated polystyrene (Kontes Life Sciences Products, Vineland, N.J.), Gelibead (Hazelton Research Products, Inc., Lenexa, Kans.), and Cytodex 3 (Pharmacia Fine Chemicals, Piscataway, N.J.), were used to compare the propagation of these anchorage-dependent cells [15].

Gene context of Biological Sciences

  • Of these gene products, avidin is the best characterized and is known for its extremely high affinity for D-biotin, a property that is utilized in numerous modern life science applications [16].
  • The variant was isolated from manufacturing process of LG Life Sciences' hGH product [17].
  • We argue that the search for traces of life on Mars represents a major thought-provoking challenge for the life sciences that should be taken up by the biological community [18].
  • The ability to conjugate reporter groups to ROMP polymers using this strategy has broad applications in the material and biological sciences [19].
  • All related Technical, Corporate, and Flight Test Reports in the KRUG Life Sciences corporate library were also reviewed [20].

Analytical, diagnostic and therapeutic context of Biological Sciences

  • METHODS: We used a time-resolved fluoroimmunoassay method for TSH and T4 with the AutoDELPHIA instrument (Perkin-Elmer Life Sciences, Turku, Finland) [21].
  • This improved p24 antigen test, for which all reagents are available from Perkin Elmer Life Sciences, was evaluated in clinical studies in comparison with the most sensitive PCR methods available at a given time [22].


  1. Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond. Austin, M.A. Am. J. Epidemiol. (1989) [Pubmed]
  2. Japan. Summit seeks boost for life sciences. Normile, D. Science (2001) [Pubmed]
  3. Claude Bernard: primer of the second biomedical revolution. Conti, F. Nat. Rev. Mol. Cell Biol. (2001) [Pubmed]
  4. Breaking glass? Wilson, E.K. Trends Biochem. Sci. (2001) [Pubmed]
  5. Workshop on schizophrenia. Barondes, S.H., Alberts, B.M., Andreasen, N.C., Bargmann, C., Benes, F., Goldman-Rakic, P., Gottesman, I., Heinemann, S.F., Jones, E.G., Kirschner, M., Lewis, D., Raff, M., Roses, A., Rubenstein, J., Snyder, S., Watson, S.J., Weinberger, D.R., Yolken, R.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Fluorine in crystal engineering--"the little atom that could". Reichenbächer, K., Süss, H.I., Hulliger, J. Chemical Society reviews. (2005) [Pubmed]
  7. Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays. Baker, V.A., Harries, H.M., Waring, J.F., Duggan, C.M., Ni, H.A., Jolly, R.A., Yoon, L.W., De Souza, A.T., Schmid, J.E., Brown, R.H., Ulrich, R.G., Rockett, J.C. Environ. Health Perspect. (2004) [Pubmed]
  8. ExPASy: The proteomics server for in-depth protein knowledge and analysis. Gasteiger, E., Gattiker, A., Hoogland, C., Ivanyi, I., Appel, R.D., Bairoch, A. Nucleic Acids Res. (2003) [Pubmed]
  9. Hematological measurements in rats flown on Spacelab shuttle, SL-3. Lange, R.D., Andrews, R.B., Gibson, L.A., Congdon, C.C., Wright, P., Dunn, C.D., Jones, J.B. Am. J. Physiol. (1987) [Pubmed]
  10. Sarmesin is a partial agonist of angiotensin-II receptors in rabbit, but not in rat, aortic rings. Criscione, L., Thomann, H., Whitebread, S., de Gasparo, M., Kamber, B. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  11. Reversal of D- and A-cell insensitivity to glucose in alloxan-diabetic dogs by treatment with the artificial beta cell (Biostator). Hermansen, K., Schmitz, O., Orskov, H. Diabetes (1985) [Pubmed]
  12. Characterization of poultry egg-white avidins and their potential as a tool in pretargeting cancer treatment. Hytönen, V.P., Laitinen, O.H., Grapputo, A., Kettunen, A., Savolainen, J., Kalkkinen, N., Marttila, A.T., Nordlund, H.R., Nyholm, T.K., Paganelli, G., Kulomaa, M.S. Biochem. J. (2003) [Pubmed]
  13. Localization of separated protein bands in unstained electrophoresed polyacrylamide gradient slab gel. Arora, D.J. Electrophoresis (1992) [Pubmed]
  14. Increasing the negative charge of a macroanion in the gas phase via sequential charge inversion reactions. He, M., McLuckey, S.A. Anal. Chem. (2004) [Pubmed]
  15. Growth of Vero E-6 cells on microcarriers in a cell bioreactor. White, L.A., Ades, E.W. J. Clin. Microbiol. (1990) [Pubmed]
  16. Avidin related protein 2 shows unique structural and functional features among the avidin protein family. Hytönen, V.P., Määttä, J.A., Kidron, H., Halling, K.K., Hörhä, J., Kulomaa, T., Nyholm, T.K., Johnson, M.S., Salminen, T.A., Kulomaa, M.S., Airenne, T.T. BMC Biotechnol. (2005) [Pubmed]
  17. Characterization of N alpha-acetyl methionyl human growth hormone formed during expression in Saccharomyces cerevisiae with liquid chromatography and mass spectrometry. Jung, C., Lee, Y.P., Jeong, Y.R., Kim, J.Y., Kim, Y.H., Kim, H.S. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2005) [Pubmed]
  18. Why biologists should support the exploration of Mars. Maurel, M.C., Zaccai, G. Bioessays (2001) [Pubmed]
  19. Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions. Gordon, E.J., Gestwicki, J.E., Strong, L.E., Kiessling, L.L. Chem. Biol. (2000) [Pubmed]
  20. Blunt trauma and operative care in microgravity: a review of microgravity physiology and surgical investigations with implications for critical care and operative treatment in space. Kirkpatrick, A.W., Campbell, M.R., Novinkov, O.L., Goncharov, I.B., Kovachevich, I.V. J. Am. Coll. Surg. (1997) [Pubmed]
  21. Age-dependent cutoff values in screening newborns for hypothyroidism. Lott, J.A., Sardovia-Iyer, M., Speakman, K.S., Lee, K.K. Clin. Biochem. (2004) [Pubmed]
  22. Measurement of HIV-1 p24 antigen by signal-amplification-boosted ELISA of heat-denatured plasma is a simple and inexpensive alternative to tests for viral RNA. Schüpbach, J. AIDS reviews. (2002) [Pubmed]
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