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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Internet


High impact information on Internet

  • Over 200 genes are now known to be regulated by IFN-gamma and they are listed in a World Wide Web document that accompanies this review [4].
  • The explosive growth of the World Wide Web has produced frustration for researchers seeking quality content and pinpoint results among the noise and spam [5].
  • Here we describe a peptide library-based searching algorithm, accessible over the World Wide Web, that identifies sequence motifs likely to bind to specific protein domains such as 14-3-3, SH2, and SH3 domains, or likely to be phosphorylated by specific protein kinases such as Src and AKT [6].
  • The BCM Search Launcher is an integrated set of World Wide Web (WWW) pages that organize molecular biology-related search and analysis services available on the WWW by function, and provide a single point of entry for related searches [7].
  • The databases are available through the Internet by the World-Wide Web and FTP, or on CD-ROM and magnetic media [8].

Biological context of Internet


Associations of Internet with chemical compounds

  • Prediction of secondary structure by the SSPAL method is available via Baylor College of Medicine World Wide Web server [12].
  • SETTING: World Wide Web in England and Republic of Ireland. PARTICIPANTS: A total of 3971 subjects who purchased a particular brand of nicotine patch and logged-on to use a free web-based behavioral support program [13].
  • The HLA Ligand Database is available on the world wide web at and contains ligands that have been published in peer-reviewed journals [14].
  • METHODS: The authors reviewed information about the most probable bioterrorist weapons (those from the Center for Disease Control and Prevention's Category A) from the World Wide Web and print journals and distilled it into a resource list that is current, relevant to dentistry and noncommercial [15].
  • DATA SOURCES: Human studies in English in MEDLINE, Current Contents, BIOSIS, Science Citation Index, and the popular media (including a LEXIS-NEXIS search and information from the World Wide Web and lay media) for 1966 to July 1999 using the search terms creatine, creatine supplement#, creatine monophosphate, and creatine NOT kinase [16].

Gene context of Internet

  • These mutations have been included in a MEN1-locus specific database available on the world wide web together with approximately 240 germline and somatic MEN1 mutations listed from international published data [17].
  • The program for recognition NFAT composite elements is available through the World Wide Web ( html and _comp.html) [18].
  • METHODS: All published clinical trials on selective COX-2 inhibitors were identified by searching Medline, the World Wide Web (WWW), and abstracts in Congress proceedings [19].
  • GRAP is available on the Internet (URL: +homepage.html) using the World-Wide Web system [20].
  • Chemical markup, XML, and the World Wide Web. 5. Applications of chemical metadata in RSS aggregators [21].

Analytical, diagnostic and therapeutic context of Internet

  • A multiple sequence alignment performed with 23 complete phytochrome sequences is made available via the IMB Jena World-Wide Web server ( [22].
  • This program is written using CGI/Perl scripts and has been interfaced with all the three-dimensional structures (solved using X-ray crystallography) available in the Protein Data Bank. The program, SEM, can be accessed over the World Wide Web interface at or [23].
  • The World Wide Web server of the PBIL (Pôle Bioinformatique Lyonnais) provides on-line access to sequence databanks and to many tools of nucleic acid and protein sequence analyses [24].


  1. The Factor VIII Mutation Database on the World Wide Web: the haemophilia A mutation, search, test and resource site. HAMSTeRS update (version 3.0). Kemball-Cook, G., Tuddenham, E.G. Nucleic Acids Res. (1997) [Pubmed]
  2. An interactive Web site providing major histocompatibility ligand predictions: application to HIV research. De Groot, A.S., Jesdale, B.M., Szu, E., Schafer, J.R., Chicz, R.M., Deocampo, G. AIDS Res. Hum. Retroviruses (1997) [Pubmed]
  3. Using the World Wide Web--a new approach to risk identification of diabetes mellitus. Baehring, T.U., Schulze, H., Bornstein, S.R., Scherbaum, W.A. International journal of medical informatics. (1997) [Pubmed]
  4. Cellular responses to interferon-gamma. Boehm, U., Klamp, T., Groot, M., Howard, J.C. Annu. Rev. Immunol. (1997) [Pubmed]
  5. Better searching through science. Voss, D. Science (2001) [Pubmed]
  6. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Yaffe, M.B., Leparc, G.G., Lai, J., Obata, T., Volinia, S., Cantley, L.C. Nat. Biotechnol. (2001) [Pubmed]
  7. BCM Search Launcher--an integrated interface to molecular biology data base search and analysis services available on the World Wide Web. Smith, R.F., Wiese, B.A., Wojzynski, M.K., Davison, D.B., Worley, K.C. Genome Res. (1996) [Pubmed]
  8. The PIR-International Protein Sequence Database. Barker, W.C., Garavelli, J.S., Haft, D.H., Hunt, L.T., Marzec, C.R., Orcutt, B.C., Srinivasarao, G.Y., Yeh, L.S., Ledley, R.S., Mewes, H.W., Pfeiffer, F., Tsugita, A. Nucleic Acids Res. (1998) [Pubmed]
  9. The Internal Medicine Center--an integrated solution for information on internal medicine on the World Wide Web. Kumar, G., Tan, L.H., Lun, K.C. International journal of medical informatics. (1999) [Pubmed]
  10. Prediction of operons in microbial genomes. Ermolaeva, M.D., White, O., Salzberg, S.L. Nucleic Acids Res. (2001) [Pubmed]
  11. Department of Defense Telemedicine Test Bed on the World Wide Web. Zimnik, P.R. Telemedicine journal : the official journal of the American Telemedicine Association. (1996) [Pubmed]
  12. Protein secondary structure prediction using local alignments. Salamov, A.A., Solovyev, V.V. J. Mol. Biol. (1997) [Pubmed]
  13. Randomized controlled trial of a web-based computer-tailored smoking cessation program as a supplement to nicotine patch therapy. Strecher, V.J., Shiffman, S., West, R. Addiction (2005) [Pubmed]
  14. Population of the HLA ligand database. Sathiamurthy, M., Hickman, H.D., Cavett, J.W., Zahoor, A., Prilliman, K., Metcalf, S., Fernandez Vina, M., Hildebrand, W.H. Tissue Antigens (2003) [Pubmed]
  15. Bioterrorism and catastrophe response: a quick-reference guide to resources. Han, S.Z., Alfano, M.C., Psoter, W.J., Rekow, E.D. Journal of the American Dental Association (1939) (2003) [Pubmed]
  16. Creatine: a review of efficacy and safety. Graham, A.S., Hatton, R.C. Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) (1999) [Pubmed]
  17. Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein. Wautot, V., Vercherat, C., Lespinasse, J., Chambe, B., Lenoir, G.M., Zhang, C.X., Porchet, N., Cordier, M., Béroud, C., Calender, A. Hum. Mutat. (2002) [Pubmed]
  18. Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells. Kel, A., Kel-Margoulis, O., Babenko, V., Wingender, E. J. Mol. Biol. (1999) [Pubmed]
  19. Outcome trials of COX-2 selective inhibitors: global safety evaluation does not promise benefits. Gomez Cerezo, J., Lubomirov Hristov, R., Carcas Sansuán, A.J., Vázquez Rodríguez, J.J. Eur. J. Clin. Pharmacol. (2003) [Pubmed]
  20. A database of mutants and effects of site-directed mutagenesis experiments on G protein-coupled receptors. Kristiansen, K., Dahl, S.G., Edvardsen, O. Proteins (1996) [Pubmed]
  21. Chemical markup, XML, and the World Wide Web. 5. Applications of chemical metadata in RSS aggregators. Murray-Rust, P., Rzepa, H.S., Williamson, M.J., Willighagen, E.L. Journal of chemical information and computer sciences. (2004) [Pubmed]
  22. Computer analysis of phytochrome sequences and reevaluation of the phytochrome secondary structure by Fourier transform infrared spectroscopy. Sühnel, J., Hermann, G., Dornberger, U., Fritzsche, H. Biochim. Biophys. Acta (1997) [Pubmed]
  23. SEM (Symmetry Equivalent Molecules): A web-based GUI to generate and visualize the macromolecules. Hussain, A.S., Kumar, C.h.K., Rajesh, C.K., Sheik, S.S., Sekar, K. Nucleic Acids Res. (2003) [Pubmed]
  24. Integrated databanks access and sequence/structure analysis services at the PBIL. Perrière, G., Combet, C., Penel, S., Blanchet, C., Thioulouse, J., Geourjon, C., Grassot, J., Charavay, C., Gouy, M., Duret, L., Deléage, G. Nucleic Acids Res. (2003) [Pubmed]
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