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MeSH Review

Gas Gangrene

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Disease relevance of Gas Gangrene


High impact information on Gas Gangrene


Chemical compound and disease context of Gas Gangrene


Anatomical context of Gas Gangrene


Gene context of Gas Gangrene

  • It is concluded that tissue destruction in gas gangrene is related to profound attenuation of blood flow initiated by activation of platelet responses by PLC [15].
  • Role of theta toxin, a sulfhydryl-activated cytolysin, in the pathogenesis of clostridial gas gangrene [16].
  • A 20-year literature review on gas gangrene (Part I) indicates that a combined therapy approach with early recognition, surgical intervention, appropriate antibiotics, and hyperbaric oxygen (HBO) provides optimal care [17].
  • Neither gas gangrene nor renal cell cancer has been reported previously in association with sacral chordoma [3].
  • It is suggested that these antibiotics are restricted to a small minority of patients to prevent peri-operative septicaemia and gas-gangrene [18].


  1. A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C. Flores-Díaz, M., Alape-Girón, A., Clark, G., Catimel, B., Hirabayashi, Y., Nice, E., Gutiérrez, J.M., Titball, R., Thelestam, M. J. Biol. Chem. (2005) [Pubmed]
  2. Successful treatment of mediastinal gas gangrene due to esophageal perforation. Salo, J.A., Savola, J.K., Toikkanen, V.J., Perhoniemi, V.J., Pettilä, V.Y., Klossner, J.A., Toivonen, H.J. Ann. Thorac. Surg. (2000) [Pubmed]
  3. Sacral chordoma, gas gangrene and bilateral renal cell carcinomas. Harrington, K.J., Kelly, L.F., Pandha, H.S., McKenzie, C.G. Clinical oncology (Royal College of Radiologists (Great Britain)) (1996) [Pubmed]
  4. Clostridial myonecrosis ('gas gangrene') during cephalosporin prophylaxis. Mohr, J.A., Griffiths, W., Holm, R., Garcia-Moral, C., Flournoy, D.J. JAMA (1978) [Pubmed]
  5. Letter: Gas gangrene after intramuscular injection of epinephrine: report of fatal case. Van Hook, R., Vandevelde, A.G. Ann. Intern. Med. (1975) [Pubmed]
  6. Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues. O'Brien, D.K., Melville, S.B. Infect. Immun. (2004) [Pubmed]
  7. Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens. Stevens, D.L., Titball, R.W., Jepson, M., Bayer, C.R., Hayes-Schroer, S.M., Bryant, A.E. J. Infect. Dis. (2004) [Pubmed]
  8. Effect of antibiotics on toxin production and viability of Clostridium perfringens. Stevens, D.L., Maier, K.A., Mitten, J.E. Antimicrob. Agents Chemother. (1987) [Pubmed]
  9. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. Bartlett, J.G., Onderdonk, A.B., Cisneros, R.L., Kasper, D.L. J. Infect. Dis. (1977) [Pubmed]
  10. Case report. Fatal gas gangrene following intra-articular steroid injection. Yangco, B.G., Germain, B.F., Deresinski, S.C. Am. J. Med. Sci. (1982) [Pubmed]
  11. Myonecrotic gas gangrene of the extremities. Kofoed, H., Riegels-Nielsen, P. Acta orthopaedica Scandinavica. (1983) [Pubmed]
  12. Problems with the sterilisation and the maintenance of sterility of arthroscopic instruments: a comparison of different types of camera drapes. Herzberg, W. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. (1993) [Pubmed]
  13. Chemotherapy of experimental (murine) Clostridium perfringens type A gas gangrene. Traub, W.H. Chemotherapy. (1988) [Pubmed]
  14. Metronidazole in the treatment of gas gangrene following lower limb amputation. Pashby, N.L. J. Antimicrob. Chemother. (1981) [Pubmed]
  15. Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens. Bryant, A.E., Chen, R.Y., Nagata, Y., Wang, Y., Lee, C.H., Finegold, S., Guth, P.H., Stevens, D.L. J. Infect. Dis. (2000) [Pubmed]
  16. Role of theta toxin, a sulfhydryl-activated cytolysin, in the pathogenesis of clostridial gas gangrene. Stevens, D.L., Bryant, A.E. Clin. Infect. Dis. (1993) [Pubmed]
  17. Gas gangrene. Hart, G.B., Lamb, R.C., Strauss, M.B. The Journal of trauma. (1983) [Pubmed]
  18. Are systemic prophylactic antibiotics necessary for burns? Timmons, M.J. Annals of the Royal College of Surgeons of England. (1983) [Pubmed]
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