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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sick Leave

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Disease relevance of Sick Leave

  • The aims of this study of a cross-sectional multiple sclerosis (MS) population in Västerbotten County, northern Sweden, were to estimate the prevalence of sick leave, professional assistance and housing; to study risk factors for sick leave; and to estimate the odds for sick leave in comparison with the general population of the county [1].
  • CONCLUSIONS: The results of this study indicate that acute treatment with high-dose methylprednisolone may be beneficial in preventing extensive sick leave after whiplash injury [2].
  • COPD patients, who had informed the employer or colleagues about the disease, who did not have difficult tasks at work, who did not hide dyspnea and limitations, and who reported high fatigue were showing higher sick leave [3].
  • SUMMARY OF BACKGROUND DATA: Light multidisciplinary programs seem to reduce sick leave in patients with subacute low back pain [4].
  • In the TAPP group postoperative pain and analgesic consumption were less, postoperative functional status was better, and sick leave was shorter (10 vs. 14 days) [5].

High impact information on Sick Leave

  • After a 5-year followup, the cumulative number of days of sick leave and RA-related permanent work disability was calculated for each of the 162 patients who were available for the active work force at baseline [6].
  • Prognostic factors for the occurrence of longterm disability and prolonged sick leave were determined in 182 patients with ankylosing spondylitis [7].
  • Amantadine costs $9.06 per illness day avoided or $11.60 per quality-adjusted day gained [8].
  • Compared with amantadine, zanamivir costs $198 per illness day avoided or $185 per quality-adjusted day gained, whereas oseltamivir costs $252 per illness day avoided or $235 per quality-adjusted day gained [8].
  • Of the known diabetic patients, > 80% recalled having been instructed as to blood glucose testing and acute and chronic complications, but fewer patients recalled having been instructed as to insulin dose adjustment (28%) or sick day management (35%) [9].

Biological context of Sick Leave

  • Awareness was defined as answering positively to the question 'did a physician ever tell you that your blood pressure/serum cholesterol was too high?' Sick leave data were independently and objectively recorded during 1 year following the screening [10].

Anatomical context of Sick Leave

  • Total sick-leave cost in Norway associated with surgical third-molar removals, adjusted for age-related income, employment rate, treatment rate, and provider of treatment, was 46.4 million NOK per year [11].

Associations of Sick Leave with chemical compounds

  • Insufficiently frequent blood glucose monitoring, failure by patients to detect mechanical and technical problems with infusion systems, failure to adhere to "sick day" regimens, and delay in seeking medical help all contributed to the progression of a number of episodes [12].
  • RESULTS--Multidisciplinary diabetes team residents were significantly more positive about the roles for endocrinological evaluation in monitoring compliance, for the nurse educator/certified diabetes educator in assisting with sick-day management and school behavioral problems, and for the dietician in helping with cholesterol problems [13].
  • Although urine testing for ketones has been the standard approach to sick-day management, new technology for self-monitoring of blood 3HB levels is now available [14].
  • Number of days on sick leave decreased significantly in the sulphasalazine group only (P < 0.01) [15].
  • This study demonstrates a significant reduction in sick-leave days after four months of NAC-treatment [16].

Gene context of Sick Leave

  • A decreased expression of CD25 correlates linearly with increasing SIS and with a higher number of sick days with URI [17].
  • Knowledge about asthma and COPD: associations with sick leave, health complaints, functional limitations, adaptation, and perceived control [18].
  • Costs due to RA-related sick leave, work disability, and other work loss were assessed using the human capital approach [19].
  • This may explain the reduction in days of sick leave seen during GH therapy [20].
  • Infected evaluable subjects who received treatment had reduced rhinorrhea scores (compared with those who received placebo) on illness days 2 (0.7 vs. 1.0; P = .04) and 3 (0.6 vs. 0.9; P = .04) and had reduced nasal secretion weights on day 3 (3.6 g vs. 6.3 g; P = .03) [21].

Analytical, diagnostic and therapeutic context of Sick Leave

  • Salivary cortisol was not affected by age, body mass index, gender, smoking habits or days of sick leave during the past year [22].
  • Nevertheless, IVF/ICSI twin mothers were more frequently on sick leave (OR 2.5, 95% CI 1.5-4.0) and hospitalized (OR 1.9, 95% CI 1.3-2.8) during pregnancy [23].
  • We collected and compared the data of clinic visits and hours of sick leave among vaccinated and non-vaccinated workers during January and April in 1998 and 1999 [24].


  1. Sick leave and professional assistance for multiple sclerosis individuals in Västerbotten County, northern Sweden. Sundström, P., Nyström, L., Svenningsson, A., Forsgren, L. Mult. Scler. (2003) [Pubmed]
  2. High-dose methylprednisolone prevents extensive sick leave after whiplash injury. A prospective, randomized, double-blind study. Pettersson, K., Toolanen, G. Spine. (1998) [Pubmed]
  3. Sick leave in patients with obstructive lung disease is related to psychosocial and work variables rather than to FEV1. Boot, C.R., Vercoulen, J.H., van der Gulden, J.W., Orbon, K.H., van den Hoogen, H., Folgering, H.T. Respiratory medicine. (2005) [Pubmed]
  4. Relative cost-effectiveness of extensive and light multidisciplinary treatment programs versus treatment as usual for patients with chronic low back pain on long-term sick leave: randomized controlled study. Skouen, J.S., Grasdal, A.L., Haldorsen, E.M., Ursin, H. Spine. (2002) [Pubmed]
  5. Postoperative convalescence after inguinal hernia surgery: prospective randomized multicenter study of laparoscopic versus shouldice inguinal hernia repair in 1042 patients. Berndsen, F., Arvidsson, D., Enander, L.K., Leijonmarck, C.E., Wingren, U., Rudberg, C., Smedberg, S., Wickbom, G., Montgomery, A. Hernia : the journal of hernias and abdominal wall surgery. (2002) [Pubmed]
  6. Early suppression of disease activity is essential for maintenance of work capacity in patients with recent-onset rheumatoid arthritis: five-year experience from the FIN-RACo trial. Puolakka, K., Kautiainen, H., Möttönen, T., Hannonen, P., Korpela, M., Hakala, M., Järvinen, P., Ahonen, J., Forsberg, S., Leirisalo-Repo, M. Arthritis Rheum. (2005) [Pubmed]
  7. Long-term disability and prolonged sick leaves as outcome measurements in ankylosing spondylitis. Possible predictive factors. Guillemin, F., Briançon, S., Pourel, J., Gaucher, A. Arthritis Rheum. (1990) [Pubmed]
  8. Cost-effectiveness of newer treatment strategies for influenza. Smith, K.J., Roberts, M.S. Am. J. Med. (2002) [Pubmed]
  9. Diabetes in urban African-Americans. I. Cessation of insulin therapy is the major precipitating cause of diabetic ketoacidosis. Musey, V.C., Lee, J.K., Crawford, R., Klatka, M.A., McAdams, D., Phillips, L.S. Diabetes Care (1995) [Pubmed]
  10. Increased absenteeism from work among aware and treated hypertensive and hypercholesterolaemic patients. Leynen, F., De Backer, G., Pelfrene, E., Clays, E., Kittel, F., Moreau, M., Kornitzer, M. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. (2006) [Pubmed]
  11. Inability to work after surgical removal of mandibular third molars. Berge, T.I. Acta Odontol. Scand. (1997) [Pubmed]
  12. Diabetic ketoacidosis during long-term treatment with continuous subcutaneous insulin infusion. Peden, N.R., Braaten, J.T., McKendry, J.B. Diabetes Care (1984) [Pubmed]
  13. Impact of resident participation in a multidisciplinary diabetes team. Gray, D.L., Langefeld, C.D., Golden, M.P., Orr, D.P. Diabetes Care (1993) [Pubmed]
  14. Sick-day management in type 1 diabetes. Laffel, L. Endocrinol. Metab. Clin. North Am. (2000) [Pubmed]
  15. Limited effect of sulphasalazine treatment in reactive arthritis. A randomised double blind placebo controlled trial. Egsmose, C., Hansen, T.M., Andersen, L.S., Beier, J.M., Christensen, L., Ejstrup, L., Peters, N.D., van der Heijde, D.M. Ann. Rheum. Dis. (1997) [Pubmed]
  16. Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis. Rasmussen, J.B., Glennow, C. Eur. Respir. J. (1988) [Pubmed]
  17. The influence of stress intrusion on immunodepression in generalized anxiety disorder patients and controls. La Via, M.F., Munno, I., Lydiard, R.B., Workman, E.W., Hubbard, J.R., Michel, Y., Paulling, E. Psychosomatic medicine. (1996) [Pubmed]
  18. Knowledge about asthma and COPD: associations with sick leave, health complaints, functional limitations, adaptation, and perceived control. Boot, C.R., van der Gulden, J.W., Vercoulen, J.H., van den Borne, B.H., Orbon, K.H., Rooijackers, J., van Weel, C., Folgering, H.T. Patient education and counseling. (2005) [Pubmed]
  19. Indirect medical costs in early rheumatoid arthritis: composition of and changes in indirect costs within the first three years of disease. Merkesdal, S., Ruof, J., Schöffski, O., Bernitt, K., Zeidler, H., Mau, W. Arthritis Rheum. (2001) [Pubmed]
  20. Long-term growth hormone replacement therapy in hypopituitary adults. Verhelst, J., Abs, R. Drugs (2002) [Pubmed]
  21. Randomized controlled trial of clemastine fumarate for treatment of experimental rhinovirus colds. Gwaltney, J.M., Park, J., Paul, R.A., Edelman, D.A., O'Connor, R.R., Turner, R.B. Clin. Infect. Dis. (1996) [Pubmed]
  22. Evaluation of a radioimmunoassay and establishment of a reference interval for salivary cortisol in healthy subjects in Denmark. Hansen, A.M., Garde, A.H., Christensen, J.M., Eller, N.H., Netterstrøm, B. Scand. J. Clin. Lab. Invest. (2003) [Pubmed]
  23. Maternal risks and perinatal outcome in a Danish national cohort of 1005 twin pregnancies: the role of in vitro fertilization. Pinborg, A., Loft, A., Schmidt, L., Langhoff-Roos, J., Andersen, A.N. Acta obstetricia et gynecologica Scandinavica. (2004) [Pubmed]
  24. Reduction of acute respiratory illness (ARI) due to a voluntary workplace influenza vaccination program: who are more likely to get the benefit? Liu, Y.H., Huang, L.M., Wang, J.D. Journal of occupational health. (2004) [Pubmed]
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