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MeSH Review

Sperm Injections, Intracytoplasmic

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Disease relevance of Sperm Injections, Intracytoplasmic


Psychiatry related information on Sperm Injections, Intracytoplasmic

  • (1998) reported that children conceived after ICSI had lower scores in the Mental Development Index (MDI) of the Bayley Scales of Infant Development compared with infants conceived naturally or by standard IVF treatment [6].
  • RESULTS: A significant relationship was shown between baseline psychological factors and the probability to become pregnant after IVF/intracytoplasmic sperm injection (ICSI) treatment, controlling for other factors [7].

High impact information on Sperm Injections, Intracytoplasmic

  • Mean associated laboratory time was significantly shorter with IVF than with ICSI (22.9 [SD 12.1] vs 74.0 [38.1] min; 95% CI for difference 45.6-56.6) [8].
  • Decrease in testosterone blood concentrations after testicular sperm extraction for intracytoplasmic sperm injection in azoospermic men [9].
  • Because intracytoplasmic sperm injection is increasingly used as a means of circumventing oligozoospermia, AZF deletions could be transmitted by this practice, and would probably result in infertile sons [10].
  • As genetic abnormalities are present in a significant percentage of infertile males with impaired spermatogenesis, karyotyping and analysis of the Y chromosome for microdeletions should be carried out in all potential ICSI fathers [11].
  • These findings indicate that the injection of somatic cytoplasm into oocytes before ICSI causes a decrease in preimplantation development, clearly impairs full-term development, and causes placental overgrowth in fertilized embryos [12].

Chemical compound and disease context of Sperm Injections, Intracytoplasmic


Biological context of Sperm Injections, Intracytoplasmic

  • Intracytoplasmic sperm injection (ICSI) is a promising assisted-fertilisation technique that may benefit women who have not become pregnant by in-vitro fertilisation (IVF) or subzonal insemination (SUZI) of oocytes [1].
  • The results of the present study demonstrate that ICSI does not enhance the azh mutation phenotype in the offspring and brings no risks when applied continuously [18].
  • IVF/ICSI twin pregnancies: risks and prevention [19].
  • The patients with ICSI were more likely to have aneuploidy identified in their POC than conventional IVF, 76% vs. 41% [20].
  • BACKGROUND: The objective of this review was to investigate whether ICSI improves live-birth rate in comparison with IVF in couples with non-male factor subfertility [21].

Anatomical context of Sperm Injections, Intracytoplasmic


Associations of Sperm Injections, Intracytoplasmic with chemical compounds


Gene context of Sperm Injections, Intracytoplasmic


Analytical, diagnostic and therapeutic context of Sperm Injections, Intracytoplasmic


  1. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Palermo, G., Joris, H., Devroey, P., Van Steirteghem, A.C. Lancet (1992) [Pubmed]
  2. Clinical use of pentoxifylline for activation of immotile testicular sperm before ICSI in patients with azoospermia. Kovacic, B., Vlaisavljevic, V., Reljic, M. J. Androl. (2006) [Pubmed]
  3. Therapeutic approach of immotile cilia syndrome by intracytoplasmic sperm injection: a case report. Papadimas, J., Tarlatzis, B.C., Bili, H., Sotiriadis, T., Koliakou, K., Bontis, J., Mantalenakis, S. Fertil. Steril. (1997) [Pubmed]
  4. Impact of endometrioma resection prior to IVF/ICSI cycles. Garcia-Velasco, J.A., Arici, A., Pellicer, A. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  5. Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10,362 non-IVF/ICSI twins born between 1995 and 2000. Pinborg, A., Loft, A., Rasmussen, S., Schmidt, L., Langhoff-Roos, J., Greisen, G., Andersen, A.N. Hum. Reprod. (2004) [Pubmed]
  6. Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents. Papaligoura, Z., Panopoulou-Maratou, O., Solman, M., Arvaniti, K., Sarafidou, J. Hum. Reprod. (2004) [Pubmed]
  7. The effect of anxiety and depression on the outcome of in-vitro fertilization. Smeenk, J.M., Verhaak, C.M., Eugster, A., van Minnen, A., Zielhuis, G.A., Braat, D.D. Hum. Reprod. (2001) [Pubmed]
  8. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial. Bhattacharya, S., Hamilton, M.P., Shaaban, M., Khalaf, Y., Seddler, M., Ghobara, T., Braude, P., Kennedy, R., Rutherford, A., Hartshorne, G., Templeton, A. Lancet (2001) [Pubmed]
  9. Decrease in testosterone blood concentrations after testicular sperm extraction for intracytoplasmic sperm injection in azoospermic men. Manning, M., Jünemann, K.P., Alken, P. Lancet (1998) [Pubmed]
  10. Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome. Reijo, R., Alagappan, R.K., Patrizio, P., Page, D.C. Lancet (1996) [Pubmed]
  11. Clinical review 100: Evaluation and treatment of the infertile couple. Forti, G., Krausz, C. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  12. Injection of somatic cell cytoplasm into oocytes before intracytoplasmic sperm injection impairs full-term development and increases placental weight in mice. Van Thuan, N., Wakayama, S., Kishigami, S., Ohta, H., Hikichi, T., Mizutani, E., Bui, H.T., Wakayama, T. Biol. Reprod. (2006) [Pubmed]
  13. Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study. Hussein, A., Ozgok, Y., Ross, L., Niederberger, C. J. Androl. (2005) [Pubmed]
  14. Sequential assessment of individually cultured human embryos as an indicator of subsequent good quality blastocyst development. Neuber, E., Rinaudo, P., Trimarchi, J.R., Sakkas, D. Hum. Reprod. (2003) [Pubmed]
  15. Medically assisted reproduction and second-trimester maternal serum marker screening for Down syndrome. Muller, F., Dreux, S., Lemeur, A., Sault, C., Desgrès, J., Bernard, M.A., Giorgetti, C., Lemay, C., Mirallié, S., Beauchet, A. Prenat. Diagn. (2003) [Pubmed]
  16. Obesity and Clomiphene Challenge Test as predictors of outcome of in vitro fertilization and intracytoplasmic sperm injection. van Swieten, E.C., van der Leeuw-Harmsen, L., Badings, E.A., van der Linden, P.J. Gynecol. Obstet. Invest. (2005) [Pubmed]
  17. Update on clinical trials of cystic fibrosis. Henig, N.R., Aitken, M.L. Current opinion in pulmonary medicine. (1997) [Pubmed]
  18. Intracytoplasmic sperm injection effects in infertile azh mutant mice. Ward, M.A. Biol. Reprod. (2005) [Pubmed]
  19. IVF/ICSI twin pregnancies: risks and prevention. Pinborg, A. Hum. Reprod. Update (2005) [Pubmed]
  20. Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection. Lathi, R.B., Milki, A.A. Fertil. Steril. (2004) [Pubmed]
  21. ICSI versus conventional techniques for oocyte insemination during IVF in patients with non-male factor subfertility: a Cochrane review. van Rumste, M.M., Evers, J.L., Farquhar, C.M. Hum. Reprod. (2004) [Pubmed]
  22. Presence and localization of oscillin in human spermatozoa in relation to the integrity of the sperm membrane. Montag, M., Parrington, J., Swann, K., Lai, F.A., van der Ven, H. FEBS Lett. (1998) [Pubmed]
  23. Establishment of embryonic stem cell lines from cynomolgus monkey blastocysts produced by IVF or ICSI. Suemori, H., Tada, T., Torii, R., Hosoi, Y., Kobayashi, K., Imahie, H., Kondo, Y., Iritani, A., Nakatsuji, N. Dev. Dyn. (2001) [Pubmed]
  24. High frequency of defective sperm-zona pellucida interaction in oligozoospermic infertile men. Liu, d.e. .Y., Baker, H.W. Hum. Reprod. (2004) [Pubmed]
  25. Number of good quality embryos on day 3 is predictive for both pregnancy and implantation rates in in vitro fertilization/intracytoplasmic sperm injection cycles. Volpes, A., Sammartano, F., Coffaro, F., Mistretta, V., Scaglione, P., Allegra, A. Fertil. Steril. (2004) [Pubmed]
  26. Relationship between steroid concentrations in ovarian follicular fluid and oocyte morphology in patients undergoing intracytoplasmic sperm injection (ICSI) treatment. Xia, P., Younglai, E.V. J. Reprod. Fertil. (2000) [Pubmed]
  27. Human sperm aster formation and pronuclear decondensation in bovine eggs following intracytoplasmic sperm injection using a Piezo-driven pipette: a novel assay for human sperm centrosomal function. Nakamura, S., Terada, Y., Horiuchi, T., Emuta, C., Murakami, T., Yaegashi, N., Okamura, K. Biol. Reprod. (2001) [Pubmed]
  28. Similar time restriction for intracytoplasmic sperm injection and round spermatid injection into activated oocytes for efficient offspring production. Kishigami, S., Wakayama, S., Nguyen, V.T., Wakayama, T. Biol. Reprod. (2004) [Pubmed]
  29. Intracytoplasmic sperm injection with polyvinylpyrrolidone: a potential risk. Jean, M., Mirallié, S., Boudineau, M., Tatin, C., Barrière, P. Fertil. Steril. (2001) [Pubmed]
  30. A prospective randomized comparison of routine buserelin acetate and a decreasing dosage of nafarelin acetate with a low-dose gonadotropin-releasing hormone agonist protocol for in vitro fertilization and intracytoplasmic sperm injection. Takeuchi, S., Minoura, H., Shibahara, T., Tsuiki, Y., Noritaka, F., Toyoda, N. Fertil. Steril. (2001) [Pubmed]
  31. Altered protamine 2 expression is uncommon in donors of known fertility, but common among men with poor fertilizing capacity, and may reflect other abnormalities of spermiogenesis. Carrell, D.T., Liu, L. J. Androl. (2001) [Pubmed]
  32. Follicular fluid levels of vascular endothelial growth factor and leptin are associated with pregnancy outcome of normal women participating in intracytoplasmic sperm injection cycles. Asimakopoulos, B., Nikolettos, N., Papachristou, D.N., Simopoulou, M., Al-Hasani, S., Diedrich, K. Physiological research / Academia Scientiarum Bohemoslovaca. (2005) [Pubmed]
  33. Assessment of seminiferous tubule function (anti-müllerian hormone). Rey, R. Baillière's best practice & research. Clinical endocrinology & metabolism. (2000) [Pubmed]
  34. Offspring from normal mouse oocytes injected with sperm heads from the azh/azh mouse display more severe sperm tail abnormalities than the original mutant. Akutsu, H., Tres, L.L., Tateno, H., Yanagimachi, R., Kierszenbaum, A.L. Biol. Reprod. (2001) [Pubmed]
  35. Screening for microdeletions of Y chromosome genes in patients undergoing intracytoplasmic sperm injection. Krausz, C., Bussani-Mastellone, C., Granchi, S., McElreavey, K., Scarselli, G., Forti, G. Hum. Reprod. (1999) [Pubmed]
  36. Should vasectomy reversal be performed in men with older female partners? Deck, A.J., Berger, R.E. J. Urol. (2000) [Pubmed]
  37. A successful pregnancy after intracytoplasmic sperm injection and embryo transfer in a patient with endometrial cancer who was treated conservatively. Yarali, H., Bozdag, G., Aksu, T., Ayhan, A. Fertil. Steril. (2004) [Pubmed]
  38. Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotrophic women undergoing assisted reproduction. Westergaard, L.G., Laursen, S.B., Andersen, C.Y. Hum. Reprod. (2000) [Pubmed]
  39. Pregnancy following chemical activation of oocytes in a couple with repeated failure of fertilization using ICSI: case report. Murase, Y., Araki, Y., Mizuno, S., Kawaguchi, C., Naito, M., Yoshizawa, M., Araki, Y. Hum. Reprod. (2004) [Pubmed]
  40. Patients' attitudes towards donation of surplus cryopreserved embryos for treatment or research. Bangsbøll, S., Pinborg, A., Yding Andersen, C., Nyboe Andersen, A. Hum. Reprod. (2004) [Pubmed]
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