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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Gonadoblastoma


High impact information on Gonadoblastoma


Chemical compound and disease context of Gonadoblastoma


Biological context of Gonadoblastoma

  • Minute Y chromosome derived marker in a child with gonadoblastoma: cytogenetic and DNA studies [14].
  • In two female patients with gonadoblastoma, small marker chromosomes contained portions of the Y chromosome, and a single region of overlap could be defined extending from probe pDP97 in interval 4B, which contains the centromere, to marker sY182 in interval 5E of the proximal long arm [15].
  • One out of five female patients with mutations in WT1 developed a WT, 2/3 male patients presented with the association of urinary and genital malformations, 1/3 male patients presented with sexual reversal (female phenotype) and bilateral gonadoblastoma, and 4/5 female patients presented with isolated SRNS [16].

Anatomical context of Gonadoblastoma

  • Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY [17].

Gene context of Gonadoblastoma


Analytical, diagnostic and therapeutic context of Gonadoblastoma


  1. XY gonadal dysgenesis and gonadoblastoma: a study in two sisters with a cryptic deletion of the Y chromosome involving the SRY gene. Barbosa, A.S., Ferraz-Costa, T.E., Semer, M., Liberman, B., Moreira-Filho, C.A. Hum. Genet. (1995) [Pubmed]
  2. PCR-based study of the presence of Y-chromosome sequences in patients with Ullrich-Turner syndrome. Coto, E., Toral, J.F., Menéndez, M.J., Hernando, I., Plasencia, A., Benavides, A., López-Larrea, C. Am. J. Med. Genet. (1995) [Pubmed]
  3. Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads. Rajpert-De Meyts, E., Hanstein, R., Jørgensen, N., Graem, N., Vogt, P.H., Skakkebaek, N.E. Hum. Reprod. (2004) [Pubmed]
  4. CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein. Krick, R., Aschrafi, A., Hasgün, D., Arnemann, J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. Mixed gonadal dysgenesis and precocious puberty. Iliev, D.I., Ranke, M.B., Wollmann, H.A. Horm. Res. (2002) [Pubmed]
  6. Letter: Gonadoblastoma in dysgenetic gonads with a Y chromosome. Philip, J. Lancet (1975) [Pubmed]
  7. Letter: Gonadoblastoma in dysgenetic gonads with a Y chromosome. Mulvihill, J., Wade, W.M., Miller, R.W. Lancet (1975) [Pubmed]
  8. Testicular dysgenesis does not affect expression of anti-müllerian hormone by Sertoli cells in premeiotic seminiferous tubules. Rey, R., al-Attar, L., Louis, F., Jaubert, F., Barbet, P., Nihoul-Fékété, C., Chaussain, J.L., Josso, N. Am. J. Pathol. (1996) [Pubmed]
  9. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. Hoei-Hansen, C.E., Sehested, A., Juhler, M., Lau, Y.F., Skakkebaek, N.E., Laursen, H., Rajpert-de Meyts, E. J. Pathol. (2006) [Pubmed]
  10. Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development. Honecker, F., Kersemaekers, A.M., Molier, M., Van Weeren, P.C., Stoop, H., De Krijger, R.R., Wolffenbuttel, K.P., Oosterhuis, W., Bokemeyer, C., Looijenga, L.H. J. Pathol. (2004) [Pubmed]
  11. Ovarian and peripheral venous steroids in XY gonadal dysgenesis and gonadoblastoma. McDonough, P.G., Ellegood, J.O., Byrd, J.R., Mahesh, V.B. Obstetrics and gynecology. (1976) [Pubmed]
  12. Bilateral gonadoblastoma producing steroid hormones in a patient with 45,X/46,XY gonadal dysgenesis. Fukamatsu, Y., Tsukahara, Y., Hayashi, S., Yoshikawa, F., Fukuta, T. Gynecol. Obstet. Invest. (1990) [Pubmed]
  13. Gonadoblastoma in androgen insensitivity syndrome: a case report. Raspagliesi, F., Ditto, A., Cobellis, L., Quattrone, P., Fontanelli, R., Kusamura, S., Solima, E. Tumori. (2003) [Pubmed]
  14. Minute Y chromosome derived marker in a child with gonadoblastoma: cytogenetic and DNA studies. Petrovic, V., Nasioulas, S., Chow, C.W., Voullaire, L., Schmidt, M., Dahl, H. J. Med. Genet. (1992) [Pubmed]
  15. Molecular mapping of the putative gonadoblastoma locus on the Y chromosome. Salo, P., Kääriäinen, H., Petrovic, V., Peltomäki, P., Page, D.C., de la Chapelle, A. Genes Chromosomes Cancer (1995) [Pubmed]
  16. Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome. Ruf, R.G., Schultheiss, M., Lichtenberger, A., Karle, S.M., Zalewski, I., Mucha, B., Everding, A.S., Neuhaus, T., Patzer, L., Plank, C., Haas, J.P., Ozaltin, F., Imm, A., Fuchshuber, A., Bakkaloglu, A., Hildebrandt, F. Kidney Int. (2004) [Pubmed]
  17. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Kersemaekers, A.M., Honecker, F., Stoop, H., Cools, M., Molier, M., Wolffenbuttel, K., Bokemeyer, C., Li, Y., Lau, Y.F., Oosterhuis, J.W., Looijenga, L.H. Hum. Pathol. (2005) [Pubmed]
  18. Gonadoblastoma: immunohistochemical localization of Müllerian-inhibiting substance, inhibin, WT-1, and p53. Hussong, J., Crussi, F.G., Chou, P.M. Mod. Pathol. (1997) [Pubmed]
  19. Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex-reversion in a 46,XY female. Müller, J., Schwartz, M., Skakkebaek, N.E. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  20. Characterization of novel genes in AZF regions. Stuppia, L., Gatta, V., Fogh, I., Gaspari, A.R., Grande, R., Morizio, E., Fantasia, D., Pizzuti, A., Calabrese, G., Palka, G. J. Endocrinol. Invest. (2000) [Pubmed]
  21. Ectopic prolactin secretion from a gonadoblastoma. Hoffman, W.H., Gala, R.R., Kovacs, K., Subramanian, M.G. Cancer (1987) [Pubmed]
  22. Occurrence of gonadoblastoma in females with Turner syndrome and Y chromosome material: a population study. Gravholt, C.H., Fedder, J., Naeraa, R.W., Müller, J. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  23. In situ hybridization analysis of the Y chromosome in gonadoblastoma. Sultana, R., Myerson, D., Disteche, C.M. Genes Chromosomes Cancer (1995) [Pubmed]
  24. Gonadoblastoma in infancy: indications for early gonadectomy in 46XY gonadal dysgenesis. Olsen, M.M., Caldamone, A.A., Jackson, C.L., Zinn, A. J. Pediatr. Surg. (1988) [Pubmed]
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