Disease relevance of Streptococcus equi

• On the basis of phenotypic and molecular genetic evidence, it is proposed that the unknown Streptococcus isolates from ovine and caprine mastitis be classified as a novel subspecies, Streptococcus equi subsp. ruminatorum subsp. nov [1].
• BACKGROUND: In 1998, there was a large outbreak of acute glomerulonephritis in Nova Serrana, Brazil, caused by group C Streptococcus zooepidemicus [2].
• The capsules of Corynebacterium equi and Streptococcus equi were examined by electron microscopy after staining with ruthenium red [3].

High impact information on Streptococcus equi

• The same species (Streptococcus zooepidemicus) that was isolated from the CSF of the patient also grew from the pharynx of the patient's horse [4].
• Studies of fibronectin-binding proteins of Streptococcus equi [5].
• None of 10 T3 isolates recovered during or before 1973 has speL, whereas all of 18 M3/T3 isolates recovered during or after 1992 and, surprisingly, Streptococcus equi subsp. equi ATCC 9527 do have this gene [6].
• Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus [7].
• Streptokinases secreted by nonhuman isolates of group C streptococci (Streptococcus equi, S. equisimilis, and S. zooepidemicus) have been shown to bind to different mammalian plasminogens but exhibit preferential plasminogen activity [8].

Chemical compound and disease context of Streptococcus equi

• Inhibition of C3 deposition on Streptococcus equi subsp. equi by M protein: a mechanism for survival in equine blood [9].
• Stable production of hyaluronic acid in Streptococcus zooepidemicus chemostats operated at high dilution rate [10].
• Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone [11].
• Identification of methionine-processed HPr in the equine pathogen Streptococcus equi [12].
• The function of blood and uterine luminal neutrophils from ovariectomized mares treated with ovarian steroids was investigated 18 h after intrauterine infusion of 1 X 10(9) Streptococcus zooepidemicus [13].

Biological context of Streptococcus equi

• The N-terminal fragment (FNZN) of the fibronectin-binding protein FNZ from Streptococcus equi subspecies zooepidemicus was investigated as to effects on murine cell interactions with extracellular matrix proteins [14].

Anatomical context of Streptococcus equi

• As observed previously in cultured human skin fibroblasts, a decrease of hyaluronan production was also observed in group C Streptococcus equi FM100 cells treated with 4-methylumbelliferone (MU), although there was no effect on their growth [11].

Gene context of Streptococcus equi

• The group C streptococcal species Streptococcus equisimilis, Streptococcus zooepidemicus, Streptococcus equi, and Streptococcus dysgalactiae were uniformly reactive with fibronectin [15].
• Fibronectin-binding protein of Streptococcus equi subsp. zooepidemicus [16].
• Demonstration of a new type of immunoglobulin G receptor in Streptococcus zooepidemicus strains [17].
• All 5 had been exposed to Streptococcus equi within 3 weeks prior to examination or had high serum titers of antibodies against the M protein of S equi [18].

Analytical, diagnostic and therapeutic context of Streptococcus equi

• Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system [19].
• Small animal models of Streptococcus equi infection have been confined to parenteral injection of mice which subsequently develop a septicaemia [20].

References