Disease relevance of Apudoma

• 90 neuroendocrine neoplasias (APUDomas) (including islet-cell tumours, phaeochromocytomas, medullary thyroid carcinomas, oat-cell tumours, and APUDomas of the gut, pancreas, and lung) reacted strongly with antisera to NSE [1].
• In the present study, a group of 18 patients with carcinoid tumours and gastrointestinal (GI) apudomas was investigated to assess the accuracy of Octreotide scintigraphy in localizing primitive, recurrent or metastatic lesions [2].
• Observations on the effect of a somatostatin analog in the Zollinger-Ellison syndrome: implications for the treatment of apudomas [3].
• Nine patients with pancreatic apudomas (seven gastrinomas, one glucagonoma, one tumor secreting a substance P-like component) and nine with metastasized carcinoid tumors were treated with a somatostatin analogue (SMS 201-995), administered subcutaneously twice daily for 3 days [4].
• A patient is described who presented with the classical symptomatology and profound electrolyte disturbance of the Verner-Morrison syndrome due to a pancreatic apudoma secreting vasoactive intestinal polypeptide (VIP) [5].

High impact information on Apudoma

• Thus NSE, a specific enzyme produced in the neural and endocrine systems, was found to be produced in considerable quantities by all types of APUDomas but not in any non-endocrine tumours [1].
• Two patients with pancreatic apudomas secreting neurotensin and VIP [6].
• Mixed pancreatic apudoma with symptoms of excess vasoactive intestinal polypeptide and insulin: improvement of diarrhoea with metoclopramide [7].
• The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder [8].
• Mitoxantrone in metastatic apudomas: a phase II study of the EORTC Gastro-Intestinal Cancer Cooperative Group [9].

Chemical compound and disease context of Apudoma

• Effective streptozocin therapy for metastatic pancreatic polypeptide apudoma [10].
• Doxorubicin plus cisplatin in the treatment of apudomas [11].
• Thus, the chemo-responsiveness of MTC may be akin to that of other APUD carcinomas (APUDomas) and treatment of metastatic MTC and other APUDomas with the combination of dacarbazine and 5-fluorouracil appears to merit further study [12].
• Apudomas and the gastro-intestinal tract [13].

Gene context of Apudoma

• Pancreatic-polypeptide-producing apudoma of the liver [14].
• The long-acting somatostatin (SMS) analog, SMS 201-995 has beneficial effects on APUDomas [15].
• Although the significance of such discrepancies in reactivity with HNK-1 antibody remains unknown, the present results suggest that some of the gynecologic tumors with argyrophilia are related to APUDomas [16].
• Survey sera from an expanded pool of 23 patients with islet cell tumors and nine with carcinoid tumors did not identify additional cases, however, suggesting that elevated AFP levels in these classes of Apudomas are uncommon [17].

References