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MeSH Review

Pair Bond

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Psychiatry related information on Pair Bond


High impact information on Pair Bond

  • OT exerts potent antistress effects that may facilitate pair bonds [2].
  • Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds [3].
  • Due to steric hindrance, an adenine-thymine-type hydrogen bond pair is formed only at potentials more positive than 0.1 V (vs SCE) where the unprotonated adenine moiety is perpendicularly oriented [4].
  • These results suggest possible sites of action for CRF-induced facilitation of pair bond formation in prairie voles, as well as potential sex differences in the CRF modulation of pair bonding [5].
  • However, it is unclear which brain circuits are involved in this vasopressin-mediated facilitation of pair bond formation [6].

Chemical compound and disease context of Pair Bond

  • Concurrent activation of neuropeptide and dopamine receptors in the reward centers of the brain during mating results in a conditioned partner preference, observed as a pair bond [7].
  • These receptors have also been implicated in the behavioral differences relevant to monogamy, as oxytocin and vasopressin influence pair-bond formation in the monogamous species [8].
  • Results confirmed that cortisol concentrations were reduced following the establishment of a pair-bond and found that P. campbelli males had elevated cortisol before the birth [9].
  • Pair bond formation occurred between September and December and was associated with an increase in levels of plasma LH but no change in plasma estradiol [10].
  • However, many investigations indicate that pair bonds in nonsexual contexts are not regulated by testosterone [11].

Biological context of Pair Bond


Anatomical context of Pair Bond

  • The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole [3].
  • Next, we infused a selective V1aR antagonist into three candidate brain regions that seemed most likely involved in vasopressin-mediated pair bond formation: the ventral pallidum, medial amygdala, and MDthal [6].
  • Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous vole [13].

Gene context of Pair Bond


Analytical, diagnostic and therapeutic context of Pair Bond


  1. Maternally modulated infant separation responses are regulated by D2-family dopamine receptors. Muller, J.M., Brunelli, S.A., Moore, H., Myers, M.M., Shair, H.N. Behav. Neurosci. (2005) [Pubmed]
  2. The oxytocin receptor system: structure, function, and regulation. Gimpl, G., Fahrenholz, F. Physiol. Rev. (2001) [Pubmed]
  3. Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds. Aragona, B.J., Liu, Y., Yu, Y.J., Curtis, J.T., Detwiler, J.M., Insel, T.R., Wang, Z. Nat. Neurosci. (2006) [Pubmed]
  4. In situ surface-enhanced infrared study of hydrogen bond pairing of complementary nucleic acid bases at the electrochemical interface. Sato, Y., Noda, H., Mizutani, F., Yamakata, A., Osawa, M. Anal. Chem. (2004) [Pubmed]
  5. Species and sex differences in brain distribution of corticotropin-releasing factor receptor subtypes 1 and 2 in monogamous and promiscuous vole species. Lim, M.M., Nair, H.P., Young, L.J. J. Comp. Neurol. (2005) [Pubmed]
  6. Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole. Lim, M.M., Young, L.J. Neuroscience (2004) [Pubmed]
  7. The neurobiology of pair bonding. Young, L.J., Wang, Z. Nat. Neurosci. (2004) [Pubmed]
  8. Immunoreactivity of central vasopressin and oxytocin pathways in microtine rodents: a quantitative comparative study. Wang, Z., Zhou, L., Hulihan, T.J., Insel, T.R. J. Comp. Neurol. (1996) [Pubmed]
  9. Hormonal changes in males of a naturally biparental and a uniparental mammal. Reburn, C.J., Wynne-Edwards, K.E. Hormones and behavior. (1999) [Pubmed]
  10. Environmental, dietary, and hormonal factors in the regulation of seasonal breeding in free-living female Indian rose-ringed parakeets (Psittacula krameri). Sailaja, R., Kotak, V.C., Sharp, P.J., Schmedemann, R., Haase, E. Hormones and behavior. (1988) [Pubmed]
  11. Ecological constraints and the evolution of hormone-behavior interrelationships. Wingfield, J.C., Jacobs, J., Hillgarth, N. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  12. Developmental consequences of oxytocin. Carter, C.S. Physiol. Behav. (2003) [Pubmed]
  13. Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous vole. Pitkow, L.J., Sharer, C.A., Ren, X., Insel, T.R., Terwilliger, E.F., Young, L.J. J. Neurosci. (2001) [Pubmed]
  14. Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation. Insel, T.R., Winslow, J.T., Wang, Z., Young, L.J. Adv. Exp. Med. Biol. (1998) [Pubmed]
  15. Oxytocin and the molecular basis of monogamy. Insel, T.R., Winslow, J.T., Wang, Z.X., Young, L., Hulihan, T.J. Adv. Exp. Med. Biol. (1995) [Pubmed]
  16. Endogenous gonadal, LH and molt rhythms in tropical stonechats: effect of pair bond on period, amplitude, and pattern of circannual cycles. Gwinner, E., König, S., Zeman, M. J. Comp. Physiol. A (1995) [Pubmed]
  17. An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa. Gale, A.J., Pellequer, J.L. J. Thromb. Haemost. (2003) [Pubmed]
  18. Adrenocorticoid hormones and the development and expression of mammalian monogamy. Carter, C.S., DeVries, A.C., Taymans, S.E., Roberts, R.L., Williams, J.R., Chrousos, G.P. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
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