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Disease relevance of Arvicolinae


Psychiatry related information on Arvicolinae


High impact information on Arvicolinae

  • A role for central vasopressin in pair bonding in monogamous prairie voles [11].
  • Female prairie voles (Microtus ochrogaster) exposed to a single drop of male urine on the upper lip showed changes in concentrations of luteinizing hormone-releasing hormone (LHRH) and norepinephrine in olfactory bulb tissue; no such changes occurred in dopamine concentration [12].
  • 6-methoxybenzoxazolinone: a plant derivative that stimulates reproduction in Microtus montanus [13].
  • The associations between DEE/RMRt and site quality suggested that in February voles in poorer sites had higher energy demands, indicating that DEE was forced upwards, but in March the opposite was true, with higher demands in good sites, indicating that high expenditure was enabled [14].
  • Likewise, in adult male prairie voles, central (intracerebroventricular) injections of AVP can significantly increase intermale aggression, suggesting a role for AVP in the expression of postcopulatory aggression in adult male prairie voles [6].

Chemical compound and disease context of Arvicolinae


Biological context of Arvicolinae


Anatomical context of Arvicolinae

  • In the present study, we first used a highly specific affinity-purified antibody and a cRNA probe to generate a detailed mapping of BDNF immunoreactive (BDNF-ir) staining and mRNA labeling throughout the forebrain of female prairie voles [22].
  • Maternal and mating-induced aggression is associated with elevated citrulline immunoreactivity in the paraventricular nucleus in prairie voles [23].
  • Treatment with estradiol benzoate (EB) for 3 days increased the density of BrdU-labeled cells in the amygdala, particularly in the posterior cortical (pCorA) and medial (pMeA) nuclei, in meadow, but not prairie, voles [24].
  • In addition, 6-MBOA significantly increases the weight of the ovary and uterus in both peripubertal and mature voles [25].
  • After 6 h permanent subcutaneous infusion of BrdU in rodents (adult Microtus agrestis, pregnant NMRI-mice), cell nuclei which have undergone DNA synthesis during the BrdU treatment can be differentiated from the nuclei of other cycle stages by means of their altered staining behaviour after Giemsa [26].

Associations of Arvicolinae with chemical compounds

  • In female prairie voles, swim stress interferes with the development of social preferences and corticosterone treatments inhibit the formation of partner preferences, while adrenalectomized females form preferences more quickly than adrenally intact controls [27].
  • Similar to rats, therefore, postnatal estrogen influences some components of the extrahypothalamic AVP system in prairie voles, but this developing system appears to be insensitive to exogenous androgens, including aromatizable androgens [28].
  • In two experiments, voles were injected daily with melatonin from 20 to 80 or 80 to 140 d of age [29].
  • Adenylate cyclase (AC) in pineal particulate fractions from rabbit, rat, cow, and the vole Microtus montanus was stimulated by L-norepinephrine (NE) and L-isoproterenol (ISO) [30].
  • Unexpected effects of perinatal gonadal hormone manipulations on sexual differentiation of the extrahypothalamic arginine-vasopressin system in prairie voles [28].

Gene context of Arvicolinae

  • This study compared the effects of centrally administered oxytocin (OT) and arginine vasopressin (AVP) on partner preference formation and social contact in male and female prairie voles (Microtus ochrogaster) [31].
  • Species differences for OT receptor distribution were also observed in other microtine and murine species selected as monogamous or promiscuous [32].
  • Central administration of oxytocin facilitates and administration of an oxytocin antagonist inhibits partner preference formation in female prairie voles [33].
  • PNMT activity in these same voles was increased after 7 days and also remained elevated after 28 days of cold exposure [34].
  • A third series of experiments tested the hypothesis that brain OT influences affiliation by comparing prairie and montane voles, two closely related species with dichotomous systems of social organization [35].

Analytical, diagnostic and therapeutic context of Arvicolinae

  • Here we report cloning, sequence analysis, and detailed characterization of the Xist gene from four closely related species of common vole (field mouse), Microtus arvalis [36].
  • Sexually naive female prairie voles received a daily subcutaneous injection of 20 microg oxytocin or isotonic saline for 5 days before being placed with a sexually experienced male for 48 h [37].
  • By contrast, neither ovariectomy nor oestradiol affected odour preferences of short-photoperiod voles [38].
  • Microinjection of the D2 antagonist eticlopride into the NAcc (but not the prelimbic cortex) blocked the formation of a partner preference in mating voles, whereas the D2 agonist quinpirole facilitated formation of a partner preference in the absence of mating [39].
  • Laboratory bred bank voles of different age and reproductive status were bilaterally ovariectomized, treated with exogenous oestrogen or progesterone or both, and given an artificial decidual stimulus (crushing with artery forceps) [40].


  1. Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo. Piening, N., Nonno, R., Di Bari, M., Walter, S., Windl, O., Agrimi, U., Kretzschmar, H.A., Bertsch, U. J. Biol. Chem. (2006) [Pubmed]
  2. Estrogen and the induction of lordosis in female and male prairie voles (Microtus ochrogaster). Carter, C.S., Witt, D.M., Auksi, T., Casten, L. Hormones and behavior. (1987) [Pubmed]
  3. Effect of pharmacological blockade on cardiovascular responses to voluntary and forced diving in muskrats. Signore, P.E., Jones, D.R. J. Exp. Biol. (1995) [Pubmed]
  4. Melatonin increases tissue accumulation and toxicity of cadmium in the bank vole (Clethrionomys glareolus). Chwełatiuk, E., Włostowski, T., Krasowska, A., Bonda, E. Biometals (2005) [Pubmed]
  5. Effects of cold, short day and melatonin on thermogenesis, body weight and reproductive organs in Alaskan red-backed voles. Feist, D.D., Feist, C.F. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. (1986) [Pubmed]
  6. Developmental exposure to vasopressin increases aggression in adult prairie voles. Stribley, J.M., Carter, C.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster). Wang, Z., Ferris, C.F., De Vries, G.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles. Liu, Y., Wang, Z.X. Neuroscience (2003) [Pubmed]
  9. Dissociation between MK-801- and captivity-induced stereotypies in bank voles. Vandebroek, I., Berckmoes, V., Odberg, F.O. Psychopharmacology (Berl.) (1998) [Pubmed]
  10. Plasma testosterone levels are related to various aspects of locomotor activity in wild-caught male meadow voles (Microtus pennsylvanicus). Perrot-Sinal, T.S., Innes, D., Kavaliers, M., Ossenkopp, K.P. Physiol. Behav. (1998) [Pubmed]
  11. A role for central vasopressin in pair bonding in monogamous prairie voles. Winslow, J.T., Hastings, N., Carter, C.S., Harbaugh, C.R., Insel, T.R. Nature (1993) [Pubmed]
  12. Male vole urine changes luteinizing hormone-releasing hormone and norepinephrine in female olfactory bulb. Dluzen, D.E., Ramirez, V.D., Carter, C.S., Getz, L.L. Science (1981) [Pubmed]
  13. 6-methoxybenzoxazolinone: a plant derivative that stimulates reproduction in Microtus montanus. Sanders, E.H., Gardner, P.D., Berger, P.J., Negus, N.C. Science (1981) [Pubmed]
  14. Resting and daily energy expenditures of free-living field voles are positively correlated but reflect extrinsic rather than intrinsic effects. Speakman, J.R., Ergon, T., Cavanagh, R., Reid, K., Scantlebury, D.M., Lambin, X. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. Estrogen and progesterone interactions influencing sexual and social behavior in the brown lemming, Lemmus trimucronatus. Huck, U.W., Carter, C.S., Banks, E.M. Hormones and behavior. (1979) [Pubmed]
  16. Changes in albumin levels in blood and urine of Microtus montanus chronically infected with Trypanosoma brucei gambiense. Frommel, T.O., Seed, J.R., Sechelski, J. J. Parasitol. (1988) [Pubmed]
  17. Thyroid function and reproductive success in rodents exposed to perchlorate via food and water. Smith, P.N., Severt, S.A., Jackson, J.W., Anderson, T.A. Environ. Toxicol. Chem. (2006) [Pubmed]
  18. A translocated mitochondrial cytochrome b pseudogene in voles (Rodentia: Microtus). DeWoody, J.A., Chesser, R.K., Baker, R.J. J. Mol. Evol. (1999) [Pubmed]
  19. Reproductive status influences cell proliferation and cell survival in the dentate gyrus of adult female meadow voles: a possible regulatory role for estradiol. Ormerod, B.K., Galea, L.A. Neuroscience (2001) [Pubmed]
  20. Tyrosine hydroxylase-synthesizing cells in the hypothalamus of prairie voles (Microtus ochrogaster): sex differences in the anteroventral periventricular preoptic area and effects of adult gonadectomy or neonatal gonadal hormones. Lansing, S.W., Lonstein, J.S. J. Neurobiol. (2006) [Pubmed]
  21. Sex and seasonal differences in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles. Galea, L.A., McEwen, B.S. Neuroscience (1999) [Pubmed]
  22. Expression and estrogen regulation of brain-derived neurotrophic factor gene and protein in the forebrain of female prairie voles. Liu, Y., Fowler, C.D., Young, L.J., Yan, Q., Insel, T.R., Wang, Z. J. Comp. Neurol. (2001) [Pubmed]
  23. Maternal and mating-induced aggression is associated with elevated citrulline immunoreactivity in the paraventricular nucleus in prairie voles. Gammie, S.C., Nelson, R.J. J. Comp. Neurol. (2000) [Pubmed]
  24. Estrogen regulation of cell proliferation and distribution of estrogen receptor-alpha in the brains of adult female prairie and meadow voles. Fowler, C.D., Johnson, F., Wang, Z. J. Comp. Neurol. (2005) [Pubmed]
  25. The plant metabolite, 6-methoxybenzoxazolinone, stimulates an increase in secretion of follicle-stimulating hormone and size of reproductive organs in Microtus pinetorum. Schadler, M.H., Butterstein, G.M., Faulkner, B.J., Rice, S.C., Weisinger, L.A. Biol. Reprod. (1988) [Pubmed]
  26. Labelling of DNA and differential sister chromatid staining after BrdU treatment in vivo. Pera, F., Mattias, P. Chromosoma (1976) [Pubmed]
  27. The effects of stress on social preferences are sexually dimorphic in prairie voles. DeVries, A.C., DeVries, M.B., Taymans, S.E., Carter, C.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  28. Unexpected effects of perinatal gonadal hormone manipulations on sexual differentiation of the extrahypothalamic arginine-vasopressin system in prairie voles. Lonstein, J.S., Rood, B.D., De Vries, G.J. Endocrinology (2005) [Pubmed]
  29. Age, photoperiodic responses, and pineal function in meadow voles, Microtus pennsylvanicus. Donham, R.S., Horton, T.H., Rollag, M.D., Stetson, M.H. J. Pineal Res. (1989) [Pubmed]
  30. Cyclic nucleotide metabolism in pineal homogenates. Sweat, F.W., Carmack, C.F., Jewell, L.S. J. Pineal Res. (1988) [Pubmed]
  31. The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster). Cho, M.M., DeVries, A.C., Williams, J.R., Carter, C.S. Behav. Neurosci. (1999) [Pubmed]
  32. Molecular aspects of monogamy. Insel, T.R., Young, L., Wang, Z. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  33. Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation. Insel, T.R., Winslow, J.T., Wang, Z., Young, L.J. Adv. Exp. Med. Biol. (1998) [Pubmed]
  34. Catecholamine-synthesizing enzymes in adrenals of seasonally acclimatized voles. Feist, D.D., Feist, C.F. Journal of applied physiology: respiratory, environmental and exercise physiology. (1978) [Pubmed]
  35. Oxytocin--a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies. Insel, T.R. Psychoneuroendocrinology (1992) [Pubmed]
  36. Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence. Nesterova, T.B., Slobodyanyuk, S.Y., Elisaphenko, E.A., Shevchenko, A.I., Johnston, C., Pavlova, M.E., Rogozin, I.B., Kolesnikov, N.N., Brockdorff, N., Zakian, S.M. Genome Res. (2001) [Pubmed]
  37. Prior exposure To oxytocin mimics the effects Of social contact and facilitates sexual behaviour In females. Cushing, B.S., Carter, C.S. J. Neuroendocrinol. (1999) [Pubmed]
  38. Seasonal control of odour preferences of meadow voles (Microtus pennsylvanicus) by photoperiod and ovarian hormones. Ferkin, M.H., Zucker, I. J. Reprod. Fertil. (1991) [Pubmed]
  39. Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster). Gingrich, B., Liu, Y., Cascio, C., Wang, Z., Insel, T.R. Behav. Neurosci. (2000) [Pubmed]
  40. Hormonal requirements and the influence of age on the decidual cell reaction in the bank vole (Clethrionomys glareolus). Nerquaye-Tetteh, J.O., Clarke, J.R. J. Reprod. Fertil. (1987) [Pubmed]
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