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MeSH Review

Only Child

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Disease relevance of Only Child


Psychiatry related information on Only Child

  • Variables consistently unrelated to TV/video viewing were sex, other indicators of socio-economic status, body fatness, cholesterol levels, aerobic fitness, strength, other indicators of fitness, self-perceptions, emotional support, physical activity, other diet variables, and being an only child [2].

High impact information on Only Child

  • Among children only receiving one dose of measles vaccine at age 9 months, 100,000 IU vitamin A increased antibody concentrations, especially for boys [3].
  • The only child of the propositus, a daughter, showed a similar relative resistance, confirming that this family is the third to be reported with hereditary resistance to warfarin [4].
  • METHODS: In 198 children (with two kidneys, single kidney, or renal transplant) and 116 adults (single kidney and transplanted), we measured inulin clearance and creatinine clearance and calculated Cockcroft-Gault, MDRD and, in children only, Schwartz [5].
  • METHODS: This study was undertaken at a tertiary children's hospital, The Children's Hospital at Westmead, The Royal Alexandra Hospital for Children, Westmead, Sydney, Australia. Only children with severe acute asthma as determined by the National Asthma Campaign guidelines criteria and pulmonary index were included [6].
  • In the French MDH 90 trial, 15% of children failed to reach ECR after four cycles; in these children only, anthracyclines plus alkylating agents were given and the dose of radiotherapy increased, improving the results observed in the previous trial [7].

Associations of Only Child with chemical compounds

  • These findings raise questions about the current practice of screening only children with a family history of cardiovascular disease to identify those with elevated total cholesterol and LDL-C levels [8].
  • Twenty children only received an initial loading dose of 3 mg/kg intravenous propofol [9].
  • A 14-year-old boy, an only child, with the phenotypical dysmorphic features of the King-Denborough Syndrome developed a severe hyperthermic episode during anesthesia which responded to the administration of sodium dantrolene [10].
  • EEG spikes were confirmed in one child only; the corresponding laudanosine Cmax was 720 ng ml(-1) [11].
  • The diagnosis was supported by technetium micro aggregate lung perfusion scans in three of the children and in the fourth, the only child to die, by autopsy [12].

Gene context of Only Child

  • Interestingly, the only child infected with a multitropic virus carried a defective CCR5 allele [13].
  • Nine (2.2 %) Kenyan and 12 (6.6 %) of the Sudanese children only were carriers of variants within the coding sequence of the GJB2 gene [14].
  • Urinary IGFBP-2, IGFBP-3 and ALS were detectable in the SDNS children only [15].
  • CONCLUSION: Although only children with ADHD are characterized primarily by "attention deficit," sustained attention deficit is common to a certain extent to all children with psychiatric disorders [16].
  • CONCLUSIONS: Asthma is related to atopy in pre-selected children only from the age of 7 years [17].

Analytical, diagnostic and therapeutic context of Only Child


  1. Cholesterol screening by primary care pediatricians: a study of attitudes and practices in the Minneapolis-St Paul metropolitan area. Arneson, T., Luepker, R., Pirie, P., Sinaiko, A. Pediatrics (1992) [Pubmed]
  2. Couch kids: correlates of television viewing among youth. Gorely, T., Marshall, S.J., Biddle, S.J. International journal of behavioral medicine. (2004) [Pubmed]
  3. Randomised trial of effect of vitamin A supplementation on antibody response to measles vaccine in Guinea-Bissau, west Africa. Benn, C.S., Aaby, P., Balé, C., Olsen, J., Michaelsen, K.F., George, E., Whittle, H. Lancet (1997) [Pubmed]
  4. Hereditary warfarin resistance. Investigation of a rare phenomenon. Alving, B.M., Strickler, M.P., Knight, R.D., Barr, C.F., Berenberg, J.L., Peck, C.C. Arch. Intern. Med. (1985) [Pubmed]
  5. Predicting GFR in children and adults: a comparison of the Cockcroft-Gault, Schwartz, and modification of diet in renal disease formulas. Pierrat, A., Gravier, E., Saunders, C., Caira, M.V., Aït-Djafer, Z., Legras, B., Mallié, J.P. Kidney Int. (2003) [Pubmed]
  6. Randomized, double-blind, placebo-controlled trial of intravenous salbutamol and nebulized ipratropium bromide in early management of severe acute asthma in children presenting to an emergency department. Browne, G.J., Trieu, L., Van Asperen, P. Crit. Care Med. (2002) [Pubmed]
  7. Early response to chemotherapy: a surrogate for final outcome of Hodgkin's disease patients that should influence initial treatment length and intensity? Carde, P., Koscielny, S., Franklin, J., Axdorph, U., Raemaekers, J., Diehl, V., Aleman, B., Brosteanu, O., Hasenclever, D., Oberlin, O., Bonvin, N., Björkholm, M. Ann. Oncol. (2002) [Pubmed]
  8. Parental history of cardiovascular disease as an indication for screening for lipoprotein abnormalities in children. Dennison, B.A., Kikuchi, D.A., Srinivasan, S.R., Webber, L.S., Berenson, G.S. J. Pediatr. (1989) [Pubmed]
  9. The pharmacokinetics of propofol in children using three different data analysis approaches. Kataria, B.K., Ved, S.A., Nicodemus, H.F., Hoy, G.R., Lea, D., Dubois, M.Y., Mandema, J.W., Shafer, S.L. Anesthesiology (1994) [Pubmed]
  10. Dominantly inherited malignant hyperthermia (MH) in the King-Denborough syndrome. Isaacs, H., Badenhorst, M.E. Muscle Nerve (1992) [Pubmed]
  11. Pharmacokinetics and dynamics of atracurium infusions after paediatric orthotopic liver transplantation. Chow, B., Bowden, M.I., Ho, E., Weatherley, B.C., Bion, J.F. British journal of anaesthesia. (2000) [Pubmed]
  12. Pulmonary thromboembolism in children. Matthew, D.J., Levin, M. Intensive care medicine. (1986) [Pubmed]
  13. HIV type 1 chemokine receptor usage in mother-to-child transmission. Salvatori, F., Scarlatti, G. AIDS Res. Hum. Retroviruses (2001) [Pubmed]
  14. Low frequency of deafness-associated GJB2 variants in Kenya and Sudan and novel GJB2 variants. Gasmelseed, N.M., Schmidt, M., Magzoub, M.M., Macharia, M., Elmustafa, O.M., Ototo, B., Winkler, E., Ruge, G., Horstmann, R.D., Meyer, C.G. Hum. Mutat. (2004) [Pubmed]
  15. IGFs and IGF-binding proteins in short children with steroid-dependent nephrotic syndrome on chronic glucocorticoids: changes with 1 year exogenous GH. Zhou, X., Loke, K.Y., Pillai, C.C., How, H.K., Yap, H.K., Lee, K.O. Eur. J. Endocrinol. (2001) [Pubmed]
  16. Visual sustained attention in a child psychiatric population. Swaab-Barneveld, H., de Sonneville, L., Cohen-Kettenis, P., Gielen, A., Buitelaar, J., Van Engeland, H. Journal of the American Academy of Child and Adolescent Psychiatry. (2000) [Pubmed]
  17. Atopy and house dust mite sensitization as risk factors for asthma in children. Miraglia Del Giudice, M., Pedullà, M., Piacentini, G.L., Capristo, C., Brunese, F.P., Decimo, F., Maiello, N., Capristo, A.F. Allergy (2002) [Pubmed]
  18. Dual-probe pH monitoring for the assessment of gastroesophageal reflux in the course of chronic hoarseness in children. Kalach, N., Gumpert, L., Contencin, P., Dupont, C. Turk. J. Pediatr. (2000) [Pubmed]
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