Disease relevance of Ambrosia

• Ragweed (Ambrosia artemisiifolia), the major cause of late summer hay fever (allergic rhinitis) in the United States and Canada, is clinically the most important source of the seasonal aeroallergens [1].
• An epidemiological assessment of Ambrosia maritima on the transmission of schistosomiasis in the Egyptian Nile Delta [2].

High impact information on Ambrosia

• At WOL C(4) abundance was negatively correlated with aragonite/calcite, suggesting that severe moisture deficits suppressed C(4) plants in favor of weedy C(3) plants (e.g., Ambrosia) [3].
• The structural features of Bet v 1 are highly similar to those found in the Ambrosia allergen Amb t V [4].
• T cell epitope mapping of ragweed pollen allergen Ambrosia artemisiifolia (Amb a 5) and Ambrosia trifida (Amb t 5) and the role of free sulfhydryl groups in T cell recognition [5].
• Antigens of Ambrosia elatior (short ragweed) pollen. III. Crossed radioimmunoelectrophoresis of ragweed-allergic patients' sera with special attention to quantification of IgE responses [6].
• METHODS: Reactive oxygen species (ROS) generation by hydrated Ambrosia artemisiifolia pollen (short ragweed pollen; RWP) grains was determined by using 2'-7'-dihydro-dichlorofluorescein diacetate, nitroblue tetrazolium reduction, and Amplex Red assay [7].

Biological context of Ambrosia

• The nucleotide sequence of a cDNA (designated IPC1/5) encoding a cystatin (Cyt) proteinase-inhibitor homologue from short ragweed (Ambrosia artemisiifolia) pollen was determined and compared to other plant and animal Cyt [8].
• We investigated the molecular basis for the striking association between HLA-DR2,Dw2 and human immune responsiveness to the Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a V by sequencing the second exons of the DRB and DQB1 genes of 17 selected ragweed-allergic Caucasoid subjects [9].

Associations of Ambrosia with chemical compounds

• Cloning and expression of immunologically active recombinant Amb a V allergen of short ragweed (Ambrosia artemisiifolia) pollen [10].
• Five per cent (w/v) extracts of defatted Ambrosia elatior pollen were prepared in bicarbonate-buffered saline (Coca's extract) and Coca's extract with 50% glycerol (Gly-Coca's extract) [11].
• Purification and characterization of an arginine-specific peptidase from ragweed (Ambrosia artemisiifolia) pollen [12].
• This study focuses on pollen from Betula, the Poaceae, Ambrosia, Parietaria and Olea, but also examines the implications of climatic change for other aeroallergens, including those from various crops such as Brassica species (oil-seed rape) and Helianthemum (sunflowers) [13].
• It revealed activity in a methanol extract from the common ragweed Ambrosia artemisiifolia [14].

Gene context of Ambrosia

• Sequence of the proteinase-inhibitor cystatin homologue from the pollen of Ambrosia artemisiifolia (short ragweed) [8].
• We studied the pharmacologic regulation of IL-13 expression by cyclic nucleotide phosphodiesterase (PDE) inhibitors in a panel of Amb a 1 (a major allergen of short ragweed, Ambrosia artemisiifolia)-specific T cell clones derived from a ragweed allergic, asthmatic subject [15].
• Prominent airborne pollen taxa were Acer, Quercus, Betula, Pinus, Cupressaceae, Poaceae, Ambrosia, and Rumex [16].
• Specific immune responsiveness to the Amb a V allergen (from Ambrosia artemisiifolia, short ragweed pollen) is significantly associated with the Class II specificities, human leucocyte antigen (HLA)-DR2 and Dw2 determined by serological and MLR typing ("DR2.2") [17].
• Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy [18].

Analytical, diagnostic and therapeutic context of Ambrosia

• Two chromatographic forms (A and B) of the rapidly released short ragweed (Ambrosia elatior) pollen allergen Ra6 were isolated to antigenic ultrapurity by a combination of membrane filtration and ion exchange and gel filtration chromatography [19].
• Parthenium hysterophorus (PH) is a ubiquitous weed found in the U.S. Gulf Coast. In this study, 582 sera, contributed by 22 physicians from 18 Gulf Coast cities, were examined by ELISA for IgE directed against determinants in an aqueous extract of PH pollen, and these were compared to an extract of western ragweed (Ambrosia psilostachya [AP]) [20].

References