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MeSH Review


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Disease relevance of Cornus


High impact information on Cornus

  • Schmit, Populus sieboldii Miq., Betula platyphylla Sukat. var japonica Hara, Betula pubescens Ehrh., and red osier dogwood (Cornus sericea), in which XRPCs have been reported to respond by extracellular freezing [2].
  • Although a significant loss of hippocampal Cornus Ammonis CA1, CA3 and CA4 neurons was observed at 3 weeks post-TMT, the elevation in the level of hydroxyl radicals, MDA, and protein carbonyl had returned to near-control levels at that time [3].
  • In serotonin-lesioned rats, the significant increases in full-length BDNF, exon I and exon II mRNA levels were sustained without alteration (with the exception of exon IV in the cornus ammonis subregion 4, CA4) [4].
  • Our data, added to the previously demonstrated high affinity of eltoprazine for 5HT1 sites, suggest that in the hippocampal cornus ammoni-1 area eltoprazine acts as a partial 5HT1 agonist with a relatively low intrinsic activity but a considerable potency to suppress hyperpolarizing responses to 5HT [5].
  • During May 1994, when the demand for sucrose was greatest, dogwood accumulated small amounts of glucose, quinic acid and Mg2+, offsetting a decline in nitrate concentration [6].

Anatomical context of Cornus


Associations of Cornus with chemical compounds

  • Among solutes, glucose constituted the largest accumulation in dogwood in the dry treatment in August 1995, followed by fructose and sucrose [6].
  • As the mild drought continued and tree growth slowed, there was a significant accumulation of sucrose in dogwood in the dry treatment in June, and a trend toward increased K+ [6].
  • Separation of gallic acid from Cornus officinalis Sieb. et Zucc by high-speed counter-current chromatography [8].
  • Mercuric chloride (HgCl(2)) was also used to characterize the water flow responses and respiration of dogwood roots [9].
  • The short-term effects of sodium azide (NaN(3)) on water flow in red-osier dogwood (Cornus stolonifera Michx.) seedlings were examined in excised roots at a constant pressure of 0.3 MPa [9].

Gene context of Cornus

  • The present study was conducted to determine whether iridoid total glycoside from Cornus officinalis was effective in regulating expression of transforming growth factor beta 1 (TGF-beta1) and preventing overdeposition of extracellular matrix (ECM) in a diabetes state [10].
  • Seasonal regulation of a 24-kDa protein from red-osier dogwood (Cornus sericea) xylem [11].
  • The germination of seeds was initially delayed by 15% FT in dogwood (Cornus stolonifera Michx) and jack pine (Pinus banksiana Lamb) but not in white spruce [Picea glauca (Moench) Voss] [12].
  • The water extracts of Cornus officinalis Sieb. et Zuce against hepatocellular carcinoma (HCC) was studied for its chemopreventive potential [13].
  • Weekly collections of fresh male and female dogwood borer pupal exuviae from April until October in 2002 and 2003 suggested that traps baited with Scenturion lures significantly underestimated the size of populations in commercial apple orchards [14].

Analytical, diagnostic and therapeutic context of Cornus


  1. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). Jayaprakasam, B., Olson, L.K., Schutzki, R.E., Tai, M.H., Nair, M.G. J. Agric. Food Chem. (2006) [Pubmed]
  2. Xylem ray parenchyma cells in boreal hardwood species respond to subfreezing temperatures by deep supercooling that is accompanied by incomplete desiccation. Kuroda, K., Kasuga, J., Arakawa, K., Fujikawa, S. Plant Physiol. (2003) [Pubmed]
  3. Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis. Shin, E.J., Suh, S.K., Lim, Y.K., Jhoo, W.K., Hjelle, O.P., Ottersen, O.P., Shin, C.Y., Ko, K.H., Kim, W.K., Kim, D.S., Chun, W., Ali, S., Kim, H.C. Neuroscience (2005) [Pubmed]
  4. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Garcia, C., Chen, M.J., Garza, A.A., Cotman, C.W., Russo-Neustadt, A. Neuroscience (2003) [Pubmed]
  5. Eltoprazine suppresses hyperpolarizing responses to serotonin in rat hippocampus. Joëls, M., Pennartz, C.M., Sijbesma, H., Schipper, J. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  6. Solute accumulation of chestnut oak and dogwood leaves in response to throughfall manipulation of an upland oak forest. Gebre, G.M., Tschaplinski, T.J. Tree Physiol. (2002) [Pubmed]
  7. Morroniside protects cultured human umbilical vein endothelial cells from damage by high ambient glucose. Xu, H.Q., Hao, H.P., Zhang, X., Pan, Y. Acta Pharmacol. Sin. (2004) [Pubmed]
  8. Separation of gallic acid from Cornus officinalis Sieb. et Zucc by high-speed counter-current chromatography. Tian, G., Zhang, T., Yang, F., Ito, Y. Journal of chromatography. A. (2000) [Pubmed]
  9. Metabolic inhibition of root water flow in red-osier dogwood (Cornus stolonifera) seedlings. Kamaluddin, M., Zwiazek, J.J. J. Exp. Bot. (2001) [Pubmed]
  10. Effects of iridoid total glycoside from Cornus officinalis on prevention of glomerular overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model. Xu, H.Q., Hao, H.P. Biol. Pharm. Bull. (2004) [Pubmed]
  11. Seasonal regulation of a 24-kDa protein from red-osier dogwood (Cornus sericea) xylem. Sarnighausen, E., Karlson, D., Ashworth, E. Tree Physiol. (2002) [Pubmed]
  12. Germination, growth and gas exchange of selected boreal forest seedlings in soil containing oil sands tailings. Renault, S., Zwiazek, J.J., Fung, M., Tuttle, S. Environ. Pollut. (2000) [Pubmed]
  13. Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro. Chang, J.S., Chiang, L.C., Hsu, F.F., Lin, C.C. Am. J. Chin. Med. (2004) [Pubmed]
  14. Discrimination by male dogwood borer, Synanthedon scitula (Lepidoptera: Sesiidae), among traps baited with commercially available pheromone lures. Bergh, J.C., Leskey, T.C., Zhang, A. J. Econ. Entomol. (2004) [Pubmed]
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