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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genetic Research

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Disease relevance of Genetic Research


Psychiatry related information on Genetic Research


High impact information on Genetic Research

  • AAAS conference explores ethical aspects of large pedigree genetic research [6].
  • In recent years a great deal of biochemical and genetic research has focused on the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II [7].
  • INTRODUCTION: Past research has shown substantial genetic influence on bone quality, and the impact of reduced bone mass on our aging population has heightened the interest in skeletal genetic research [8].
  • Evidence Acquisition: Evidence from experimental, clinical, and genetic research supporting the hypothesis for the fetal origins of PCOS has been analyzed [9].
  • Genetic research into the inherited multiple form, hereditary multiple exostoses, has revealed a new family of tumour suppressor genes denoted EXT [10].

Biological context of Genetic Research


Anatomical context of Genetic Research

  • Several recent reviews have provided a comprehensive discussion of biochemical, cellular, and genetic research on E2A function in lymphocyte development (1,2) [13].

Associations of Genetic Research with chemical compounds


Gene context of Genetic Research

  • CONCLUSION: Although further genetic research should be conducted, it is suggested that the CTR genetic test could become a useful tool in the planning of treatment before implant surgery and lead to more predictable implant treatment [19].
  • Biochemical markers and genetic research of ADHD [20].
  • The gene involved has been characterized only for two of such loci, IDDM1 and IDDM2, while in the other cases the presence of some susceptibility genes can be envisaged and their identification represents the goal of genetic research in coming years [21].
  • The determination of COMT in hair root cells offers a further application of this source in genetic research, as in the study of a correlation between COMT activity and various endogenous psychiatric disorders [22].
  • The use of persons who become alcoholic despite having a well-defined negative risk for alcoholism (inactive aldehyde dehydrogenase-2 or ALDH2) is advantageous in genetic research because of this population's reduced heterogeneity and possible genetic factors conferring susceptibility to alcohol dependence [23].


  1. Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group. Fink, J.K., Heiman-Patterson, T., Bird, T., Cambi, F., Dubé, M.P., Figlewicz, D.A., Fink, J.K., Haines, J.L., Heiman-Patterson, T., Hentati, A., Pericak-Vance, M.A., Raskind, W., Rouleau, G.A., Siddique, T. Neurology (1996) [Pubmed]
  2. Molecular biology as a tool for genetic research in hypertension: application to the renin gene. Soubrier, F., Houot, A.M., Jeunemaitre, X., Plouin, P.F., Corvol, P. J. Cardiovasc. Pharmacol. (1988) [Pubmed]
  3. Evaluation of newborns with skeletal dysplasias. Macpherson, R.I., Pai, G.S. Indian journal of pediatrics. (2000) [Pubmed]
  4. Pharmacogenetics of lithium response in bipolar disorder. Alda, M. Journal of psychiatry & neuroscience : JPN. (1999) [Pubmed]
  5. Individual differences in sensitivity to nicotine: implications for genetic research on nicotine dependence. Pomerleau, O.F. Behav. Genet. (1995) [Pubmed]
  6. AAAS conference explores ethical aspects of large pedigree genetic research. Glass, R.M. JAMA (1992) [Pubmed]
  7. Evolution of the RNA polymerase II C-terminal domain. Stiller, J.W., Hall, B.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. Lang, D.H., Sharkey, N.A., Mack, H.A., Vogler, G.P., Vandenbergh, D.J., Blizard, D.A., Stout, J.T., McClearn, G.E. J. Bone Miner. Res. (2005) [Pubmed]
  9. Fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies. Xita, N., Tsatsoulis, A. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  10. The neoplastic pathogenesis of solitary and multiple osteochondromas. Porter, D.E., Simpson, A.H. J. Pathol. (1999) [Pubmed]
  11. Myotonic muscular dystrophy. Alberts, M.J., Roses, A.D. Neurologic clinics. (1989) [Pubmed]
  12. Collaborative design for automated DNA storage that allows for rapid, accurate, large-scale studies. Mahan, S., Ardlie, K.G., Krenitsky, K.F., Walsh, G., Clough, G. Assay and drug development technologies. (2004) [Pubmed]
  13. A genetic investigation of E2A function in lymphocyte development. Hanrahan, J., Pan, L., Greenbaum, S., Bradney, C., Hjelmeland, M., Dai, M., Zhuang, Y. Immunol. Res. (2000) [Pubmed]
  14. Defining nicotine dependence for genetic research: evidence from Australian twins. Lessov, C.N., Martin, N.G., Statham, D.J., Todorov, A.A., Slutske, W.S., Bucholz, K.K., Heath, A.C., Madden, P.A. Psychological medicine. (2004) [Pubmed]
  15. Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Neumeister, A., Young, T., Stastny, J. Psychopharmacology (Berl.) (2004) [Pubmed]
  16. Genetics of proteinases of lactic acid bacteria. Kok, J., Venema, G. Biochimie (1988) [Pubmed]
  17. No association found between 158 Val/Met polymorphism of the COMT gene and schizophrenia with minor physical anomalies. Joo, E.J., Jeong, S.H., Ahn, Y.M., Lee, K.Y., Chang Yoon, S., Kim, E.J., Kim, S.U., Cho, S.C., Sik Kim, Y. Psychiatry research. (2005) [Pubmed]
  18. No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. Patkar, A.A., Berrettini, W.H., Hoehe, M., Hill, K.P., Gottheil, E., Thornton, C.C., Weinstein, S.P. Psychiatr. Genet. (2002) [Pubmed]
  19. Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants. Nosaka, Y., Tachi, Y., Shimpuku, H., Kawamura, T., Ohura, K. The International journal of oral & maxillofacial implants. (2002) [Pubmed]
  20. Biochemical markers and genetic research of ADHD. Paclt, I., Koudelová, J., Krepelová, A., Uhlíková, P., Gazdíková, M., Bauer, P. Neuro Endocrinol. Lett. (2005) [Pubmed]
  21. Dissecting the genetics of type 1 diabetes: relevance for familial clustering and differences in incidence. Buzzetti, R., Quattrocchi, C.C., Nisticò, L. Diabetes/metabolism reviews. (1998) [Pubmed]
  22. A radioenzymatic assay of catechol-O-methyltransferase in hair root cells: comparison with erythrocyte activity. Hoo, J.J., Strohmeyer, T., Beckermann, W.J., Agarwal, D.P., Goedde, H.W. Hum. Genet. (1981) [Pubmed]
  23. Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. Hasegawa, Y., Higuchi, S., Matsushita, S., Miyaoka, H. Journal of neural transmission (Vienna, Austria : 1996) (2002) [Pubmed]
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