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MeSH Review


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Disease relevance of Argemone


High impact information on Argemone

  • Argemone oil/alkaloid showed a Type II binding spectra with hepatic cytochrome P-450 (P-450) protein, thereby causing loss of P-450 content and an impairment of phase I and phase II enzymes [2].
  • Swiss albino mice were intraperitoneally administered 0.5, 1.0, 2.0 and 4.0 ml/kg body wt. of argemone oil to analyze chromosome aberrations and micronucleus test, while 0.25, 0.5, 1.0 and 2.0 ml/kg body wt. were given for alkaline comet assay [3].
  • A prior temperature shock treatment to the larvae was enough to protect the larvae from argemone oil-induced tissue damage as evidenced by little or no trypan blue staining [4].
  • These results suggest that primarily 1O2 and OH. radicals are involved in argemone oil-induced hepatic microsomal lipid peroxidation, and that bio-antioxidant vitamins including riboflavin, beta-carotene and alpha-tocopherol may prove useful in reducing argemone oil-induced hepatotoxicity [5].
  • Also, multiple treatment of argemone oil caused a depletion of endogenous hepatic glutathione (GSH) content (72%) with a concomitant increase in lipid peroxidation (177%) and decrease in glutathione-S-transferase (GST) activity (30%) [6].

Anatomical context of Argemone


Associations of Argemone with chemical compounds

  • Hepatic alkaline phosphatase, alanine transaminase and aspartate transaminase activities were inhibited by 30, 29 and 29% after 30 days of argemone intake along with concomitant enhancement in serum by 27, 29 and 66%, respectively [8].
  • Mustard oil, which was used for cooking, was found to be contaminated with oil of Argemone mexicana seeds [9].
  • The effects of sub-lethal treatments (20 and 60% of 24-h LC(50)) with plant-derived molluscicides Annona squamosa, acetogenins, Argemone mexicana seed and protopine, in combination (1 + 5) with MGK-264 (ENT 8184) or piperonyl butoxide on the reproduction of Lymnaea acuminata has been studied [10].

Gene context of Argemone

  • Animals sacrificed 72 h after a single intraparenteral dose of argemone oil exhibited a significant loss of hepatic cytochrome P-450 (35%) and cytochrome b5 (34%) contents and inhibition of aminopyrine-N-demethylase (APD), aryl hydrocarbon hydroxylase (AHH) and ethoxycoumarin-O-deethylase (ECD) activities (21-39%) [6].
  • Inhibition of human pregnancy plasma diamine oxidase with alkaloids of Argemone mexicana--berberine and sanguinarine [11].


  1. Argemone oil induced cellular damage in the reproductive tissues of transgenic Drosophila melanogaster: protective role of 70 kDa heat shock protein. Mukhopadhyay, I., Saxena, D.K., Bajpai, V.K., Chowdhuri, D.K. J. Biochem. Mol. Toxicol. (2003) [Pubmed]
  2. Clinicoepidemiological, toxicological, and safety evaluation studies on argemone oil. Das, M., Khanna, S.K. Crit. Rev. Toxicol. (1997) [Pubmed]
  3. Unequivocal evidence of genotoxic potential of argemone oil in mice. Ansari, K.M., Chauhan, L.K., Dhawan, A., Khanna, S.K., Das, M. Int. J. Cancer (2004) [Pubmed]
  4. Toxicity of argemone oil: effect on hsp70 expression and tissue damage in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9. Mukhopadhyay, I., Nazir, A., Mahmood, K., Saxena, D.K., Das, M., Khanna, S.K., Chowdhuri, D.K. Cell Biol. Toxicol. (2002) [Pubmed]
  5. Role of antioxidants and scavengers on argemone oil-induced toxicity in rats. Upreti, K.K., Das, M., Khanna, S.K. Arch. Environ. Contam. Toxicol. (1991) [Pubmed]
  6. Biochemical toxicology of argemone oil. I. Effect on hepatic cytochrome P-450 and xenobiotic metabolizing enzymes. Upreti, K.K., Das, M., Khanna, S.K. Journal of applied toxicology : JAT. (1991) [Pubmed]
  7. Biochemical toxicology of argemone alkaloids. III. Effect on lipid peroxidation in different subcellular fractions of the liver. Upreti, K.K., Das, M., Khanna, S.K. Toxicol. Lett. (1988) [Pubmed]
  8. Biochemical toxicology of argemone oil. IV. Short-term oral feeding response in rats. Upreti, K.K., Das, M., Kumar, A., Singh, G.B., Khanna, S.K. Toxicology (1989) [Pubmed]
  9. Epidemic dropsy in the eastern region of Nepal. Singh, R., Faridi, M.M., Singh, K., Siddiqui, R., Bhatt, N., Karna, S. J. Trop. Pediatr. (1999) [Pubmed]
  10. Effect of binary combination of some plant-derived molluscicides with MGK-264 or piperonyl butoxide on the reproduction of the snail Lymnaea acuminata. Singh, P., Singh, V.K., Singh, D.K. Pest Manag. Sci. (2005) [Pubmed]
  11. Inhibition of human pregnancy plasma diamine oxidase with alkaloids of Argemone mexicana--berberine and sanguinarine. Vaidya, A.B., Rajagopalan, T.G., Kale, A.G., Levine, R.J. Journal of postgraduate medicine. (1980) [Pubmed]
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