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MeSH Review


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Disease relevance of Adamantinoma


High impact information on Adamantinoma


Biological context of Adamantinoma


Anatomical context of Adamantinoma

  • To gain more insight into the differentiation characteristics of the epithelial cells of the adamantinoma of the long bones, we studied the specific keratin immunoreactivity pattern using monoclonal antibodies on 34 primary, recurrent, or metastatic specimens of 22 patients [6].

Gene context of Adamantinoma

  • Twenty-four cases of adamantinoma and 24 cases of osteofibrous dysplasia of the long bones were studied to evaluate the expression and distribution of cytokeratin (CK) subtypes in relation to histogenesis and differentiation [7].
  • In 71% of adamantinomas, vimentin showed strong immunoreactivity in the tumour cells of nests and tubules [7].
  • In osteofibrous dysplasia the epithelial-like component was much smaller than in adamantinoma and was present in scattered islands composed of a few cell positive for CKAE1/AE3 and CK19 and negative for other keratins [7].
  • CD99 positive adamantinoma of the ulna with ipsilateral discrete osteofibrous dysplasia [8].
  • Distribution of extracellular matrix components in adamantinoma of long bones suggests fibrous-to-epithelial transformation [9].


  1. Telomerase activity in skeletal sarcomas. Aue, G., Muralidhar, B., Schwartz, H.S., Butler, M.G. Ann. Surg. Oncol. (1998) [Pubmed]
  2. DNA aberrations in the epithelial cell component of adamantinoma of long bones. Hazelbag, H.M., Fleuren, G.J., Cornelisse, C.J., van den Broek, L.J., Taminiau, A.H., Hogendoorn, P.C. Am. J. Pathol. (1995) [Pubmed]
  3. Expression of growth factors and their receptors in adamantinoma of long bones and the implication for its histogenesis. Bovée, J.V., van den Broek, L.J., de Boer, W.I., Hogendoorn, P.C. J. Pathol. (1998) [Pubmed]
  4. Osteofibrous dysplasia and adamantinoma: correlation of proto-oncogene product and matrix protein expression. Maki, M., Athanasou, N. Hum. Pathol. (2004) [Pubmed]
  5. Expression of cytokeratin 1, 5, 14, 19 and transforming growth factors-beta1, beta2, beta3 in osteofibrous dysplasia and adamantinoma: A possible association of transforming growth factor-beta with basal cell phenotype promotion. Maki, M., Saitoh, K., Kaneko, Y., Fukayama, M., Morohoshi, T. Pathol. Int. (2000) [Pubmed]
  6. Adamantinoma of the long bones: keratin subclass immunoreactivity pattern with reference to its histogenesis. Hazelbag, H.M., Fleuren, G.J., vd Broek, L.J., Taminiau, A.H., Hogendoorn, P.C. Am. J. Surg. Pathol. (1993) [Pubmed]
  7. Cytokeratin expression and distribution in adamantinoma of the long bones and osteofibrous dysplasia of tibia and fibula. An immunohistochemical study correlated to histogenesis. Benassi, M.S., Campanacci, L., Gamberi, G., Ferrari, C., Picci, P., Sangiorgi, L., Campanacci, M. Histopathology (1994) [Pubmed]
  8. CD99 positive adamantinoma of the ulna with ipsilateral discrete osteofibrous dysplasia. Sherman, G.M., Damron, T.A., Yang, Y. Clin. Orthop. Relat. Res. (2003) [Pubmed]
  9. Distribution of extracellular matrix components in adamantinoma of long bones suggests fibrous-to-epithelial transformation. Hazelbag, H.M., Van den Broek, L.J., Fleuren, G.J., Taminiau, A.H., Hogendoorn, P.C. Hum. Pathol. (1997) [Pubmed]
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