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MeSH Review

Image Cytometry

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Disease relevance of Image Cytometry


High impact information on Image Cytometry


Chemical compound and disease context of Image Cytometry


Biological context of Image Cytometry

  • To investigate possible cellular correlates of polyploidization, the protein content and nucleolar activity per cell and per genome were examined by image cytometry in 21 mammalian species, differing in the degree of heart polyploidization and heart index [12].
  • The Ki-67 labeling index was 36% and the DNA content of the tumor cells, which was examined by image cytometry, demonstrated diploidy (DNA index = 0.95) [13].
  • Cell proliferation was measured by immunohistochemistry using PCNA labeling index (LI) and by Tv image cytometry evaluating 12 morpho- and densitometric parameters of each nuclei and 6 additional parameters of each smear [14].

Associations of Image Cytometry with chemical compounds


Gene context of Image Cytometry

  • Immunoperoxidase staining was carried out for EGF and EGFR and the density of the staining quantified using image cytometry by an operator unaware of the diagnosis [20].
  • Total vessel count (TVC), microvessel count (MVC) and mean vessel diameter (VD) in the CD34-stained tissues were measured in five hot spot areas at x 200 magnification by image cytometry [21].
  • Protein expression of adhesion molecules ICAM-1 and E-selectin of HUVEC were evaluated via immunocytochemical techniques combined with image cytometry [22].
  • Preneoplastic oral lesions: the clinical value of image cytometry DNA analysis, p53 and p21/WAF1 expression [23].
  • OBJECTIVE: To evaluate image cytometry for detecting estrogen (ER) and progesterone receptors (PR) in breast lumps quantitatively [24].

Analytical, diagnostic and therapeutic context of Image Cytometry


  1. Nuclear DNA distribution pattern of the parenchymal cells in adenocarcinomas of the pancreas and in chronic pancreatitis. A study of archival specimens using both image and flow cytometry. Weger, A.R., Falkmer, U.G., Schwab, G., Glaser, K., Kemmler, G., Bodner, E., Auer, G.U., Mikuz, G. Gastroenterology (1990) [Pubmed]
  2. Aberrant dipeptidyl peptidase IV (DPP IV/CD26) expression in human hepatocellular carcinoma. Stecca, B.A., Nardo, B., Chieco, P., Mazziotti, A., Bolondi, L., Cavallari, A. J. Hepatol. (1997) [Pubmed]
  3. DNA image cytometry and the expression of proliferative markers (proliferating cell nuclear antigen and Ki67) in non-Hodgkin's lymphomas. Czader, M., Porwit, A., Tani, E., Ost, A., Mazur, J., Auer, G. Mod. Pathol. (1995) [Pubmed]
  4. Response to chemotherapy (irinotecan plus 5-fluorouracil) in colorectal carcinoma can be predicted by tumour DNA content. Bendardaf, R., Lamlum, H., Ristamäki, R., Algars, A., Collan, Y., Pyrhönen, S. Oncology (2004) [Pubmed]
  5. Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions? Lorenzato, M., Caudroy, S., Bronner, C., Evrard, G., Simon, M., Durlach, A., Birembaut, P., Clavel, C. Hum. Pathol. (2005) [Pubmed]
  6. IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma. Shao, Z.M., Sheikh, M.S., Ordonez, J.V., Feng, P., Kute, T., Chen, J.C., Aisner, S., Schnaper, L., LeRoith, D., Roberts, C.T. Cancer Res. (1992) [Pubmed]
  7. Morphology and DNA content analysis in the evaluation of first trimester placentas for partial hydatidiform mole (PHM). Chew, S.H., Perlman, E.J., Williams, R., Kurman, R.J., Ronnett, B.M. Hum. Pathol. (2000) [Pubmed]
  8. Spindle cell squamous carcinoma of the esophagus: analysis of ploidy and tumor proliferative activity in a series of 13 cases. Lauwers, G.Y., Grant, L.D., Scott, G.V., Carr, N.J., Sobin, L.H. Hum. Pathol. (1998) [Pubmed]
  9. Differential effects of depleting agents on cytoplasmic and nuclear non-protein sulphydryls: a fluorescence image cytometry study. Thomas, M., Nicklee, T., Hedley, D.W. Br. J. Cancer (1995) [Pubmed]
  10. Effects of tamoxifen on potential doubling time of human breast cancer cell line determined by image cytometry of double fluorescent BrdU and DNA labeling. Rostagno, P., Moll, J.L., Birtwisle-Peyrottes, I., Ettore, F., Lagrange, J.L., Gioanni, J., Caldani, C. Anticancer Res. (1994) [Pubmed]
  11. Image cytometry DNA analysis of diethylnitrosamine-induced dysplasias and invasive squamous cell carcinomas of the esophagus in mice. Munck-Wikland, E., Kuylenstierna, R., Lindholm, J., Rubio, C. Acta Otolaryngol. (1990) [Pubmed]
  12. Paradoxical relationship between protein content and nucleolar activity in mammalian cardiomyocytes. Anatskaya, O.V., Vinogradov, A.E. Genome (2004) [Pubmed]
  13. Malignant rhabdoid tumor of the vulva: case report with cytological, immunohistochemical, ultrastructural and DNA ploidy studies and a review of the literature. Igarashi, T., Sasano, H., Konno, R., Sato, S., Namiki, T., Ohtani, H., Nagura, H., Yajima, A. Pathol. Int. (1998) [Pubmed]
  14. Increased cell proliferation in chronic Helicobacter pylori positive gastritis and gastric carcinoma--correlation between immuno-histochemistry and Tv image cytometry. Szaleczky, E., Prónai, L., Molnár, B., Berczi, L., Fehér, J., Tulassay, Z. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. (2000) [Pubmed]
  15. DNA quantitation by image cytometry of touch preparations from fresh and frozen tissue. Suit, P.F., Bauer, T.W. Am. J. Clin. Pathol. (1990) [Pubmed]
  16. Elevated expression of retinoic acid receptor-alpha (RAR alpha) in estrogen-receptor-positive breast carcinomas as detected by immunohistochemistry. Han, Q.X., Allegretto, E.A., Shao, Z.M., Kute, T.E., Ordonez, J., Aisner, S.C., Rishi, A.K., Fontana, J.A. Diagn. Mol. Pathol. (1997) [Pubmed]
  17. Single-cell measurement of superoxide anion and hydrogen peroxide production by human neutrophils with digital imaging fluorescence microscopy. Szucs, S., Vámosi, G., Póka, R., Sárváry, A., Bárdos, H., Balázs, M., Kappelmayer, J., Tóth, L., Szöllosi, J., Adány, R. Cytometry. (1998) [Pubmed]
  18. A strategy for multiple immunophenotyping by image cytometry: model studies using latex microbeads labeled with seven streptavidin-bound fluorochromes. Gothot, A., Grosdent, J.C., Paulus, J.M. Cytometry. (1996) [Pubmed]
  19. High-resolution image cytometry of rat sperm nuclear shape, size and chromatin status. Experimental validation with the reproductive toxicant vinclozolin. Auger, J., Lesaffre, C., Bazire, A., Schoevaert-Brossault, D., Eustache, F. Reprod. Toxicol. (2004) [Pubmed]
  20. Epidermal growth factor (EGF) and EGF receptor in hypospadias. el-Galley, R.E., Smith, E., Cohen, C., Petros, J.A., Woodard, J., Galloway, N.T. British journal of urology. (1997) [Pubmed]
  21. Angiopoietin-1, 2 and Tie2 expressions in endometrial adenocarcinoma--the Ang2 dominant balance up-regulates tumor angiogenesis in the presence of VEGF. Saito, M., Watanabe, J., Fujisawa, T., Kamata, Y., Nishimura, Y., Arai, T., Miyamoto, T., Obokata, A., Kuramoto, H. Eur. J. Gynaecol. Oncol. (2006) [Pubmed]
  22. The in vitro effect of desflurane preconditioning on endothelial adhesion molecules and mRNA expression. Biao, Z., Zhanggang, X., Hao, J., Changhong, M., Jing, C. Anesth. Analg. (2005) [Pubmed]
  23. Preneoplastic oral lesions: the clinical value of image cytometry DNA analysis, p53 and p21/WAF1 expression. Högmo, A., Lindskog, S., Lindholm, J., Kuylenstierna, R., Auer, G., Munck-Wikland, E. Anticancer Res. (1998) [Pubmed]
  24. Quantitative measurement of estrogen and progesterone receptors in breast lumps using image cytometry. Sarker, S.K., Mendiola, R., Walker, M., Coleman, D.V. Anal. Quant. Cytol. Histol. (1997) [Pubmed]
  25. Topographical analysis of p53 expression and DNA ploidy in early bronchial squamous cell carcinoma and preneoplastic lesions. Inage, Y., Ogata, T., Yamamoto, T., Akaogi, E., Horiguchi, H., Kamma, H., Satoh, Y., Ishikawa, S., Onizuka, M., Sakakibara, Y. Lung Cancer (2001) [Pubmed]
  26. Ki-67 labeling indices in non-small cell lung cancer: comparison between image cytometry and flow cytometry. Ishikuro, A., Dosaka-Akita, H., Kato, M., Fujino, M., Isobe, H., Miyamoto, H., Inoue, K., Kawakami, Y. Cytometry. (1997) [Pubmed]
  27. Oncogenic human papillomaviruses and ploidy in cervical lesions. Rihet, S., Lorenzato, M., Clavel, C. J. Clin. Pathol. (1996) [Pubmed]
  28. Checkpoint effectors CDKN1A and Gadd45 correlate with oxidative DNA damage in human prostate carcinoma. Giovannini, C., Chieco, P., Bertaccini, A., Gramantieri, L., Lacchini, M., Martorana, G. Anticancer Res. (2004) [Pubmed]
  29. Prognostic significance of DNA cytometry in carcinoma of the uterine cervix FIGO stage IB and II. Grote, H.J., Friedrichs, N., Pomjanski, N., Guhde, H.F., Reich, O., Böcking, A. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. (2001) [Pubmed]
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