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MeSH Review:

Tetracycline Resistance

Kunert, K.J. et al., Taylor, D.E. et al., Horaud, T. et al., Allmeier, H. et al., Frazier, C.L. et al., et al.

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Disease relevance of Tetracycline Resistance

Furthermore, the modified Ll.ltrB intron was used to separately deliver a phage resistance gene (abiD) and a tetracycline resistance marker (tetM) into mleS, without the need for selection to drive the integration or to maintain the integrant [1].
A tetracycline resistance (Tcr) gene that was found originally on two Bacteroides plasmids (pBF4 and pCP1) confers tetracycline resistance on Escherichia coli, but only when it is grown aerobically [2].
A tetracycline resistance (Tcr) determinant previously cloned from the Campylobacter jejuni plasmid pUA466 (D. E. Taylor, J. Bacteriol. 165:1037-1039, 1986) was localized by restriction endonuclease mapping, subcloning, and Tn1000 insertion mutagenesis to a 2-kilobase region consisting of 1.8- and 0.2-kilobase HincII fragments [3].
To study the function of glutathione reductase and glutathione in Escherichia coli the coding sequence of the bacterial glutathione reductase gene (gor gene) was cloned into the vector pBR322, and the gor gene was expressed under the control of the promoter of the tetracycline-resistance gene (tet gene) in different Escherichia coli strains [4].

High impact information on Tetracycline Resistance

pMV120 was reported to carry the tetracycline resistance (Tcr) determinant of class N. We obtained tetracycline-susceptible transconjugants harboring plasmids with restriction enzyme profiles indistinguishable from those of pMV120 isolated from tetracycline-resistant clones [5].
An improved method for recombination of mutations in pir-dependent, oriR6K vectors involved the use of plasmids containing genes for tetracycline resistance (TcR) [6].
It contains three 38-bp inverted repeats, and (in this order) a new orfI, a resolution site (res), genes encoding resolvase (tnpR), transposase (tnpA), tetracycline-resistance (TcR) repressor (tetR), TcR (tetA) and a truncated transposase gene (tnpA') [7].
The Apr and tetracycline resistance (Tcr) markers carried in pBR313 were derived from the ampicillin transposon (TnA) of pRSF2124 and pSC101 respectively [8].
In this study the presence of the blaCARB-2 (ampicillin), cmlA (chloramphenicol), aadA2 (streptomycin/spectinomycin), sul1 (sulphonamide), and tetG (tetracycline) resistance genes in isolates of one such phage type, U302, have been determined [9].

Biological context of Tetracycline Resistance

The tetracycline-resistance (TcR) genes in these plasmids are expressed constitutively and cells carrying these plasmids are resistant to tetracycline [10].

Associations of Tetracycline Resistance with chemical compounds

Tetracycline-resistance (Tcr) or erythromycin-resistance (EMr) strains of Uu (or Mh) had cross-resistance to erythromycin or tetracycline [11].

Gene context of Tetracycline Resistance

Escherichia coli strain which contains a marker of tetracycline resistance gene (TcR) placed by P1 transduction beside the chromosomal deletion of ampC gene (delta ampC) coding for beta-lactamase was constructed [12].
We have constructed a soybean genomic DNA library in Escherichia coli K12 strain KC13 using plasmid pPV33, which consists of a promoter-less tetracycline resistance (Tcr) gene [13].

References

Genetic manipulation of Lactococcus lactis by using targeted group II introns: generation of stable insertions without selection. Frazier, C.L., San Filippo, J., Lambowitz, A.M., Mills, D.A. Appl. Environ. Microbiol. (2003) [Pubmed]
Characterization of a novel tetracycline resistance that functions only in aerobically grown Escherichia coli. Speer, B.S., Salyers, A.A. J. Bacteriol. (1988) [Pubmed]
Characterization and expression of a cloned tetracycline resistance determinant from Campylobacter jejuni plasmid pUA466. Taylor, D.E., Hiratsuka, K., Ray, H., Manavathu, E.K. J. Bacteriol. (1987) [Pubmed]
Variations in the activity of glutathione reductase and the cellular glutathione content in relation to sensitivity to methylviologen in Escherichia coli. Kunert, K.J., Cresswell, C.F., Schmidt, A., Mullineaux, P.M., Foyer, C.H. Arch. Biochem. Biophys. (1990) [Pubmed]
Does a tetracycline resistance determinant of class N exist? Horaud, T., Delbos, F., Pepper, K. Antimicrob. Agents Chemother. (1990) [Pubmed]
Construction of new beta-glucuronidase cassettes for making transcriptional fusions and their use with new methods for allele replacement. Metcalf, W.W., Wanner, B.L. Gene (1993) [Pubmed]
Complete nucleotide sequence of Tn1721: gene organization and a novel gene product with features of a chemotaxis protein. Allmeier, H., Cresnar, B., Greck, M., Schmitt, R. Gene (1992) [Pubmed]
Construction and characterization of new cloning vehicles. I. Ampicillin-resistant derivatives of the plasmid pMB9. Bolivar, F., Rodriguez, R.L., Betlach, M.C., Boyer, H.W. Gene (1977) [Pubmed]
Variation in clonality and antibiotic-resistance genes among multiresistant Salmonella enterica serotype typhimurium phage-type U302 (MR U302) from humans, animals, and foods. Walker, R.A., Lindsay, E., Woodward, M.J., Ward, L.R., Threlfall, E.J. Microb. Drug Resist. (2001) [Pubmed]
Expression of tetracycline resistance in pBR322 derivatives reduces the reproductive fitness of plasmid-containing Escherichia coli. Lee, S.W., Edlin, G. Gene (1985) [Pubmed]
Antimycoplasmal activities of (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10 -[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid (YH-6) in comparison with other antibiotics in vitro. Ye, H., Wu, J.M., Yang, Y.S., Ji, R.Y., Chen, K.X. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999) [Pubmed]
Escherichia coli strain with a deletion of the chromosomal ampC gene marked with TcR, suitable for production of penicillin G acylase. Vizváryová, M., Stuchlík, S., Grones, J., Macor, M., Turna, J. Folia Microbiol. (Praha) (1999) [Pubmed]
Cloning of a promoter-like soybean DNA sequence responding to IAA induction in Escherichia coli K12. Kline, E.L., Chiang, S.J., Lattora, D., Chaung, W. J. Biochem. (1992) [Pubmed]

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