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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Mycology

  • RESEARCH DESIGN AND METHODS: Nail samples from 184 diabetic patients who exhibited symptoms consistent with toenail onychomycosis were screened for dermatophyte fungal infection using DTM, potassium hydroxide evaluation, and central mycology laboratory culture tests [1].
  • One hundred nine Gabonese patients infected with Loa loa microfilariae were treated with ivermectin (200 microg/kg of body weight) at the Parasitology, Mycology and Tropical Medicine Department (Faculte de Medecine et des Sciences de la Sante, Libreville, Gabon) [2].
  • With terbinafine, negative mycology at week 8 was 81.3% in the interdigital and 88.6% in the more extensive forms of tinea pedis; with itraconazole mycology was negative in 65.0% and 50.0% of patients, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)[3]

High impact information on Mycology

  • However, the prevalence of this fungus in CF patients may be underestimated due to the currently poor knowledge of this fungus in most of the medical mycology laboratories [4].
  • A formulation comprised of commercially available potato flakes, glucose, and agar provides a medium which is inexpensive, is easily prepared, and is particularly useful for the identification of mold fungi encountered in the clinical mycology laboratory [5].
  • The modified API 20C system (Analytab Products, Inc.) containing 19 carbohydrate assimilation tests was used to identify stock cultures of clinical isolates and routine clinical isolates from the Mayo Clinic mycology laboratory [6].
  • RESULTS: At week 48, a statistically significantly greater percentage of the terbinafine group than itraconazole group showed negative mycology (73% [119 of 163] vs 45.8% [77 of 168]; p < 0.0001) (difference = 27.2%; 95% CI = [17.0%, 37.3%]) [7].
  • However, only terbinafine gave progressive mycologic improvement such that at 5 weeks after treatment, 88% of the patients receiving terbinafine had converted from positive to negative mycology compared with 23% of the patients treated with vehicle [8].

Biological context of Mycology

  • Among the possible ways forward in medical mycology are improvements in the bioavailability of existing agents, more clinical testing of new agents and further development of the lipid formulations of amphotericin B [9].

Associations of Mycology with chemical compounds

  • The diagnosis was made on cytologic examination of the material processed according to the Papanicolaou technique, evaluated by Giemsa, Gram's, Grocott and chromotrope-2R modified trichrome preparations and by fungi-fluor fluorescent mycology stain [10].
  • Although the therapeutic role of ajoene, an organosulfur compound of garlic, in cardiovascular diseases and mycology has been established, its usefulness in cancer treatment has only recently been suggested [11].
  • The first part of the report deals with the physicochemical aspects, mycology, laboratory production, and natural occurrence in plant products and animal products of zearalenone [12].
  • Ninety strains of fungi from the collection of our mycology laboratory were tested in Galzy and Slonimski (GS) synthetic liquid medium for their ability to degrade the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) and its by-product, 2,4-dichlorophenol (2,4-DCP) at 100 mg l(-1), each [13].
  • The kit was reported as a method equivalent to the standardized guidelines for antifungal susceptibility testing by the Committee for Clinical Laboratory Standards-1994, the Japanese Society for Medical Mycology, and which is widely used in Japan for amphotericin B, flucytosine, fluconazole, miconazole, and itraconazole [14].

Gene context of Mycology

  • The API 20 C microtube system containing 20 biochemical tests for the identification of yeasts was compared with conventional tests used in the Mayo Clinic mycology laboratory [15].
  • For diagnostic applications, distinction among isolates to the species level was easily performed using polymerase chain reaction-based assays, which could be useful tools in the mycology laboratory, particularly for atypical isolates [16].
  • Antifungal activity of some deoxyhypusine synthase inhibitors (short communication: plant mycology and crop protection) [17].
  • GermWare Mycology is an image-rich, CD-ROM-based instruction divided into tutorial and reference programs [18].
  • It is recommended for routine use in mycology laboratories for following up patients on treatment and for confirming the diagnosis of sera that are weakly positive by ID [19].


  1. Dermatophyte test medium culture for evaluating toenail infections in patients with diabetes. Rich, P., Harkless, L.B., Atillasoy, E.S. Diabetes Care (2003) [Pubmed]
  2. Short- and long-term action of multiple doses of ivermectin on loiasis microfilaremia. Kombila, M., Duong, T.H., Ferrer, A., Perret, J.L., Marion, M.C., Nguiri, C., Gaxotte, P., Manfoumbi, M., Richard-Lenoble, D. Am. J. Trop. Med. Hyg. (1998) [Pubmed]
  3. Two-week oral treatment of tinea pedis, comparing terbinafine (250 mg/day) with itraconazole (100 mg/day): a double-blind, multicentre study. De Keyser, P., De Backer, M., Massart, D.L., Westelinck, K.J. Br. J. Dermatol. (1994) [Pubmed]
  4. Airway colonization by Acrophialophora fusispora in patients with cystic fibrosis. Cimon, B., Challier, S., Béguin, H., Carrère, J., Chabasse, D., Bouchara, J.P. J. Clin. Microbiol. (2005) [Pubmed]
  5. Use of potato flakes agar in clinical mycology. Rinaldi, M.G. J. Clin. Microbiol. (1982) [Pubmed]
  6. Evaluation of the modified API 20C system for identification of clinically important yeasts. Buesching, W.J., Kurek, K., Roberts, G.D. J. Clin. Microbiol. (1979) [Pubmed]
  7. Twelve weeks of continuous oral therapy for toenail onychomycosis caused by dermatophytes: a double-blind comparative trial of terbinafine 250 mg/day versus itraconazole 200 mg/day. De Backer, M., De Vroey, C., Lesaffre, E., Scheys, I., De Keyser, P. J. Am. Acad. Dermatol. (1998) [Pubmed]
  8. Efficacy of a 1-week, twice-daily regimen of terbinafine 1% cream in the treatment of interdigital tinea pedis. Results of placebo-controlled, double-blind, multicenter trials. Berman, B., Ellis, C., Leyden, J., Lowe, N., Savin, R., Shupack, J., Stiller, M., Tschen, E., Zaias, N., Birnbaum, J.E. J. Am. Acad. Dermatol. (1992) [Pubmed]
  9. The search for new antifungal drugs and strategies continues. Jack, D.B. Drug News Perspect. (1998) [Pubmed]
  10. Pulmonary microsporidiosis in a patient with the acquired immunodeficiency syndrome. A case report. Remadi, S., Dumais, J., Wafa, K., MacGee, W. Acta Cytol. (1995) [Pubmed]
  11. The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis. Tilli, C.M., Stavast-Kooy, A.J., Vuerstaek, J.D., Thissen, M.R., Krekels, G.A., Ramaekers, F.C., Neumann, H.A. Arch. Dermatol. Res. (2003) [Pubmed]
  12. Risk assessment of the mycotoxin zearalenone. Kuiper-Goodman, T., Scott, P.M., Watanabe, H. Regulatory toxicology and pharmacology : RTP. (1987) [Pubmed]
  13. Fungal bioconversion of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4-dichlorophenol (2,4-DCP). Vroumsia, T., Steiman, R., Seigle-Murandi, F., Benoit-Guyod, J.L. Chemosphere (2005) [Pubmed]
  14. Multicenter evaluation of commercial frozen plates for microdilution broth antifungal susceptibility testing of yeasts and comparison of MIC limits recommended in NCCLS M27-A2. Makimura, K., Oguri, T., Mikami, Y., Kume, H., Hanazawa, R., Abe, M., Ikeda, R., Shinoda, T. Microbiol. Immunol. (2005) [Pubmed]
  15. Evaluation of the API 20 c microtube system for the identification of clinically important yeasts. Roberts, G.D., Wang, H.S., Hollick, G.E. J. Clin. Microbiol. (1976) [Pubmed]
  16. Molecular approaches to the study of dermatophytes. Kac, G. Med. Mycol. (2000) [Pubmed]
  17. Antifungal activity of some deoxyhypusine synthase inhibitors (short communication: plant mycology and crop protection). Mackintosh, C.A., Walters, D.R. Mycopathologia (2003) [Pubmed]
  18. Mycology at a distance. Koneman, E., Gade, W. Clinical laboratory science : journal of the American Society for Medical Technology. (2002) [Pubmed]
  19. Counterimmunoelectrophoresis in the diagnosis of mycetoma and its sensitivity as compared to immunodiffusion. Gumaa, S.A., Mahgoub, E.S. Sabouraudia. (1975) [Pubmed]
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