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Chemical Compound Review

Acid Red 29     (3E)-5-hydroxy-4-oxo-3...

Synonyms: AC1NV8PE, C.I. 16570
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Disease relevance of Fast fuchsine G


High impact information on Fast fuchsine G

  • In situ hybridization combined with histochemical staining with chromotrope 2R indicate that most of the cells expressing MCP-1 mRNA at these time points are primarily eosinophils [4].
  • Counterstaining with chromotrope 2R demonstrated that virtually all cells expressing TNF-alpha message were eosinophils [5].
  • Eo/B colonies, especially carbol chromotrope 2R+ cells, selected at Days 10, 14, and 18 from atopic donors contained messenger RNA for GM-CSF by combined in situ reverse transcription-polymerase chain reaction and cytochemistry, and demonstrated time-dependent expression of GM-CSF by immunocytochemistry (P = 0.007) [6].
  • Furthermore, RANTES mRNA localized to carbol chromotrope 2R-positive colony cells, as assessed using in situ RT-PCR on day 21 of culture in semisolid media, and was found to gradually decrease (relative to beta2-microglobulin) in rhIL-3- and rhIL-5-treated colony cells (comprising > 90% eosinophil-like cells) up to day 28 [7].
  • Approximately 90% of the TGF-beta 2 positive cells detected in the sections taken at day 78 also stained with chromotrope 2R used to detect eosinophils and the morphology of approximately 50% of these cells was characteristic of eosinophils.(ABSTRACT TRUNCATED AT 250 WORDS)[8]

Biological context of Fast fuchsine G

  • The diagnosis was made on cytologic examination of the material processed according to the Papanicolaou technique, evaluated by Giemsa, Gram's, Grocott and chromotrope-2R modified trichrome preparations and by fungi-fluor fluorescent mycology stain [9].
  • CONCLUSION: Detection of microsporidia in bile can be achieved using several different stains routinely available to cytologists, most optimally with alcohol-fixed Papanicolaou- or Giemsa-stained preparations or with Chromotrope 2R stain, which is available in parasitology laboratories [10].

Anatomical context of Fast fuchsine G


Associations of Fast fuchsine G with other chemical compounds


Gene context of Fast fuchsine G

  • The RRS methods have high sensitivity for the determination of protein, the detection limits for bovine serum albumin (BSA) are 10.0 - 30.2 ng/ml, and the sensitivity order is CALKS > AAI = CPAI > ACBK = CT2R > ACDB > CBSE [14].

Analytical, diagnostic and therapeutic context of Fast fuchsine G


  1. Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1). Ohno, I., Lea, R.G., Flanders, K.C., Clark, D.A., Banwatt, D., Dolovich, J., Denburg, J., Harley, C.B., Gauldie, J., Jordana, M. J. Clin. Invest. (1992) [Pubmed]
  2. Tissue diagnosis of intestinal microsporidiosis using the chromotrope-2R modified trichrome stain. Giang, T.T., Kotler, D.P., Garro, M.L., Orenstein, J.M. Arch. Pathol. Lab. Med. (1993) [Pubmed]
  3. Prolonged asymptomatic dense deposit disease in Chinese. Report of 2 cases in Taiwan. Mao, T., Wu, K., Yang, Y., Hsu, H. American journal of nephrology. (1998) [Pubmed]
  4. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. Zhang, K., Gharaee-Kermani, M., Jones, M.L., Warren, J.S., Phan, S.H. J. Immunol. (1994) [Pubmed]
  5. TNF-alpha production by eosinophils in upper airways inflammation (nasal polyposis). Finotto, S., Ohno, I., Marshall, J.S., Gauldie, J., Denburg, J.A., Dolovich, J., Clark, D.A., Jordana, M. J. Immunol. (1994) [Pubmed]
  6. Enhanced expression of GM-CSF in differentiating eosinophils of atopic and atopic asthmatic subjects. Gauvreau, G.M., O'Byrne, P.M., Moqbel, R., Velazquez, J., Watson, R.M., Howie, K.J., Denburg, J.A. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  7. Interleukin-4 and RANTES expression in maturing eosinophils derived from human cord blood CD34+ progenitors. Velazquez, J.R., Lacy, P., Mahmudi-Azer, S., Bablitz, B., Milne, C.D., Denburg, J.A., Moqbel, R. Immunology (2000) [Pubmed]
  8. Accumulation of chromotrope 2R positive cells in equine endometrium during early pregnancy and expression of transforming growth factor-beta 2 (TGF-beta 2). Lea, R.G., Stewart, F., Allen, W.R., Ohno, I., Clark, D.A. J. Reprod. Fertil. (1995) [Pubmed]
  9. Pulmonary microsporidiosis in a patient with the acquired immunodeficiency syndrome. A case report. Remadi, S., Dumais, J., Wafa, K., MacGee, W. Acta Cytol. (1995) [Pubmed]
  10. Cytologic detection of microsporidia spores in bile. A comparison of stains. Joste, N.E., Sax, P.E., Pieciak, W.S. Acta Cytol. (1999) [Pubmed]
  11. Asymptomatic Enterocytozoon bieneusi microsporidiosis in captive mammals. Slodkowicz-Kowalska, A., Graczyk, T.K., Tamang, L., Girouard, A.S., Majewska, A.C. Parasitol. Res. (2007) [Pubmed]
  12. Increased expression of high affinity IgE (FcepsilonRI) receptor-alpha chain mRNA and protein-bearing eosinophils in human allergen-induced atopic asthma. Rajakulasingam, K., Till, S., Ying, S., Humbert, M., Barkans, J., Sullivan, M., Meng, Q., Corrigan, C.J., Bungre, J., Grant, J.A., Kay, A.B., Durham, S.R. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  13. Declining CD4+ T-lymphocyte counts are associated with increased risk of enteric parasitosis and chronic diarrhea: results of a 3-year longitudinal study. Navin, T.R., Weber, R., Vugia, D.J., Rimland, D., Roberts, J.M., Addiss, D.G., Visvesvara, G.S., Wahlquist, S.P., Hogan, S.E., Gallagher, L.E., Juranek, D.D., Schwartz, D.A., Wilcox, C.M., Stewart, J.M., Thompson, S.E., Bryan, R.T. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (1999) [Pubmed]
  14. Resonance Rayleigh-scattering method for the determination of proteins with some monoazo dyes of chromotropic acid. Liu, S.P., Liu, Q. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2001) [Pubmed]
  15. Production of monoclonal antibodies directed against the microsporidium Enterocytozoon bieneusi. Accoceberry, I., Thellier, M., Desportes-Livage, I., Achbarou, A., Biligui, S., Danis, M., Datry, A. J. Clin. Microbiol. (1999) [Pubmed]
  16. A patient with acquired immunodeficiency syndrome and untreated Encephalitozoon (Septata) intestinalis microsporidiosis leading to small bowel perforation. Response to albendazole. Soule, J.B., Halverson, A.L., Becker, R.B., Pistole, M.C., Orenstein, J.M. Arch. Pathol. Lab. Med. (1997) [Pubmed]
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