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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Skin Aging

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Disease relevance of Skin Aging


High impact information on Skin Aging

  • All-trans retinoic acid protects against both of these deleterious effects and may thereby retard premature skin aging [5].
  • The data presented provide evidence suggesting that the UV-A excitation of trans-urocanic acid initiates chemical processes that result in the photoaging of skin [6].
  • Thus, PTH and PTHrP may play an important role in the normal physiology of skin, and their agonists and antagonists have potentially wide therapeutic applications in the treatment of hyperproliferative skin disorders and aging skin and could also be effective in stimulating and maintaining hair growth [7].
  • We conclude that in HFFs, AGE-RAGE interactions may influence the process of skin aging through mild stimulation of ECM gene expression [8].
  • Thus, the induction and regulation of endogenous antioxidant enzymes including catalase may offer a strategy for preventing and treating skin aging [9].

Biological context of Skin Aging


Anatomical context of Skin Aging

  • As matrix metalloproteinase levels are known to rise in fibroblasts as a function of age, and as oxidant stress is believed to underlie changes associated with both photoaging and natural aging, we determined whether natural skin aging, like photoaging, gives rise to increased matrix metalloproteinases and reduced collagen synthesis [12].

Associations of Skin Aging with chemical compounds


Gene context of Skin Aging

  • Taken together, the above data suggest that EGFR plays dominant role in the crosstalk among growth factor receptor and cytokine receptors leading to the activation of c-Jun kinase upon UV irradiation, and that EGFR could be one of the targets for clinical and cosmetical prevention of UV-induced skin aging [18].
  • Repeated exposure to solar ultraviolet radiation results in premature skin aging due, in part, to the degradation of dermal collagen by fibroblast collagenase (matrix metalloproteinase 1 [MMP-1]) [19].
  • These results suggest that the increased level of COX-2 and higher level of PGE(2) in aged cells may play an important role in cellular senescence, and that selective COX-2 inhibitors may be useful for the intervention of skin aging [20].
  • Loss of EPC-1/PEDF expression during skin aging in vivo [21].
  • This paper shows the evidence for the role of tobacco smoking in skin aging and describes how modulation of TGF-beta1 levels might retard premature skin aging [22].


  1. Skin protection by sucralfate cream during electron beam therapy. Maiche, A., Isokangas, O.P., Gröhn, P. Acta oncologica (Stockholm, Sweden) (1994) [Pubmed]
  2. The use of endogenous antioxidants to improve photoprotection. Steenvoorden, D.P., van Henegouwen, G.M. J. Photochem. Photobiol. B, Biol. (1997) [Pubmed]
  3. The effects of tretinoin on random skin flap survival in the swine model. Canady, J.W., Thompson, S.A. Annals of plastic surgery. (1994) [Pubmed]
  4. The relationship between facial wrinkling and airflow obstruction. Lange, P., Schnohr, P. International journal of dermatology. (1994) [Pubmed]
  5. c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid. Fisher, G.J., Datta, S., Wang, Z., Li, X.Y., Quan, T., Chung, J.H., Kang, S., Voorhees, J.J. J. Clin. Invest. (2000) [Pubmed]
  6. Epidermal trans-urocanic acid and the UV-A-induced photoaging of the skin. Hanson, K.M., Simon, J.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice. Holick, M.F., Ray, S., Chen, T.C., Tian, X., Persons, K.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha. Lohwasser, C., Neureiter, D., Weigle, B., Kirchner, T., Schuppan, D. J. Invest. Dermatol. (2006) [Pubmed]
  9. H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo. Shin, M.H., Rhie, G.E., Kim, Y.K., Park, C.H., Cho, K.H., Kim, K.H., Eun, H.C., Chung, J.H. J. Invest. Dermatol. (2005) [Pubmed]
  10. Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence. Han, Y.H., Kim, H.S., Kim, J.M., Kim, S.K., Yu, D.Y., Moon, E.Y. FEBS Lett. (2005) [Pubmed]
  11. Studies on skin aging. Preparation and properties of fucose-rich oligo- and polysaccharides. Effect on fibroblast proliferation and survival. Péterszegi, G., Isnard, N., Robert, A.M., Robert, L. Biomed. Pharmacother. (2003) [Pubmed]
  12. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. Varani, J., Warner, R.L., Gharaee-Kermani, M., Phan, S.H., Kang, S., Chung, J.H., Wang, Z.Q., Datta, S.C., Fisher, G.J., Voorhees, J.J. J. Invest. Dermatol. (2000) [Pubmed]
  13. Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin. Shin, M.H., Rhie, G.E., Park, C.H., Kim, K.H., Cho, K.H., Eun, H.C., Chung, J.H. J. Invest. Dermatol. (2005) [Pubmed]
  14. Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes. Meves, A., Stock, S.N., Beyerle, A., Pittelkow, M.R., Peus, D. J. Invest. Dermatol. (2002) [Pubmed]
  15. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats. Eşrefoğlu, M., Seyhan, M., Gül, M., Parlakpinar, H., Batçioğlu, K., Uyumlu, B. J. Pineal Res. (2005) [Pubmed]
  16. Does estrogen prevent skin aging? Results from the First National Health and Nutrition Examination Survey (NHANES I). Dunn, L.B., Damesyn, M., Moore, A.A., Reuben, D.B., Greendale, G.A. Archives of dermatology. (1997) [Pubmed]
  17. Topical tretinoin in the treatment of aging skin. Weiss, J.S., Ellis, C.N., Headington, J.T., Voorhees, J.J. J. Am. Acad. Dermatol. (1988) [Pubmed]
  18. EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes. Wan, Y.S., Wang, Z.Q., Voorhees, J., Fisher, G. Cell. Signal. (2001) [Pubmed]
  19. Induction of mRNA for matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 in human skin in vivo by solar simulated radiation. Lahmann, C., Young, A.R., Wittern, K.P., Bergemann, J. Photochem. Photobiol. (2001) [Pubmed]
  20. Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts. Han, J.H., Roh, M.S., Park, C.H., Park, K.C., Cho, K.H., Kim, K.H., Eun, H.C., Chung, J.H. Mech. Ageing Dev. (2004) [Pubmed]
  21. Loss of EPC-1/PEDF expression during skin aging in vivo. Francis, M.K., Appel, S., Meyer, C., Balin, S.J., Balin, A.K., Cristofalo, V.J. J. Invest. Dermatol. (2004) [Pubmed]
  22. Tobacco smoke extract induces age-related changes due to modulation of TGF-beta. Yin, L., Morita, A., Tsuji, T. Exp. Dermatol. (2003) [Pubmed]
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