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MeSH Review


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Disease relevance of Rejuvenation


Psychiatry related information on Rejuvenation

  • Thiazolidinediones, in particular, have received much attention, not only for the well documented hepatotoxicity of troglitazone that led to its removal from the market in 2000, but also for the emerging data that support the beneficial effects of the thiazolidinedione class of drugs on beta-cell rejuvenation and cardiovascular risk reduction [3].

High impact information on Rejuvenation

  • Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells [4].
  • We find that interaction of DnaA protein with oriC DNA is needed to stabilize DnaA protein during this rejuvenation process [5].
  • This trend risks replicating both the rejuvenation fads of a century ago and the recent experience in estrogen therapy for menopause that has been propelled for decades by advocacy substituting for reliable scientific evidence [6].
  • There was no difference in hypoxanthine, inosine, and uric acid levels in the rejuvenated and nonrejuvenated units, which indicated that the chemicals in the rejuvenation solution and their by-products had been removed during processing [7].
  • CONCLUSIONS: RBCs stored in CPD-saline-adenine-glucose-mannitol do show a progressive loss of oxygen-dependent metabolic modulation, which is not restored after rejuvenation and which seems partly related to modifications in membrane proteins, mainly band 3 [8].

Biological context of Rejuvenation


Anatomical context of Rejuvenation


Associations of Rejuvenation with chemical compounds


Gene context of Rejuvenation

  • Hence in the elderly priming with GHRH is not capable to induce a rejuvenation of sleep endocrine activity [19].
  • Does the road to muscle rejuvenation go through Notch [20]?
  • This is an important consideration for therapy involving treatment of old animals with IL-7 of which there are reports indicating some rejuvenation of the thymus following IL-7 treatment, which is never complete [21].
  • The GOT activities in RBCs demonstrated a rejuvenation of the RBC population in the HDB group (6.4 +/- 2.5 U/g Hb) and HDA group (5.9 +/- 3.1 U/g Hb) compared to group C (3.9 +/- 1.3 U/g Hb).(ABSTRACT TRUNCATED AT 250 WORDS)[22]
  • METHODS: Two subjects undergoing facial rejuvenation procedures were analyzed before and after therapy using a 30-mm, three-dimensional microtopography imaging system (PRIMOS, GFM, Teltow, Germany) [23].

Analytical, diagnostic and therapeutic context of Rejuvenation


  1. Prostate cancer in men using testosterone supplementation. Gaylis, F.D., Lin, D.W., Ignatoff, J.M., Amling, C.L., Tutrone, R.F., Cosgrove, D.J. J. Urol. (2005) [Pubmed]
  2. Long-term prospective follow-up of botulinum toxin treatment for facial rhytides. Bulstrode, N.W., Grobbelaar, A.O. Aesthetic plastic surgery. (2002) [Pubmed]
  3. Thiazolidinediones and insulin: rationale for use and role of combination therapy in type 2 diabetes mellitus. Huang, A., Raskin, P. Treatments in endocrinology. (2005) [Pubmed]
  4. Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells. Allsopp, R.C., Cheshier, S., Weissman, I.L. J. Exp. Med. (2002) [Pubmed]
  5. The chromosome origin of Escherichia coli stabilizes DnaA protein during rejuvenation by phospholipids. Crooke, E., Castuma, C.E., Kornberg, A. J. Biol. Chem. (1992) [Pubmed]
  6. Andropause: invention, prevention, rejuvenation. Handelsman, D.J., Liu, P.Y. Trends Endocrinol. Metab. (2005) [Pubmed]
  7. Effect of rejuvenation and frozen storage on 42-day-old AS-1 RBCs. Szymanski, I.O., Teno, R.A., Lockwood, W.B., Hudgens, R., Johnson, G.S. Transfusion (2001) [Pubmed]
  8. Blood bank conditions and RBCs: the progressive loss of metabolic modulation. Messana, I., Ferroni, L., Misiti, F., Girelli, G., Pupella, S., Castagnola, M., Zappacosta, B., Giardina, B. Transfusion (2000) [Pubmed]
  9. Hyaluronic acid and its use as a "rejuvenation" agent in cosmetic dermatology. Andre, P. Seminars in cutaneous medicine and surgery. (2004) [Pubmed]
  10. Changes in fluidity of erythrocyte membranes after storage of erythrocytes and regeneration of cellular ATP level. Jarolím, P., Mircevová, L. Biochim. Biophys. Acta (1982) [Pubmed]
  11. Effects of rejuvenation of blood on 2,3-diphosphoglycerate and adenosine triphosphate and mechanical resistance of red blood cells. Hong, T.V., Wuilleret, B. Vox Sang. (1975) [Pubmed]
  12. The effect of multiparity and lactation periods on the graft versus host reactivity of thymocytes and splenocytes from aging C57BL mice. Skowron-Cendrzak, A., Basta-Kaim, A., Kubera, M. Mech. Ageing Dev. (1996) [Pubmed]
  13. Early results of vermilion lip augmentation using acellular allogeneic dermis: an adjunct in facial rejuvenation. Rohrich, R.J., Reagan, B.J., Adams, W.P., Kenkel, J.M., Beran, S.J. Plast. Reconstr. Surg. (2000) [Pubmed]
  14. Therapeutic effectiveness and safety of outdated human red blood cells rejuvenated to improve oxygen transport function, frozen for about 1.5 years at 80 C, washed, and stored at 4 C for 24 hours prior to rapid infusion. Valeri, C.R., Zaroulis, C.G., Vecchione, J.J., Valeri, D.A., Anastasi, J., Pivacek, L.E., Emerson, C.P. Transfusion (1980) [Pubmed]
  15. Phosphoenolpyruvate in the rejuvenation of stored red cells in SAGM medium: optimal conditions and the indirect effect of methemoglobin formation. Matsuyama, H., Niklasson, F., de Verdier, C.H., Högman, C.F. Transfusion (1989) [Pubmed]
  16. Freezing in the primary polyvinylchloride plastic collection bag: a new system for preparing and freezing nonrejuvenated and rejuvenated red blood cells. Valeri, C.R., Valeri, D.A., Anastasi, J., Vecchione, J.J., Dennis, R.C., Emerson, C.P. Transfusion (1981) [Pubmed]
  17. Effects of CO2 laser pulse duration in ablation and residual thermal damage: implications for skin resurfacing. Ross, E.V., Domankevitz, Y., Skrobal, M., Anderson, R.R. Lasers in surgery and medicine. (1996) [Pubmed]
  18. Experimental model for the long-term effects of laser resurfacing. Babovic, S., Trevino, M.T., Petty, P.M. Lasers in surgery and medicine. (2001) [Pubmed]
  19. Longtime administration of growth hormone-releasing hormone (GHRH) does not restore the reduced efficiency of GHRH on sleep endocrine activity in 2 old-aged subjects--a preliminary study. Murck, H., Frieboes, R.M., Schier, T., Steiger, A. Pharmacopsychiatry (1997) [Pubmed]
  20. Does the road to muscle rejuvenation go through Notch? Miller, J.B., Emerson, C.P. Science of aging knowledge environment [electronic resource] : SAGE KE (2003) [Pubmed]
  21. T cell development, ageing and Interleukin-7. Aspinall, R. Mech. Ageing Dev. (2006) [Pubmed]
  22. Red blood cell density distribution in uremic patients on acetate and bicarbonate hemodialysis. Hampl, H., Riedel, E., Wendel, G., Scigalla, P. Blood Purif. (1990) [Pubmed]
  23. 3D in-vivo optical skin imaging for topographical quantitative assessment of non-ablative laser technology. Friedman, P.M., Skover, G.R., Payonk, G., Kauvar, A.N., Geronemus, R.G. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2002) [Pubmed]
  24. Effect of hormonal steroids on lactate dehydrogenase activity and its isozymes in the coagulating gland of castrated male rats. Pereira, B.M., Balasubramanian, K., Govindarajulu, P. Int. J. Androl. (1981) [Pubmed]
  25. Soft-tissue fillers for wrinkles, folds and volume augmentation. Jordan, D.R. Can. J. Ophthalmol. (2003) [Pubmed]
  26. The role of facial skeletal augmentation and dental restoration in facial rejuvenation. Bains, J.W., Elia, J.P. Aesthetic plastic surgery. (1994) [Pubmed]
  27. A new option for volumetric restoration: poly-l-lactic acid. Thioly-Bensoussan, D. Journal of the European Academy of Dermatology and Venereology : JEADV. (2006) [Pubmed]
  28. Controversies in skin resurfacing: the role of erbium. Fleming, D. Journal of cutaneous laser therapy. (1999) [Pubmed]
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