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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Drug Synergism

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Disease relevance of Drug Synergism


Psychiatry related information on Drug Synergism


High impact information on Drug Synergism


Anatomical context of Drug Synergism


Associations of Drug Synergism with chemical compounds

  • For all anaesthetics studied except alpha-chloralose, at least one of the mutations above abolished drug potentiation of agonist responses at GABA(A) and glycine receptors. alpha-Chloralose produced efficacious direct activation of the GABA(A) alpha(2)beta(1) receptor (a 'GABA-mimetic' effect) [13].
  • Complications of irradiation related to apparent drug potentiation by adriamycin [14].
  • The present combination regimen consisting of mitomycin C, vinorelbine, carboplatin and granulocyte-macrophage colony-stimulating factor (GM-CSF) was chosen because of the known activity of these agents in NSCLC and their potential drug synergism without (nonhematologic) cross-toxicity [15].
  • We have investigated the potential drug synergism between Idarubicin (IDA) and Taxotere (TXR) that may be active in the ara-C and ASNase double drug-resistant cell lines [16].
  • We further examined the drug synergism between PEG-ASNase and the protease inhibitor Saquinavir (SAQ), both alone and in combination with nucleoside analog reverse transcriptase inhibitors (NRTI) [17].

Gene context of Drug Synergism

  • In light of these structural restrictions on drug potentiation, and since these surfactants are active at relatively low concentrations (below 1 microgram/ml), investigations of their mechanism of action were initiated by exploring specific interactions with P-glycoprotein [18].


  1. Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus. Crumpacker, C.S., Kowalsky, P.N., Oliver, S.A., Schnipper, L.E., Field, A.K. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  2. Analysis of the drug synergism between thymidine and arabinosyl cytosine using mouse S49 T lymphoma mutants. Cohen, A., Ullman, B. Cancer Chemother. Pharmacol. (1985) [Pubmed]
  3. Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells. Avramis, V.I., Nandy, P., Kwock, R., Solorzano, M.M., Mukherjee, S.K., Danenberg, P., Cohen, L.J. Anticancer Res. (1998) [Pubmed]
  4. Phase I trial of retinoic acid and cis-platinum for advanced squamous cell cancer of the head and neck based on experimental evidence of drug synergism. Weisman, R.A., Christen, R., Los, G., Jones, V., Kerber, C., Seagren, S., Glassmeyer, S., Orloff, L.A., Wong, W., Kirmani, S., Howell, S. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1998) [Pubmed]
  5. Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. Peterson, S.L. Eur. J. Pharmacol. (1991) [Pubmed]
  6. Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism. Cadman, E., Heimer, R., Davis, L. Science (1979) [Pubmed]
  7. Re: W. R. Greco et al., Application of a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-beta-D-arabinofuranosylcytosine. Cancer Res., 50: 5318-5327, 1990. Berenbaum, M.C. Cancer Res. (1992) [Pubmed]
  8. Re: W. R. Greco et al., Application of a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-beta-D-arabinofuranosylcytosine. Cancer Res., 50: 5318-5327, 1990. Sühnel, J. Cancer Res. (1992) [Pubmed]
  9. Synergistic cell inactivation of human NHIK 3025 cells by cinnamaldehyde in combination with cis-diamminedichloroplatinum(II). Dornish, J.M., Pettersen, E.O., Oftebro, R. Cancer Res. (1988) [Pubmed]
  10. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Onyewu, C., Blankenship, J.R., Del Poeta, M., Heitman, J. Antimicrob. Agents Chemother. (2003) [Pubmed]
  11. Potentiation of the antimalarial agent rufigallol. Winter, R.W., Cornell, K.A., Johnson, L.L., Ignatushchenko, M., Hinrichs, D.J., Riscoe, M.K. Antimicrob. Agents Chemother. (1996) [Pubmed]
  12. Determination of drug synergism between the tyrosine kinase inhibitors NSC 680410 (adaphostin) and/or STI571 (imatinib mesylate, Gleevec) with cytotoxic drugs against human leukemia cell lines. Avramis, I.A., Laug, W.E., Sausville, E.A., Avramis, V.I. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  13. The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Krasowski, M.D., Harrison, N.L. Br. J. Pharmacol. (2000) [Pubmed]
  14. Complications of irradiation related to apparent drug potentiation by adriamycin. Mayer, E.G., Poulter, C.A., Aristizabal, S.A. Int. J. Radiat. Oncol. Biol. Phys. (1976) [Pubmed]
  15. Mitomycin C, vinorelbine, carboplatin plus granulocyte-macrophage colony-stimulating factor for treatment of advanced non-small cell lung carcinoma. Hejna, M., Kornek, G.V., Raderer, M., Marosi, L., Schneeweiss, B., Greul, R., Weinländer, G., Valencak, J., Huber, H., Scheithauer, W. Oncology (1998) [Pubmed]
  16. The combination regimen of idarubicin and taxotere is effective against human drug-resistant leukemic cell lines. Majlessipour, F., Avramis, I.A., Kwock, R., Weinberg, K.I., Avrami, V.I. Anticancer Res. (2002) [Pubmed]
  17. Synergistic antiviral effect of PEG-asparaginase (ONCASPAR), with protease inhibitor alone and in combination with RT inhibitors against HIV-1 infected T-cells: a model of HIV-1-induced T-cell lymphoma. Avramis, V.I., Kwock, R., Avramis, I.A., Cohen, L.J., Inderlied, C. In Vivo (2001) [Pubmed]
  18. Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters. Buckingham, L.E., Balasubramanian, M., Safa, A.R., Shah, H., Komarov, P., Emanuele, R.M., Coon, J.S. Int. J. Cancer (1996) [Pubmed]
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