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Disease relevance of Dyspareunia


Psychiatry related information on Dyspareunia

  • This article describes an integrated treatment, where adjunctive sildenafil use was an important strategic component in the sex therapy of a couple's unconsummated marriage in which the wife's vaginismus, dyspareunia, and anorgasmia was complicated by her husband's ED and retarded ejaculation (RE) [6].

High impact information on Dyspareunia

  • The therapy (combined contraceptive pill and estrogen cream) had a marked effect on urogenital symptoms (vaginal dryness, dyspareunia, urinary frequency, and urinary urgency), with impressive improvement comparably in both groups [7].
  • During tamoxifen the most frequent complaints were hot flushes (85%), disturbed sleep (55%), vaginal dryness and/or dyspareunia (47%), decreased sexual desire (44%) and musculo-skeletal symptoms (43%) [8].
  • Women treated with tibolone report significant reductions in vaginal dryness and dyspareunia, effects that may be secondary to both estrogenic and androgenic actions [9].
  • RESULTS: At 6 months of treatment, a significant reduction in deep dyspareunia was observed in both groups, with goserelin superior to the OC at linear analog scale assessment [10].
  • Both dyspareunia and chronic pain were significantly reduced by the gestrinone treatment [11].

Chemical compound and disease context of Dyspareunia

  • Sildenafil seems to improve arousal, orgasm and sexual enjoyment, and dyspareunia in women affected by type 1 diabetes [12].
  • The 41 women with no identifiable laparoscopic abnormality did not differ significantly from the 95 with pelvic abnormalities in respect of age, parity, duration of pain, frequency of dysmenorrhoea and dyspareunia or the presence of gastro-intestinal or urinary symptoms [13].
  • Women allocated polyglactin 910 were less likely to have dyspareunia (8% versus 13%; RR 0.59, 95% CI 0.39 to 0.91; 2P = 0.02) and less likely to fail to resume pain-free intercourse (8% versus 14%; RR 0.57, 95% CI 0.38 to 0.87; 2P < 0.01) [14].
  • CONCLUSION: Topical nitroglycerin is safe and effective in providing temporary relief of introital dyspareunia and vulvar pain in women with vulvodynia [15].
  • Hormonal therapy with danazol or with leuprolide resulted in reduction of symptoms but was associated with amenorrhea in both cases and with dyspareunia in the second patient [16].

Biological context of Dyspareunia

  • Certain types of estrogen therapy were associated with increased frequency of sexual activity, enjoyment, desire, arousal, fantasies, satisfaction, vaginal lubrication, and feeling physically attractive, and reduced dyspareunia, vaginal dryness, and sexual problems [17].

Gene context of Dyspareunia

  • Musculoskeletal pain and dyspareunia significantly increased under first-line non-steroidal aromatase inhibitors (p=0.0039 and p=0.001, respectively), while patients under tamoxifen had significant decrease in sexual interest (p< or =0.0001) [18].


  1. Preservation of ovarian function by ovarian transposition performed before pelvic irradiation during childhood. Thibaud, E., Ramirez, M., Brauner, R., Flamant, F., Zucker, J.M., Fékété, C., Rappaport, R. J. Pediatr. (1992) [Pubmed]
  2. Buserelin acetate in the treatment of pelvic pain associated with minimal and mild endometriosis: a controlled study. Fedele, L., Bianchi, S., Bocciolone, L., Di Nola, G., Franchi, D. Fertil. Steril. (1993) [Pubmed]
  3. Estrogen therapy in the management of problems associated with urogenital ageing: a simple diagnostic test and the effect of the route of hormone administration. Notelovitz, M. Maturitas. (1995) [Pubmed]
  4. The role of the levonorgestrel-releasing intrauterine device in the management of symptomatic endometriosis. Vercellini, P., Viganò, P., Somigliana, E. Current opinion in obstetrics & gynecology. (2005) [Pubmed]
  5. Current considerations of the menopause. Wu, C.H. Ann. Clin. Lab. Sci. (1985) [Pubmed]
  6. FSD partner issues: expanding sex therapy with sildenafil. Perelman, M.A. Journal of sex & marital therapy. (2002) [Pubmed]
  7. The use of two estrogen preparations (a combined contraceptive pill versus conjugated estrogen cream) intravaginally to treat urogenital symptoms in postmenopausal Thai women: a comparative study. Chompootaweep, S., Nunthapisud, P., Trivijitsilp, P., Sentrakul, P., Dusitsin, N. Clin. Pharmacol. Ther. (1998) [Pubmed]
  8. Tamoxifen effects on subjective and psychosexual well-being, in a randomised breast cancer study comparing high-dose and standard-dose chemotherapy. Mourits, M.J., Böckermann, I., de Vries, E.G., van der Zee, A.G., ten Hoor, K.A., van der Graaf, W.T., Sluiter, W.J., Willemse, P.H. Br. J. Cancer (2002) [Pubmed]
  9. The effects of tibolone on mood and libido. Davis, S.R. Menopause (New York, N.Y.) (2002) [Pubmed]
  10. A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Vercellini, P., Trespidi, L., Colombo, A., Vendola, N., Marchini, M., Crosignani, P.G. Fertil. Steril. (1993) [Pubmed]
  11. Regression of uterine leiomyomas after treatment with gestrinone, an antiestrogen, antiprogesterone. Coutinho, E.M., Boulanger, G.A., Gonçalves, M.T. Am. J. Obstet. Gynecol. (1986) [Pubmed]
  12. Sildenafil improves sexual functioning in premenopausal women with type 1 diabetes who are affected by sexual arousal disorder: a double-blind, crossover, placebo-controlled pilot study. Caruso, S., Rugolo, S., Agnello, C., Intelisano, G., Di Mari, L., Cianci, A. Fertil. Steril. (2006) [Pubmed]
  13. Laparoscopic findings in women with chronic pelvic pain. Newham, A.P., van der Spuy, Z.M., Nugent, F. S. Afr. Med. J. (1996) [Pubmed]
  14. The Ipswich childbirth study: one year follow up of alternative methods used in perineal repair. Grant, A., Gordon, B., Mackrodat, C., Fern, E., Truesdale, A., Ayers, S. BJOG : an international journal of obstetrics and gynaecology. (2001) [Pubmed]
  15. Safety and efficacy of topical nitroglycerin for treatment of vulvar pain in women with vulvodynia: a pilot study. Walsh, K.E., Berman, J.R., Berman, L.A., Vierregger, K. The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia. (2002) [Pubmed]
  16. Cutaneous and subcutaneous endometriosis. Surgical and hormonal therapy. Purvis, R.S., Tyring, S.K. The Journal of dermatologic surgery and oncology. (1994) [Pubmed]
  17. The effects of postmenopausal hormone therapies on female sexual functioning: a review of double-blind, randomized controlled trials. Alexander, J.L., Kotz, K., Dennerstein, L., Kutner, S.J., Wallen, K., Notelovitz, M. Menopause (New York, N.Y.) (2004) [Pubmed]
  18. Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients. Morales, L., Neven, P., Timmerman, D., Christiaens, M.R., Vergote, I., Van Limbergen, E., Carbonez, A., Van Huffel, S., Ameye, L., Paridaens, R. Anticancer Drugs (2004) [Pubmed]
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