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MeSH Review


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Disease relevance of Osteoporosis


High impact information on Osteoporosis

  • Thus, both sex steroids are important for developing peak bone mass, but E deficiency is the major determinant of age-related bone loss in both sexes [6].
  • Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss [1].
  • IL-11 may be a new therapeutic target for senile osteoporosis [7].
  • CONCLUSIONS: Supplementing the diet of men >50 years of age with reduced-fat calcium- and vitamin D3-enriched milk may represent a simple, nutritionally sound and cost-effective strategy to reduce age-related bone loss at several skeletal sites at risk for fracture in the elderly [8].
  • MATERIALS AND METHODS: We explored the possibility that the TNSALP gene may contribute to age-related bone loss in humans by examining the association between TNSALP gene polymorphisms and BMD in 501 Japanese postmenopausal women [9].

Chemical compound and disease context of Osteoporosis


Anatomical context of Osteoporosis


Gene context of Osteoporosis

  • Although the large age-related increase in serum IL-6 concentration could contribute to age-related bone loss, the lack of correlation with markers for bone turnover argues against this [17].
  • Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice [18].
  • These findings indicate that age-related bone loss in humans is associated with a decrease in the osteoblastic secretion of both PTHrP and VEGF in the knee, a predominantly trabecular bone [19].
  • Because the value of calcium supplementation in age-related bone loss is controversial, we conducted a study to examine the effects of six months of calcium supplementation on parathyroid hormone (PTH) and other indices of bone metabolism [20].
  • CONCLUSIONS: These results suggest that variation in TNSALP may be an important determinant of age-related bone loss in humans and that the phosphate metabolism pathway may provide a novel target for the prevention and treatment of osteoporosis [9].

Analytical, diagnostic and therapeutic context of Osteoporosis


  1. Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss. Delmas, P.D., Stenner, D., Wahner, H.W., Mann, K.G., Riggs, B.L. J. Clin. Invest. (1983) [Pubmed]
  2. Effects of vitamin D2 analogs on calcium metabolism in vitamin D-deficient rats and in MC3T3-E1 osteoblastic cells. Sato, F., Ouchi, Y., Okamoto, Y., Kaneki, M., Nakamura, T., Ikekawa, N., Orimo, H. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1991) [Pubmed]
  3. Animal models of immobilization osteopenia. Jee, W.S., Ma, Y. Morphologie : bulletin de l'Association des anatomistes. (1999) [Pubmed]
  4. The contribution of nutritional factors to osteopenia in the elderly. Sahota, O., Hosking, D.J. Current opinion in clinical nutrition and metabolic care. (2001) [Pubmed]
  5. The aetiology of senile osteoporosis: secondary hyperparathyroidism due to renal failure. Berlyne, G.M., Ben-Ari, J., Kushelevsky, A., Idelman, A., Galinsky, D., Hirsch, M., Shainkin, R., Yagil, R., Zlotnik, M. Q. J. Med. (1975) [Pubmed]
  6. Sex steroids and the construction and conservation of the adult skeleton. Riggs, B.L., Khosla, S., Melton, L.J. Endocr. Rev. (2002) [Pubmed]
  7. Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. Takeuchi, Y., Watanabe, S., Ishii, G., Takeda, S., Nakayama, K., Fukumoto, S., Kaneta, Y., Inoue, D., Matsumoto, T., Harigaya, K., Fujita, T. J. Biol. Chem. (2002) [Pubmed]
  8. Calcium- and vitamin D3-fortified milk reduces bone loss at clinically relevant skeletal sites in older men: a 2-year randomized controlled trial. Daly, R.M., Brown, M., Bass, S., Kukuljan, S., Nowson, C. J. Bone Miner. Res. (2006) [Pubmed]
  9. Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD. Goseki-Sone, M., Sogabe, N., Fukushi-Irie, M., Mizoi, L., Orimo, H., Suzuki, T., Nakamura, H., Orimo, H., Hosoi, T. J. Bone Miner. Res. (2005) [Pubmed]
  10. Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. Greendale, G.A., Edelstein, S., Barrett-Connor, E. J. Bone Miner. Res. (1997) [Pubmed]
  11. Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis. Li, C.Y., Price, C., Delisser, K., Nasser, P., Laudier, D., Clement, M., Jepsen, K.J., Schaffler, M.B. J. Bone Miner. Res. (2005) [Pubmed]
  12. Histomorphometric effects of calcium or calcium plus 25-hydroxyvitamin D3 therapy in senile osteoporosis. Orwoll, E.S., McClung, M.R., Oviatt, S.K., Recker, R.R., Weigel, R.M. J. Bone Miner. Res. (1989) [Pubmed]
  13. Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. Gallagher, J.C., Fowler, S.E., Detter, J.R., Sherman, S.S. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  14. Site-specific effects of cerivastatin on bone in male Sprague-Dawley rats. Banu, J., Kalu, D.N. Bone (2004) [Pubmed]
  15. Effects of cerivastatin and parathyroid hormone on the lumbar vertebra of aging male Sprague-Dawley rats. Banu, J., Kalu, D.N. Bone (2002) [Pubmed]
  16. L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro. Colucci, S., Mori, G., Vaira, S., Brunetti, G., Greco, G., Mancini, L., Simone, G.M., Sardelli, F., Koverech, A., Zallone, A., Grano, M. Calcif. Tissue Int. (2005) [Pubmed]
  17. Circulating levels of cytokines that modulate bone resorption: effects of age and menopause in women. McKane, W.R., Khosla, S., Peterson, J.M., Egan, K., Riggs, B.L. J. Bone Miner. Res. (1994) [Pubmed]
  18. Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice. Cao, J., Venton, L., Sakata, T., Halloran, B.P. J. Bone Miner. Res. (2003) [Pubmed]
  19. Age-related changes in parathyroid hormone-related protein and vascular endothelial growth factor in human osteoblastic cells. Martínez, P., Esbrit, P., Rodrigo, A., Alvarez-Arroyo, M.V., Martínez, M.E. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2002) [Pubmed]
  20. The metabolic effects of calcium supplementation in the elderly. Kochersberger, G., Westlund, R., Lyles, K.W. Journal of the American Geriatrics Society. (1991) [Pubmed]
  21. Calcium supplementation lowers serum parathyroid hormone levels in elderly subjects. Kochersberger, G., Bales, C., Lobaugh, B., Lyles, K.W. Journal of gerontology. (1990) [Pubmed]
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