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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Diaphyses

  • Schwartz-Jampel syndrome (SJS1) is a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses [1].
  • Histomorphometry was performed on periosteal and endocortical surfaces of the tibial diaphysis in all groups. microCT of tibias and mechanical testing by torsion of femora were performed on 28d-PTH and 7d-PTH/21d-WD animals [2].
  • Bone to soft tissue (ST) ratios for both high-uptake bone (sacrum) and low-uptake bone (femoral diaphysis) were obtained with a derivative of phosphonic acid, TC-99m 2,3-dicarboxypropane-1, 1-diphosphonate (DPD), in 26 normal subjects and 177 patients with malignant disease but without metastases [3].
  • Zircalloy 4 metallic cones (1.8 mm base x 2 mm height) were implanted in the diaphysis of the tibiae of 6 Wistar rats (90 g body weight) under i.p. Ethyl Urethane anesthesia [4].

Psychiatry related information on Diaphyses


High impact information on Diaphyses

  • Camurati-Engelmann disease (CED, MIM 131300) is an autosomal dominant, progressive diaphyseal dysplasia characterized by hyperosteosis and sclerosis of the diaphyses of long bones [6].
  • In turn, FLT-1 neutralization affects leukemia localization (now in the BM diaphysis), increases leukemia apoptosis, and impedes the exit of ALL cells, prolonging the survival of inoculated mice [7].
  • Holes were drilled transversely through the diaphysis of both tibiae of PAR-1-null and wild-type mice [8].
  • Parathyroid hormone rapidly stimulates hyaluronan synthesis by periosteal osteoblasts in the tibial diaphysis of the growing rat [9].
  • ICF increased the amount of incorporated sulfate per tissue volume unit in the noncalcified epiphyses, but decreased this parameter in the calcified diaphysis [10].

Chemical compound and disease context of Diaphyses

  • Following training, right tibiae and femora were tested to failure in torsion at 180 degrees/s. Sections were cut from the distal, mid and proximal diaphysis of left bones, bulk-stained in basic fuchsin and two transverse sections (50 microns) were cut and examined for the presence of microdamage and fluorescence [11].

Biological context of Diaphyses


Anatomical context of Diaphyses


Associations of Diaphyses with chemical compounds

  • Distal femora of normal dogs were transected at the diaphysis and incubated in medium containing sodium salicylate or indomethacin and 35SO4 [22].
  • Only in the bhGH-80-day group was subperiosteal tetracycline double labeling seen all around the femur diaphysis, and this pattern was found in all animals of the group [23].
  • Treatment with pamidronate increased the total BMD as well as that of the metaphysis of the femur but had almost no effect on the BMD of the diaphysis in both control and tail-suspended rats [24].
  • We sought to determine whether risedronate can preserve cortical bone mass and mechanical properties during long-term disuse in dogs, assessed by histomorphometry and biomechanics on metacarpal diaphyses [25].
  • In agreement with the changes in the BMD of different regions of the femur, TZP-4238 but not E2 increased the physical strength of the femoral diaphysis assessed by a three-point bending test [26].

Gene context of Diaphyses

  • FGFR1 is preferentially expressed in the diaphyses, whereas FGFR2-Bek expression characterizes metaphyseal and diaphyseal elements, and the interdigital mesenchyme [27].
  • SDF-1 staining was generally low or undetectable in the center of the marrow and in the diaphysis [28].
  • Versican mRNA expression rapidly disappeared from the tibial cartilage, as cartilage formation progressed during E13-15, but the immunostaining was gradually replaced by aggrecan immunostaining from the diaphysis [29].
  • DAT (-/-) vertebrae have lower cancellous bone volume as a consequence of increased trabecular spacing and reduced trabecular number, and cortical thickness and bone area in the femoral diaphysis are reduced [30].
  • Finally, it was observed that the lining cells along the endosteal surface of the diaphysis did not stain strongly positive for HyA either naturally or when exposed to PTH treatment [9].

Analytical, diagnostic and therapeutic context of Diaphyses


  1. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). Nicole, S., Davoine, C.S., Topaloglu, H., Cattolico, L., Barral, D., Beighton, P., Hamida, C.B., Hammouda, H., Cruaud, C., White, P.S., Samson, D., Urtizberea, J.A., Lehmann-Horn, F., Weissenbach, J., Hentati, F., Fontaine, B. Nat. Genet. (2000) [Pubmed]
  2. Continuous parathyroid hormone induces cortical porosity in the rat: effects on bone turnover and mechanical properties. Lotinun, S., Evans, G.L., Bronk, J.T., Bolander, M.E., Wronski, T.J., Ritman, E.L., Turner, R.T. J. Bone Miner. Res. (2004) [Pubmed]
  3. A comparison of bone imaging with Tc-99m DPD and Tc-99m MDP: concise communication. Buell, U., Kleinhans, E., Zorn-Bopp, E., Reuschel, W., Muenzing, W., Moser, E.A., Seiderer, M. J. Nucl. Med. (1982) [Pubmed]
  4. A method for the quality control of osseointegration in endosseous implants. Almagro, J.C., Guglielmotti, M.B., Cabrini, R.L., Todarello, A. Acta odontológica latinoamericana : AOL. (1994) [Pubmed]
  5. Physical activity as a determinant of bone conservation in the radial diaphysis in rheumatoid arthritis. Shawe, D., Hesp, R., Gumpel, J.M., Sambrook, P.N., Reeve, J. Ann. Rheum. Dis. (1993) [Pubmed]
  6. Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Kinoshita, A., Saito, T., Tomita, H., Makita, Y., Yoshida, K., Ghadami, M., Yamada, K., Kondo, S., Ikegawa, S., Nishimura, G., Fukushima, Y., Nakagomi, T., Saito, H., Sugimoto, T., Kamegaya, M., Hisa, K., Murray, J.C., Taniguchi, N., Niikawa, N., Yoshiura, K. Nat. Genet. (2000) [Pubmed]
  7. VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease. Fragoso, R., Pereira, T., Wu, Y., Zhu, Z., Cabeçadas, J., Dias, S. Blood (2006) [Pubmed]
  8. The role of protease-activated receptor-1 in bone healing. Song, S.J., Pagel, C.N., Campbell, T.M., Pike, R.N., Mackie, E.J. Am. J. Pathol. (2005) [Pubmed]
  9. Parathyroid hormone rapidly stimulates hyaluronan synthesis by periosteal osteoblasts in the tibial diaphysis of the growing rat. Midura, R.J., Su, X., Morcuende, J.A., Tammi, M., Tammi, R. J. Biol. Chem. (2003) [Pubmed]
  10. Influence of intermittent compressive force on proteoglycan content in calcifying growth plate cartilage in vitro. Klein-Nulend, J., Veldhuijzen, J.P., van de Stadt, R.J., van Kampen, G.P., Kuijer, R., Burger, E.H. J. Biol. Chem. (1987) [Pubmed]
  11. Repetitive loading, in vivo, of the tibiae and femora of rats: effects of repeated bouts of treadmill-running. Forwood, M.R., Parker, A.W. Bone and mineral. (1991) [Pubmed]
  12. Estrogen inhibition of periosteal bone formation in rat long bones: down-regulation of gene expression for bone matrix proteins. Turner, R.T., Colvard, D.S., Spelsberg, T.C. Endocrinology (1990) [Pubmed]
  13. Retardation in bone resorption after bone marrow ablation in klotho mutant mice. Yamashita, T., Yoshitake, H., Tsuji, K., Kawaguchi, N., Nabeshima, Y., Noda, M. Endocrinology (2000) [Pubmed]
  14. Differences in size at birth are determined by differences in growth velocity during early prenatal life. Milani, S., Bossi, A., Bertino, E., di Battista, E., Coscia, A., Aicardi, G., Fabris, C., Benso, L. Pediatr. Res. (2005) [Pubmed]
  15. Phenytoin-induced bone loss and its prevention with alfacalcidol or calcitriol in growing rats. Onodera, K., Takahashi, A., Mayanagi, H., Wakabayashi, H., Kamei, J., Shinoda, H. Calcif. Tissue Int. (2001) [Pubmed]
  16. The collagen crosslinking in the hypophosphatemic male mouse. van der Rest, M., de Miguel, E., Glorieux, F.H. Calcif. Tissue Int. (1981) [Pubmed]
  17. The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. Freitas, F.R., Capelo, L.P., O'Shea, P.J., Jorgetti, V., Moriscot, A.S., Scanlan, T.S., Williams, G.R., Zorn, T.M., Gouveia, C.H. J. Bone Miner. Res. (2005) [Pubmed]
  18. Clodronate prevents osteopenia and loss of trabecular connectivity in estrogen-deficient rats. Kippo, K., Hannuniemi, R., Isaksson, P., Laurén, L., Osterman, T., Peng, Z., Tuukkanen, J., Kuurtamo, P., Väänänen, H.K., Sellman, R. J. Bone Miner. Res. (1998) [Pubmed]
  19. Osteopenia and bone-remodeling abnormalities in warfarin-treated lambs. Pastoureau, P., Vergnaud, P., Meunier, P.J., Delmas, P.D. J. Bone Miner. Res. (1993) [Pubmed]
  20. Regional variation of insulin-like growth factor-I gene expression in mature rat bone and cartilage. Lazowski, D.A., Fraher, L.J., Hodsman, A., Steer, B., Modrowski, D., Han, V.K. Bone (1994) [Pubmed]
  21. Expression of syndecan-3 and tenascin-C: possible involvement in periosteum development. Koyama, E., Shimazu, A., Leatherman, J.L., Golden, E.B., Nah, H.D., Pacifici, M. J. Orthop. Res. (1996) [Pubmed]
  22. Effects of salicylate and indomethacin on glycosaminoglycan and prostaglandin E2 synthesis in intact canine knee cartilage ex vivo. Palmoski, M.J., Brandt, K.D. Arthritis Rheum. (1984) [Pubmed]
  23. Growth hormone stimulates bone formation and strength of cortical bone in aged rats. Andreassen, T.T., Jørgensen, P.H., Flyvbjerg, A., Orskov, H., Oxlund, H. J. Bone Miner. Res. (1995) [Pubmed]
  24. Inhibition of bone resorption by pamidronate cannot restore normal gain in cortical bone mass and strength in tail-suspended rapidly growing rats. Kodama, Y., Nakayama, K., Fuse, H., Fukumoto, S., Kawahara, H., Takahashi, H., Kurokawa, T., Sekiguchi, C., Nakamura, T., Matsumoto, T. J. Bone Miner. Res. (1997) [Pubmed]
  25. Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis. Li, C.Y., Price, C., Delisser, K., Nasser, P., Laudier, D., Clement, M., Jepsen, K.J., Schaffler, M.B. J. Bone Miner. Res. (2005) [Pubmed]
  26. A new synthetic steroid, osaterone acetate (TZP-4238), increases cortical bone mass and strength by enhancing bone formation in ovariectomized rats. Fuse, H., Fukumoto, S., Sone, H., Miyata, Y., Saito, T., Nakayama, K., Takahashi, H., Matsumoto, T., Ogata, E. J. Bone Miner. Res. (1997) [Pubmed]
  27. Differential expression of fibroblast growth factor receptors in human digital development suggests common pathogenesis in complex acrosyndactyly and craniosynostosis. Britto, J.A., Chan, J.C., Evans, R.D., Hayward, R.D., Jones, B.M. Plast. Reconstr. Surg. (2001) [Pubmed]
  28. Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. Sun, Y.X., Schneider, A., Jung, Y., Wang, J., Dai, J., Wang, J., Cook, K., Osman, N.I., Koh-Paige, A.J., Shim, H., Pienta, K.J., Keller, E.T., McCauley, L.K., Taichman, R.S. J. Bone Miner. Res. (2005) [Pubmed]
  29. In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage. Shibata, S., Fukada, K., Imai, H., Abe, T., Yamashita, Y. J. Anat. (2003) [Pubmed]
  30. The role of dopamine and serotonin in regulating bone mass and strength: studies on dopamine and serotonin transporter null mice. Bliziotes, M., Gunness, M., Eshleman, A., Wiren, K. Journal of musculoskeletal & neuronal interactions. (2002) [Pubmed]
  31. Differential effects of gonadal function on bone histomorphometry in male and female rats. Turner, R.T., Hannon, K.S., Demers, L.M., Buchanan, J., Bell, N.H. J. Bone Miner. Res. (1989) [Pubmed]
  32. Blood perfusion and remodelling activity in canine tibial diaphysis after filling with a new bone cement compared to bone wax and poly(methyl methacrylate) cement. Stürup, J., Nimb, L., Jensen, J.S. Biomaterials (1995) [Pubmed]
  33. Oral administration of calcium hydroxide stimulates bone metabolism in the femoral diaphysis of rats with skeletal unloading. Yamaguchi, M., Shimokawa, N., Hoshi, T. Chem. Pharm. Bull. (1991) [Pubmed]
  34. Allogenic vascularized transplantation of a human femoral diaphysis under cyclosporin A immunosuppression. Hofmann, G.O., Kirschner, M.H., Bühren, V., Land, W. Transpl. Int. (1995) [Pubmed]
  35. The reversed Delta shoulder prosthesis in reconstruction of the proximal humerus after tumour resection. De Wilde, L., Sys, G., Julien, Y., Van Ovost, E., Poffyn, B., Trouilloud, P. Acta orthopaedica Belgica. (2003) [Pubmed]
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