Psychiatry related information on Hypochondriasis

• Given marked similarities between hypochondriasis and obsessive-compulsive disorder, we decided to conduct an open trial of high-dose fluoxetine for patients with DSM-III-R hypochondriasis who did not meet criteria for major depression [1].
• Eight clinical scales (hypochondriasis, depression, hysteria, psychopathic deviate, paranoia, psychasthenia, schizophrenia, and hypomania) as well as cortisol level, CD3, CD4, CD8, and CD16 markers by group were compared [2].
• In the patients an association was observed between the 2/2 5HTR2A genotype and scores on the Hypochondriasis scale (MMPI) (ANOVA, F = 4.56; P = 0.011) and trait anxiety (F = 4.21; P = 0.002) [3].
• They originally presented as psychiatric disorders, such as hysterical neurosis, epilepsy, anorexia nervosa and hypochondriacal neurosis [4].
• No significant differences were observed for all PES items, although sulpiride was found more effective for hypochondriasis and neurotic complaint as was bromperidol for hallucination and disturbance of self-conscious [5].

High impact information on Hypochondriasis

• CONCLUSION: These findings suggest that a subgroup of patients with hypochondriasis may be particularly responsive to serotonin reuptake blockers [6].
• In 25 Jewish and 26 non-Jewish depressives resident in Hackney, the PSE revealed that 'hypochondriasis' and 'tension' were more common in the Jewish group, and special features of depression, containing symptoms connected with guilt, was less common [7].
• CONCLUSION: Even though the ICD-10-defined hypochondriasis is rare, a form consisting of the triad of disease conviction, associated distress and medical help-seeking is present in primary-care settings in different cultures [8].
• Panic disorder was frequently preceded by (and associated with) generalized anxiety, phobic avoidance and hypochondriasis [9].
• The group with RA was found to be significantly different from the normal group on hypochondriasis and pain tolerance [10].

Chemical compound and disease context of Hypochondriasis

• The purpose of the present study was to evaluate the use of nefazodone in the treatment of hypochondriasis in an open-label trial [11].
• An open study of paroxetine in hypochondriasis [12].
• An open trial of fluvoxamine for hypochondriasis [13].
• The following data were collected: salivary cortisol at three time points (morning, afternoon, evening), nighttime urinary cortisol, serum cortisol after the dexamethasone suppression test (DST), and psychological variables such as depression, anxiety, somatization, and hypochondriasis [14].
• METHOD: In January 1995, 166 first-year students at the University of Illinois College of Medicine were shown a videotape of six patients vignettes illustrating three types of patient behaviors (anger, seduction, and hypochondriasis) by pairs of men and women [15].

Gene context of Hypochondriasis

• Dr. William Cullen and Mr. Adam Smith: a case of hypochondriasis [16]?
• Modest correlations were observed between hypochondriasis and symptoms of panic and major depressive disorder, but in depressed patients, hypochondriasis was positively correlated with anxiety symptoms as well [17].
• We found no relationship between internal locus of control, hypochondriasis, and loneliness, on the one hand, and cancer knowledge and SE, on the other [18].

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