Disease relevance of Anus Neoplasms

• Specimens of anal-cancer tissue and samples of rectal adenocarcinomas were tested for human papillomavirus (HPV) DNA with the polymerase chain reaction [1].
• In this study, our purpose was to determine the incidence of mutant P53 and HPV-16 and 18-related E6 protein and their coexpression in anal cancers [2].
• Increased survival of CD1 mice bearing dimethylhydrazine induced primary colon and anal cancers by difluoromethylornithine with concomitant increase in angiosarcoma incidence [3].

High impact information on Anus Neoplasms

• According to more recent data from the literature, primary CRT is the elective indication in epidermoid cancer of the anus and replacement of MMC with CDDP seems an effective and logical evolution [4].
• Anal cancer. American College of Radiology. ACR Appropriateness Criteria [5].
• Sera from 64 patients with anal cancer and from 79 healthy blood donors were studied in ELISA for the presence of IgA and IgG antibodies to 5 previously described HPV16-derived synthetic peptide antigens [6].
• The CRT regimen described here provides the basis for the 'control arm' of the current UK-randomised CRT trial in anal cancer (ACT2) [7].
• The median CD4 count at diagnosis of anal cancer was 209 cells/microl (range: 29-380 cells/microl), 5 had prior AIDS defining diagnoses [8].

Chemical compound and disease context of Anus Neoplasms

• Interstitial iridium-192 implantation combined with external radiotherapy in anal cancer: ten years experience [9].
• Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cisplatin [10].
• Although not yet included in the Centers for Disease Control definition of AIDS, anal cancer clearly occurs more commonly in HIV-infected patients [11].
• METHODS: A combination of radio-labelled Antimony Sulphide and Patent Blue dye injected around the anal cancer enable identification of the sentinel node in the groin, using a gamma probe and direct visualization of the blue node [12].

Biological context of Anus Neoplasms

• Our data strongly suggest that persons with the GSTM1-null genotype are not at increased risk of anal cancer, and may well be at a decreased risk [13].

Anatomical context of Anus Neoplasms

• Prospective and randomized studies of 5-FU-based chemoradiation are under way in esophageal, gastric, biliary tract, pancreatic, rectal, and anal cancer [14].

Gene context of Anus Neoplasms

• Proliferation and p53 expression in anal cancer precursor lesions [15].
• This first report of expression of ESE-1, and of SPRR2A and ENDOA/CK8 (both related to terminal differentiation in different types of epithelia lining) in anal cancer excludes the hypothesis that these genes influenced carcinogenesis in our patients [16].
• The association with lymphatic/hematopoietic cancers may indicate a possible role for immunodeficiency in anal cancer development [17].
• Immunohistochemical detection of mutant P53 protein and human papillomavirus-related E6 protein in anal cancers [2].
• This study evaluates anorectal function after combined tele- and brachytherapy for anal cancer using manometric measurements and a standardized questionnaire [18].

Analytical, diagnostic and therapeutic context of Anus Neoplasms

• Glutathione S-transferase M1 genotypes and the risk of anal cancer: a population-based case-control study [13].

References