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MeSH Review

Anus Neoplasms

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Disease relevance of Anus Neoplasms


High impact information on Anus Neoplasms

  • According to more recent data from the literature, primary CRT is the elective indication in epidermoid cancer of the anus and replacement of MMC with CDDP seems an effective and logical evolution [4].
  • Anal cancer. American College of Radiology. ACR Appropriateness Criteria [5].
  • Sera from 64 patients with anal cancer and from 79 healthy blood donors were studied in ELISA for the presence of IgA and IgG antibodies to 5 previously described HPV16-derived synthetic peptide antigens [6].
  • The CRT regimen described here provides the basis for the 'control arm' of the current UK-randomised CRT trial in anal cancer (ACT2) [7].
  • The median CD4 count at diagnosis of anal cancer was 209 cells/microl (range: 29-380 cells/microl), 5 had prior AIDS defining diagnoses [8].

Chemical compound and disease context of Anus Neoplasms


Biological context of Anus Neoplasms

  • Our data strongly suggest that persons with the GSTM1-null genotype are not at increased risk of anal cancer, and may well be at a decreased risk [13].

Anatomical context of Anus Neoplasms


Gene context of Anus Neoplasms

  • Proliferation and p53 expression in anal cancer precursor lesions [15].
  • This first report of expression of ESE-1, and of SPRR2A and ENDOA/CK8 (both related to terminal differentiation in different types of epithelia lining) in anal cancer excludes the hypothesis that these genes influenced carcinogenesis in our patients [16].
  • The association with lymphatic/hematopoietic cancers may indicate a possible role for immunodeficiency in anal cancer development [17].
  • Immunohistochemical detection of mutant P53 protein and human papillomavirus-related E6 protein in anal cancers [2].
  • This study evaluates anorectal function after combined tele- and brachytherapy for anal cancer using manometric measurements and a standardized questionnaire [18].

Analytical, diagnostic and therapeutic context of Anus Neoplasms


  1. Sexually transmitted infection as a cause of anal cancer. Frisch, M., Glimelius, B., van den Brule, A.J., Wohlfahrt, J., Meijer, C.J., Walboomers, J.M., Goldman, S., Svensson, C., Adami, H.O., Melbye, M. N. Engl. J. Med. (1997) [Pubmed]
  2. Immunohistochemical detection of mutant P53 protein and human papillomavirus-related E6 protein in anal cancers. Jakate, S.M., Saclarides, T.J. Dis. Colon Rectum (1993) [Pubmed]
  3. Increased survival of CD1 mice bearing dimethylhydrazine induced primary colon and anal cancers by difluoromethylornithine with concomitant increase in angiosarcoma incidence. Benrezzak, O., Nigam, V.N., Madarnas, P. Anticancer Res. (1987) [Pubmed]
  4. Primary chemoradiation therapy with fluorouracil and cisplatin for cancer of the anus: results in 35 consecutive patients. Doci, R., Zucali, R., La Monica, G., Meroni, E., Kenda, R., Eboli, M., Lozza, L. J. Clin. Oncol. (1996) [Pubmed]
  5. Anal cancer. American College of Radiology. ACR Appropriateness Criteria. John, M.J., Merrick, G.S., Coia, L.R., Minsky, B.D., Bader, J.L., Janjan, N.A., Raben, D., Rich, T.A., Rosenthal, S.A., Tepper, J.E., Ota, D., Saltz, L., Leibel, S. Radiology. (2000) [Pubmed]
  6. Molecular and serological studies of human papillomavirus among patients with anal epidermoid carcinoma. Heino, P., Goldman, S., Lagerstedt, U., Dillner, J. Int. J. Cancer (1993) [Pubmed]
  7. Concurrent chemoradiotherapy for squamous cell carcinoma of the anus using a shrinking field radiotherapy technique without a boost. Melcher, A.A., Sebag-Montefiore, D. Br. J. Cancer (2003) [Pubmed]
  8. Treatment of HIV-associated invasive anal cancer with combined chemoradiation. Cleator, S., Fife, K., Nelson, M., Gazzard, B., Phillips, R., Bower, M. Eur. J. Cancer (2000) [Pubmed]
  9. Interstitial iridium-192 implantation combined with external radiotherapy in anal cancer: ten years experience. Sandhu, A.P., Symonds, R.P., Robertson, A.G., Reed, N.S., McNee, S.G., Paul, J. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  10. Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cisplatin. Rich, T.A., Ajani, J.A., Morrison, W.H., Ota, D., Levin, B. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1993) [Pubmed]
  11. Anal cancer: an HIV-associated cancer. Klencke, B.J., Palefsky, J.M. Hematol. Oncol. Clin. North Am. (2003) [Pubmed]
  12. Sentinel lymph node biopsy for squamous cell carcinoma of the anal canal. Rabbitt, P., Pathma-Nathan, N., Collinson, T., Hewett, P., Rieger, N. ANZ journal of surgery. (2002) [Pubmed]
  13. Glutathione S-transferase M1 genotypes and the risk of anal cancer: a population-based case-control study. Chen, C., Madeleine, M.M., Lubinski, C., Weiss, N.S., Tickman, E.W., Daling, J.R. Cancer Epidemiol. Biomarkers Prev. (1996) [Pubmed]
  14. Capecitabine and radiation therapy for advanced gastrointestinal malignancies. Rich, T. Oncology (Williston Park, N.Y.) (2002) [Pubmed]
  15. Proliferation and p53 expression in anal cancer precursor lesions. Mullerat, J., Deroide, F., Winslet, M.C., Perrett, C.W. Anticancer Res. (2003) [Pubmed]
  16. Expression analysis and mutational screening of the epithelium-specific ets gene-1 (ESE-1) in patients with squamous anal cancer. Zucchini, C., Strippoli, P., Rosati, G., Del Governatore, M., Milano, E., Ugolini, G., Solmi, R., Mattei, G., Caira, A., Zanotti, S., Carinci, P., Valvassori, L. Int. J. Oncol. (2000) [Pubmed]
  17. Malignancies that occur before and after anal cancer: clues to their etiology. Frisch, M., Olsen, J.H., Melbye, M. Am. J. Epidemiol. (1994) [Pubmed]
  18. Clinical and manometric effects of combined external beam irradiation and brachytherapy for anal cancer. Broens, P., Van Limbergen, E., Penninckx, F., Kerremans, R. International journal of colorectal disease. (1998) [Pubmed]
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