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Chemical Compound Review

Sulphanblau     sodium4-[(4- diethylaminophenyl)-(4...

Synonyms: Alphazurine 2G, ALPHAZURIN 2G, Disulphine VN, L-Blau 3, Disulphen Blau, ...
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Disease relevance of [4-[(4-diethylaminophenyl)-(2,4-disulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-diethyl-azanium


High impact information on [4-[(4-diethylaminophenyl)-(2,4-disulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-diethyl-azanium


Biological context of [4-[(4-diethylaminophenyl)-(2,4-disulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-diethyl-azanium

  • No demonstrable loss of accuracy was caused by skin pigmentation, the concurrent administration of low doses of dopamine or vasodilators, or the intra-operative intravascular administration of Patent Blue V dye [11].
  • The permeation properties of five MDR modulators were therefore studied at 37 degrees C by quantifying their ability to induce the leakage of Sulfan blue through unilamellar anionic liposomes, over the range pH 6.5-7.7, and in the absence of any membrane potential (pHe = pHi) [12].
  • In the rest Patent Blue Violet and not Lipoodol was used to minimize any spurious effect on node histology [13].

Anatomical context of [4-[(4-diethylaminophenyl)-(2,4-disulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-diethyl-azanium


Associations of [4-[(4-diethylaminophenyl)-(2,4-disulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-diethyl-azanium with other chemical compounds


Gene context of [4-[(4-diethylaminophenyl)-(2,4-disulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-diethyl-azanium

  • We investigated the feasibility of in vivo SLN detection with Patent Blue V dye and evaluated nodal microstaging and ultrastaging using cytokeratin immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) [23].
  • In a subset of 153 patients, both vital blue dye (Patent Blue-V) lymphatic mapping and RGS were used to identify the sN, and the relative contribution of each of the two techniques was assessed [24].
  • The permeation properties of MDR-modulators and non-modulators were studied by quantifying their ability to induce the leakage of Sulphan blue through the membrane of negatively charged unilamellar liposomes [25].
  • SLN biopsy was performed using a combination of Patent blue V and 99mTc-radiolabelled colloidal albumin injected peritumourally [26].
  • Patent blue assisted staining of the retinal surface followed by a consecutive peeling of the ERM (n = 4) or of the internal limiting membrane (ILM; n = 1) was performed [27].

Analytical, diagnostic and therapeutic context of [4-[(4-diethylaminophenyl)-(2,4-disulfophenyl)methylidene]-1-cyclohexa-2,5-dienylidene]-diethyl-azanium


  1. Halsted revisited: internal mammary sentinel lymph node biopsy in breast cancer. van der Ent, F.W., Kengen, R.A., van der Pol, H.A., Povel, J.A., Stroeken, H.J., Hoofwijk, A.G. Ann. Surg. (2001) [Pubmed]
  2. Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction. Lukowsky, A., Bellmann, B., Ringk, A., Winter, H., Audring, H., Fenske, S., Sterry, W. J. Invest. Dermatol. (1999) [Pubmed]
  3. Epinephrine enhances penetration and anti-cancer activity of local cisplatin on rat sub-cutaneous and peritoneal tumors. Duvillard, C., Benoit, L., Moretto, P., Beltramo, J.L., Brunet-Lecomte, P., Correia, M., Sergent, C., Chauffert, B. Int. J. Cancer (1999) [Pubmed]
  4. Near-fatal anaphylaxis to patent blue V. Wöhrl, S., Focke, M., Hinterhuber, G., Stingl, G., Binder, M. Br. J. Dermatol. (2004) [Pubmed]
  5. Anaphylaxis to isosulfan blue and cross-reactivity to patent blue V: case report and review of the nomenclature of vital blue dyes. Scherer, K., Studer, W., Figueiredo, V., Bircher, A.J. Ann. Allergy Asthma Immunol. (2006) [Pubmed]
  6. Reduced tumor oxygenation by treatment with vinblastine. Sersa, G., Krzic, M., Sentjurc, M., Ivanusa, T., Beravs, K., Cemazar, M., Auersperg, M., Swartz, H.M. Cancer Res. (2001) [Pubmed]
  7. Fluid uptake from the renal medulla into the ascending vasa recta in anaesthetized rats. MacPhee, P.J., Michel, C.C. J. Physiol. (Lond.) (1995) [Pubmed]
  8. Value of the sentinel lymph node procedure in patients with large size breast cancer. Lelievre, L., Houvenaeghel, G., Buttarelli, M., Brenot-Rossi, I., Huiart, L., Tallet, A., Tarpin, C., Jacquemier, J. Ann. Surg. Oncol. (2007) [Pubmed]
  9. 99mTc-Evans blue dye for mapping contiguous lymph node sequences and discriminating the sentinel lymph node in an ovine model. Tsopelas, C., Bevington, E., Kollias, J., Shibli, S., Farshid, G., Coventry, B., Chatterton, B.E. Ann. Surg. Oncol. (2006) [Pubmed]
  10. Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin. Sersa, G., Krzic, M., Sentjurc, M., Ivanusa, T., Beravs, K., Kotnik, V., Coer, A., Swartz, H.M., Cemazar, M. Br. J. Cancer (2002) [Pubmed]
  11. Pulse oximetry and postoperative hypothermia. An evaluation of the Nellcor N-100 in a cardiac surgical intensive care unit. Gabrielczyk, M.R., Buist, R.J. Anaesthesia. (1988) [Pubmed]
  12. Designing multidrug-resistance modulators circumventing the reverse pH gradient in tumours. Castaing, M., Loiseau, A., Dani, M. J. Pharm. Pharmacol. (2001) [Pubmed]
  13. Lymphatic obstruction and lymph node changes--a study of the rabbit popliteal node. Wolfe, J.H., Rutt, D., Kinmonth, J.B. Lymphology. (1983) [Pubmed]
  14. Gamma probe-guided sentinel node biopsy to select patients with melanoma for lymphadenectomy. van der Veen, H., Hoekstra, O.S., Paul, M.A., Cuesta, M.A., Meijer, S. The British journal of surgery. (1994) [Pubmed]
  15. A model for the study of coronary spasm induced changes in cardiac metabolism. Burger, W., Chemnitius, J.M., Metz, M.Z., Bing, R.J. J. Mol. Cell. Cardiol. (1985) [Pubmed]
  16. Colour lymphography in clinical surgery. Leaper, D.J., Evans, M., Pollock, A.V. The British journal of surgery. (1979) [Pubmed]
  17. Evaluation of anionic histological dyes as co-injectable cell markers in pre-implantation mouse embryos. Cruz, Y.P., Sutherland, S.A., Sutherland, J.D. Int. J. Dev. Biol. (1991) [Pubmed]
  18. Identification of sentinel lymph nodes in vulvar carcinoma patients with the aid of a patent blue V injection: a multicenter study. Ansink, A.C., Sie-Go, D.M., van der Velden, J., Sijmons, E.A., de Barros Lopes, A., Monaghan, J.M., Kenter, G.G., Murdoch, J.B., ten Kate, F.J., Heintz, A.P. Cancer (1999) [Pubmed]
  19. The effect of inguinal lymphatic manipulation on regional lymph flow patterns. Rubin, J.R., Eberlin, L.B. J. Vasc. Surg. (1993) [Pubmed]
  20. Two sulphonated dye compounds which compete for inositol 1,4, 5-trisphosphate binding to rat liver microsomes: effects on 5'-phosphatase activity. Bootman, M.D., Pay, G.F., Rick, C.E., Tones, M.A. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  21. Effects of cholesterol on dye leakage induced by multidrug-resistance modulators from anionic liposomes. Castaing, M., Loiseau, A., Djoudi, L. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2003) [Pubmed]
  22. Blood perfusion of subcutaneous tumours in mice following the application of low-level direct electric current. Jarm, T., Wickramasinghe, Y.A., Deakin, M., Cemazar, M., Elder, J., Rolfe, P., Sersa, G., Miklavcic, D. Adv. Exp. Med. Biol. (1999) [Pubmed]
  23. RT-PCR and immunohistochemical evaluation of sentinel lymph nodes after in vivo mapping with Patent Blue V in colon cancer patients. Kelder, W., Van Den Berg, A., Van Der Leij, J., Bleeker, W., Tiebosch, A.T., Grond, J.K., Baas, P.C., Plukker, J.T. Scand. J. Gastroenterol. (2006) [Pubmed]
  24. Sentinel lymph node as a new marker for therapeutic planning in breast cancer patients. Gipponi, M., Bassetti, C., Canavese, G., Catturich, A., Di Somma, C., Vecchio, C., Nicolò, G., Schenone, F., Tomei, D., Cafiero, F. Journal of surgical oncology. (2004) [Pubmed]
  25. Membrane permeation by multidrug-resistance-modulators and non-modulators: effects of hydrophobicity and electric charge. Castaing, M., Brouant, P., Loiseau, A., Santelli-Rouvier, C., Santelli, M., Alibert-Franco, S., Mahamoud, A., Barbe, J. J. Pharm. Pharmacol. (2000) [Pubmed]
  26. Sentinel lymph node biopsy in male breast cancer patients. Goyal, A., Horgan, K., Kissin, M., Yiangou, C., Sibbering, M., Lansdown, M., Newcombe, R.G., Mansel, R.E., Chetty, U., Ell, P., Fallowfield, L., Kissin, M. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2004) [Pubmed]
  27. Patent blue: a novel vital dye in vitreoretinal surgery. Mennel, S., Meyer, C.H., Tietjen, A., Rodrigues, E.B., Schmidt, J.C. Ophthalmologica (2006) [Pubmed]
  28. Sensitivity to Patent Blue dye during skin-prick testing and lymphography. A retrospective and prospective study. Kalimo, K., Jansén, C.T., Kormano, M. Radiology. (1981) [Pubmed]
  29. A new method for the visualization of subepicardial coronary arteries in small isolated mammalian hearts. Burger, W., Chemnitius, J.M., Bing, R.J. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  30. Anaphylactic reaction to patent blue V after sentinel lymph node biopsy. Dewachter, P., Mouton-Faivre, C., Benhaijoub, A., Abel-Decollogne, F., Mertes, P.M. Acta anaesthesiologica Scandinavica. (2006) [Pubmed]
  31. Identification and biopsy of the sentinel lymph node in breast cancer. Kapteijn, B.A., Nieweg, O.E., Petersen, J.L., Rutgers, E.J., Hart, A.A., van Dongen, J.A., Kroon, B.B. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (1998) [Pubmed]
  32. Radioguided occult lesion localisation (ROLL) and sentinel node biopsy for impalpable invasive breast cancer. Patel, A., Pain, S.J., Britton, P., Sinnatamby, R., Warren, R., Bobrow, L., Barber, R.W., Peters, A.M., Purushotham, A.D. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2004) [Pubmed]
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