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Disease relevance of Commiphora


High impact information on Commiphora


Biological context of Commiphora


Anatomical context of Commiphora

  • The aqueous suspension of Commiphora molmol (oleo-gum resin) has been screened for its potential to protect gastric mucosa against the ulcers caused by 80% ethanol, 25% NaCl, 0.2 M NaOH, indomethacin and combined indomethacin-ethanol treatment [12].

Associations of Commiphora with chemical compounds

  • The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL [13].
  • Dammarane triterpenes of Commiphora confusa resin [14].
  • Muscanone: a 3-O-(1", 8", 14"-trimethylhexadecanyl)naringenin from Commiphora wightii [15].
  • While no marked change in the concentrations of serum thyroxine (T4) was observed, triiodoth yronine (T3) concentration and T3/T4 ratio were enhanced following the administration of gugulu extract (0.2 g/kg b. wt./d for 15 days) [10].
  • From the resins of Commiphora kua a novel bisabolene; 6-hydroxy-2-methyl-5-(5'-hydroxy-1'(R),5'-dimethylhex-3'-enyl)-phenol together with two new dammarane triterpenes, 3beta,16beta,20(S),25-tetrahydroxydammar-23-ene and 3beta-acetoxy-16beta,20(S),25-trihydroxydammar-23-ene, have been isolated [16].

Gene context of Commiphora

  • The anticlastogenic and biochemical potentials of Commiphora molmol were studied in Swiss albino mice treated with cyclophosphamide (CP) [17].
  • In the present study, the catalytic and immunological properties of purified ASB from the liver of Schistosoma-infected mouse was investigated in the presence and absence of the schistosomicidal drugs praziquantel and Commiphora extract [18].
  • 3. Progressive decrease in the mean values of cholesterol, triglycerides and phospholipids were conspicuous for forty eight hours following the administration of guggulu/garlic powder [3].
  • In August 2003, a well-designed trial reported small significant increases in serum LDL levels associated with the use of guggul compared to placebo [Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290(6):765-72] [19].
  • Extracts of the resin of the guggul tree (Commiphora mukul) lower LDL (low-density lipoprotein) cholesterol levels in humans [20].


  1. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Ichikawa, H., Aggarwal, B.B. Clin. Cancer Res. (2006) [Pubmed]
  2. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Singh, R.B., Niaz, M.A., Ghosh, S. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1994) [Pubmed]
  3. Hypolipidemic activity of guggal resin (Commiphora mukul) and garlic (Alium sativum linn.) in dogs (Canis familiaris) and monkeys (Presbytis entellus entellus Dufresne). Dixit, V.P., Joshi, S., Sinha, R., Bharvava, S.K., Varma, M. Biochemistry and experimental biology. (1980) [Pubmed]
  4. Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Singh, S.V., Zeng, Y., Xiao, D., Vogel, V.G., Nelson, J.B., Dhir, R., Tripathi, Y.B. Mol. Cancer Ther. (2005) [Pubmed]
  5. Herbs for serum cholesterol reduction: a systematic view. Thompson Coon, J.S., Ernst, E. The Journal of family practice. (2003) [Pubmed]
  6. Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice. Kaur, G., Kulkarni, S.K. European journal of nutrition. (2001) [Pubmed]
  7. A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission. Ma, J., Jones, S.H., Hecht, S.M. J. Nat. Prod. (2005) [Pubmed]
  8. Chemical composition of the essential oil and supercritical CO2 extract of Commiphora myrrha (Nees) Engl. and of Acorus calamus L. Marongiu, B., Piras, A., Porcedda, S., Scorciapino, A. J. Agric. Food Chem. (2005) [Pubmed]
  9. Antagonism of the anticoagulant effect of warfarin caused by the use of Commiphora molmol as a herbal medication: a case report. Al Faraj, S. Ann. Trop. Med. Parasitol. (2005) [Pubmed]
  10. Gugulu (Commiphora mukul) induces triiodothyronine production: possible involvement of lipid peroxidation. Panda, S., Kar, A. Life Sci. (1999) [Pubmed]
  11. Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF-alpha, IL-1beta and IL-2. Manjula, N., Gayathri, B., Vinaykumar, K.S., Shankernarayanan, N.P., Vishwakarma, R.A., Balakrishnan, A. Int. Immunopharmacol. (2006) [Pubmed]
  12. Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats. al-Harbi, M.M., Qureshi, S., Raza, M., Ahmed, M.M., Afzal, M., Shah, A.H. Journal of ethnopharmacology. (1997) [Pubmed]
  13. The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Wang, X., Greilberger, J., Ledinski, G., Kager, G., Paigen, B., Jürgens, G. Atherosclerosis (2004) [Pubmed]
  14. Dammarane triterpenes of Commiphora confusa resin. Manguro, L.O., Ugi, I., Lemmen, P. Chem. Pharm. Bull. (2003) [Pubmed]
  15. Muscanone: a 3-O-(1", 8", 14"-trimethylhexadecanyl)naringenin from Commiphora wightii. Fatope, M.O., Al-Burtomani, S.K., Ochei, J.O., Abdulnour, A.O., Al-Kindy, S.M., Takeda, Y. Phytochemistry (2003) [Pubmed]
  16. Further bisabolenes and dammarane triterpenes of Commiphora kua resin. Manguro, L.O., Ugi, I., Lemmen, P. Chem. Pharm. Bull. (2003) [Pubmed]
  17. Effect of Commiphora molmol (oleo-gum-resin) on the cytological and biochemical changes induced by cyclophosphamide in mice. al-Harbi, M.M., Qureshi, S., Ahmed, M.M., Rafatullah, S., Shah, A.H. Am. J. Chin. Med. (1994) [Pubmed]
  18. In vitro effect of schistosomicidal drugs on hepatic arylsulfatase B from the schistosoma-infected mouse. Balbaa, M., Bassiouny, K. Journal of enzyme inhibition and medicinal chemistry. (2006) [Pubmed]
  19. Guggul for hyperlipidemia: a review by the Natural Standard Research Collaboration. Ulbricht, C., Basch, E., Szapary, P., Hammerness, P., Axentsev, S., Boon, H., Kroll, D., Garraway, L., Vora, M., Woods, J. Complementary therapies in medicine. (2005) [Pubmed]
  20. A natural product that lowers cholesterol as an antagonist ligand for FXR. Urizar, N.L., Liverman, A.B., Dodds, D.T., Silva, F.V., Ordentlich, P., Yan, Y., Gonzalez, F.J., Heyman, R.A., Mangelsdorf, D.J., Moore, D.D. Science (2002) [Pubmed]
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