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Chemical Compound Review

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Disease relevance of Rulide


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High impact information on Rulide


Chemical compound and disease context of Rulide


Biological context of Rulide

  • Roxithromycin enhances lymphocyte apoptosis in Dermatophagoides-sensitive childhood asthma [15].
  • CONCLUSIONS: Our results indicate that roxithromycin inhibits oxidative stress, nitric oxide production, and nuclear factor kappaB activation induced by experimental hepatocarcinogenesis [16].
  • Medication was given as follows: (1) cycle 1, no medication to demonstrate ovulation; (2) cycle 2, triphasic oral contraceptive daily to suppress ovulation; (3) cycle 3, triphasic oral contraceptive daily plus roxithromycin, 150 mg b.i.d.; and (4) cycle 4, triphasic oral contraceptive daily plus rifampin, 300 mg daily [17].
  • Pharmacokinetics and tissue penetration of roxithromycin after multiple dosing [18].
  • Entry of roxithromycin into phagocytes was an active process and displayed saturation kinetics characteristic of a carrier-mediated membrane transport system [19].

Anatomical context of Rulide


Associations of Rulide with other chemical compounds


Gene context of Rulide


Analytical, diagnostic and therapeutic context of Rulide


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  11. Activity of HMR 3647 compared to those of six compounds against 235 strains of Enterococcus faecalis. Hoellman, D.B., Lin, G., Jacobs, M.R., Appelbaum, P.C. Antimicrob. Agents Chemother. (1999) [Pubmed]
  12. In vitro activity of Ro 15-8074, Ro 19-5247, A-56268, and roxithromycin (RU 28965) against Neisseria gonorrhoeae and Chlamydia trachomatis. Bowie, W.R., Shaw, C.E., Chan, D.G., Black, W.A. Antimicrob. Agents Chemother. (1987) [Pubmed]
  13. In vitro activities of new macrolides and rifapentine against Brucella spp. García-Rodríguez, J.A., Muñoz Bellido, J.L., Fresnadillo, M.J., Trujillano, I. Antimicrob. Agents Chemother. (1993) [Pubmed]
  14. Effect of telithromycin (HMR 3647) on polymorphonuclear neutrophil killing of Staphylococcus aureus in comparison with roxithromycin. Vazifeh, D., Abdelghaffar, H., Labro, M.T. Antimicrob. Agents Chemother. (2002) [Pubmed]
  15. Roxithromycin enhances lymphocyte apoptosis in Dermatophagoides-sensitive childhood asthma. Noma, T., Ogawa, N. J. Allergy Clin. Immunol. (2003) [Pubmed]
  16. Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma. Ueno, S., Aoki, D., Kubo, F., Hiwatashi, K., Matsushita, K., Oyama, T., Maruyama, I., Aikou, T. Clin. Cancer Res. (2005) [Pubmed]
  17. A model to detect interactions between roxithromycin and oral contraceptives. Meyer, B., Müller, F., Wessels, P., Maree, J. Clin. Pharmacol. Ther. (1990) [Pubmed]
  18. Pharmacokinetics and tissue penetration of roxithromycin after multiple dosing. Wise, R., Kirkpatrick, B., Ashby, J., Andrews, J.M. Antimicrob. Agents Chemother. (1987) [Pubmed]
  19. Entry of roxithromycin (RU 965), imipenem, cefotaxime, trimethoprim, and metronidazole into human polymorphonuclear leukocytes. Hand, W.L., King-Thompson, N., Holman, J.W. Antimicrob. Agents Chemother. (1987) [Pubmed]
  20. Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. Struillou, L., Cohen, Y., Lounis, N., Bertrand, G., Grosset, J., Vildé, J.L., Pocidalo, J.J., Perronne, C. Antimicrob. Agents Chemother. (1995) [Pubmed]
  21. In vitro effects of ciprofloxacin and roxithromycin on apoptosis of jurkat T lymphocytes. Jun, Y.T., Kim, H.J., Song, M.J., Lim, J.H., Lee, D.G., Han, K.J., Choi, S.M., Yoo, J.H., Shin, W.S., Choi, J.H. Antimicrob. Agents Chemother. (2003) [Pubmed]
  22. Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro. Kawasaki, S., Takizawa, H., Ohtoshi, T., Takeuchi, N., Kohyama, T., Nakamura, H., Kasama, T., Kobayashi, K., Nakahara, K., Morita, Y., Yamamoto, K. Antimicrob. Agents Chemother. (1998) [Pubmed]
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  24. Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin. Vazifeh, D., Abdelghaffar, H., Labro, M.T. Antimicrob. Agents Chemother. (1997) [Pubmed]
  25. Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. Wenisch, C., Parschalk, B., Zedtwitz-Liebenstein, K., Weihs, A., el Menyawi, I., Graninger, W. Antimicrob. Agents Chemother. (1996) [Pubmed]
  26. Clindamycin, erythromycin, and roxithromycin inhibit the proinflammatory interactions of Pseudomonas aeruginosa pigments with human neutrophils in vitro. Ras, G.J., Anderson, R., Taylor, G.W., Savage, J.E., van Niekerk, E., Joone, G., Koornhof, H.J., Saunders, J., Wilson, R., Cole, P.J. Antimicrob. Agents Chemother. (1992) [Pubmed]
  27. Differential modulation of cytokine production by macrolides: interleukin-6 production is increased by spiramycin and erythromycin. Bailly, S., Pocidalo, J.J., Fay, M., Gougerot-Pocidalo, M.A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  28. Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. Yamazaki, H., Shimada, T. Drug Metab. Dispos. (1998) [Pubmed]
  29. Roxithromycin inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-1 expression through regulating mitogen-activated protein kinase phosphorylation and Ets-1 expression. Oyama, T., Matsushita, K., Sakuta, T., Tokuda, M., Tatsuyama, S., Nagaoka, S., Torii, M. J. Periodont. Res. (2007) [Pubmed]
  30. Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture. Stamm, W.E., Suchland, R. Antimicrob. Agents Chemother. (1986) [Pubmed]
  31. Effects of roxithromycin on fecal bacteria in human volunteers and resistance to colonization in gnotobiotic mice. Pecquet, S., Chachaty, E., Tancrède, C., Andremont, A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  32. A randomized trial of roxithromycin in patients with acute leukemia and bone marrow transplant recipients receiving fluoroquinolone prophylaxis. Kern, W.V., Hay, B., Kern, P., Marre, R., Arnold, R. Antimicrob. Agents Chemother. (1994) [Pubmed]
  33. In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62,993], and A-56268) on Toxoplasma gondii. Chang, H.R., Pechère, J.C. Antimicrob. Agents Chemother. (1988) [Pubmed]
  34. Roxithromycin disposition in tonsils after single and repeated administrations. Galioto, G.B., Ortisi, G., Mevio, E., Sassella, D., Bartucci, F., Privitera, G. Antimicrob. Agents Chemother. (1988) [Pubmed]
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