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Gene Review

Edn1  -  endothelin 1

Mus musculus

Synonyms: ET-1, Endothelin-1, PPET1, Preproendothelin-1, preproET
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Disease relevance of Edn1


Psychiatry related information on Edn1

  • The results suggest that there is a basal release of ET-1 from neurons that affect baseline pain thresholds as well as an additional release during persistent pain states that acts to suppress the pain [6].
  • ET-1 and ET-3 produced central depressive effects demonstrated by depressive behavior signs, decrease of the spontaneous and amphetamine-stimulated motor activity, and prolongation of the hexobarbital-induced narcosis [7].
  • In addition, since ET-antagonists lowered per se the control reaction time of the mice when administered alone to the PAG area, we would suggest that endogenous ET-1 acting within the PAG area contributes to the suppression of pain [8].

High impact information on Edn1

  • Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons [9].
  • These findings indicate that interaction of EDN3 with the endothelin-B receptor is essential in the development of neural crest-derived cell lineages [9].
  • Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon and pigmentary disorders in mice and humans [9].
  • However, there is evidence that the initial phase in the development of myocardial hypertrophy involves the formation of cardiac para- and/or autocrine factors like endothelin-1, norepinephrine or angiotensin II (refs. 7,8), the receptors of which are coupled to G-proteins of the Gq/11-, G12/13- and Gi/o-families [10].
  • The temporal requirement for endothelin receptor-B signalling during neural crest development [11].

Chemical compound and disease context of Edn1


Biological context of Edn1


Anatomical context of Edn1


Associations of Edn1 with chemical compounds


Physical interactions of Edn1


Enzymatic interactions of Edn1


Regulatory relationships of Edn1


Other interactions of Edn1


Analytical, diagnostic and therapeutic context of Edn1


  1. Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene. Maemura, K., Kurihara, H., Kurihara, Y., Oda, H., Ishikawa, T., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Yazaki, Y. Genomics (1996) [Pubmed]
  2. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Barton, M., Haudenschild, C.C., d'Uscio, L.V., Shaw, S., Münter, K., Lüscher, T.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Endothelin-1 protects astrocytes from hypoxic/ischemic injury. Ho, M.C., Lo, A.C., Kurihara, H., Yu, A.C., Chung, S.S., Chung, S.K. FASEB J. (2001) [Pubmed]
  4. Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. Spinella, F., Rosanò, L., Di Castro, V., Nicotra, M.R., Natali, P.G., Bagnato, A. J. Biol. Chem. (2003) [Pubmed]
  5. Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice. Nakamura, T., Ebihara, I., Fukui, M., Osada, S., Tomino, Y., Masaki, T., Goto, K., Furuichi, Y., Koide, H. J. Am. Soc. Nephrol. (1993) [Pubmed]
  6. Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice. Hasue, F., Kuwaki, T., Kisanuki, Y.Y., Yanagisawa, M., Moriya, H., Fukuda, Y., Shimoyama, M. Neuroscience (2005) [Pubmed]
  7. Central effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) in mice. Maslarova, J., Getova, D., Semkova, I., Nikolov, R. Methods and findings in experimental and clinical pharmacology. (1995) [Pubmed]
  8. Selective and non-selective ET antagonists reveal an ET(A)/ET(B) receptor mediated ET-1-induced antinociceptive effect in PAG area of mice. D'Amico, M., Di Filippo, C., Rossi, F. Life Sci. (1997) [Pubmed]
  9. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Baynash, A.G., Hosoda, K., Giaid, A., Richardson, J.A., Emoto, N., Hammer, R.E., Yanagisawa, M. Cell (1994) [Pubmed]
  10. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Wettschureck, N., Rütten, H., Zywietz, A., Gehring, D., Wilkie, T.M., Chen, J., Chien, K.R., Offermanns, S. Nat. Med. (2001) [Pubmed]
  11. The temporal requirement for endothelin receptor-B signalling during neural crest development. Shin, M.K., Levorse, J.M., Ingram, R.S., Tilghman, S.M. Nature (1999) [Pubmed]
  12. Regulation of adiponectin secretion by endothelin-1. Clarke, K.J., Zhong, Q., Schwartz, D.D., Coleman, E.S., Kemppainen, R.J., Judd, R.L. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  13. Renal expression of mRNAs for endothelin-1, endothelin-3 and endothelin receptors in NZB/W F1 mice. Nakamura, T., Ebihara, I., Fukui, M., Osada, S., Tomino, Y., Masaki, T., Goto, K., Furuichi, Y., Koide, H. Renal physiology and biochemistry. (1993) [Pubmed]
  14. Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. Getting, S.J., Di Filippo, C., Lam, C.W., Rossi, F., D'Amico, M. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  15. Endothelin-elicited stimulation of phospholipase C is mediated by guanine nucleotide binding protein(s). Gusovsky, F. Eur. J. Pharmacol. (1992) [Pubmed]
  16. Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice. Maemura, K., Kurihara, H., Kurihara, Y., Kuwaki, T., Kumada, M., Yazaki, Y. J. Cardiovasc. Pharmacol. (1995) [Pubmed]
  17. Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization. Kitano, Y., Kurihara, H., Kurihara, Y., Maemura, K., Ryo, Y., Yazaki, Y., Harii, K. J. Bone Miner. Res. (1998) [Pubmed]
  18. Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish. Nair, S., Li, W., Cornell, R., Schilling, T.F. Development (2007) [Pubmed]
  19. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa, H., Hammer, R.E., Richardson, J.A., Williams, S.C., Clouthier, D.E., Yanagisawa, M. J. Clin. Invest. (1998) [Pubmed]
  20. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. Imamura, T., Huang, J., Dalle, S., Ugi, S., Usui, I., Luttrell, L.M., Miller, W.E., Lefkowitz, R.J., Olefsky, J.M. J. Biol. Chem. (2001) [Pubmed]
  21. IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-gamma, endothelin, and prostaglandin. Verri, W.A., Cunha, T.M., Parada, C.A., Wei, X.Q., Ferreira, S.H., Liew, F.Y., Cunha, F.Q. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  22. A direct effect of aldosterone on endothelin-1 gene expression in vivo. Wong, S., Brennan, F.E., Young, M.J., Fuller, P.J., Cole, T.J. Endocrinology (2007) [Pubmed]
  23. Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice. Dettlaff-Swiercz, D.A., Wettschureck, N., Moers, A., Huber, K., Offermanns, S. Dev. Biol. (2005) [Pubmed]
  24. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a neuropeptide antagonist, blocks binding, Ca2(+)-mobilizing, and mitogenic effects of endothelin and vasoactive intestinal contractor in mouse 3T3 cells. Fabregat, I., Rozengurt, E. J. Cell. Physiol. (1990) [Pubmed]
  25. The expression of endothelin-1 and its binding sites in mouse skin increased after ultraviolet B irradiation or local injection of tumor necrosis factor alpha. Ahn, G.Y., Butt, K.I., Jindo, T., Yaguchi, H., Tsuboi, R., Ogawa, H. J. Dermatol. (1998) [Pubmed]
  26. Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors. Mao, J., Yuan, H., Xie, W., Simon, M.I., Wu, D. J. Biol. Chem. (1998) [Pubmed]
  27. Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro. Kubes, M., Cordier, J., Glowinski, J., Girault, J.A., Chneiweiss, H. J. Neurochem. (1998) [Pubmed]
  28. Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes. Mérial-Kieny, C., Lonchampt, M., Cogé, F., Verwaerde, P., Galizzi, J.P., Boutin, J.A., Lafontan, M., Levens, N., Galitzky, J., Félétou, M. Br. J. Pharmacol. (2003) [Pubmed]
  29. Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction. Hassan, G.S., Williams, T.M., Frank, P.G., Lisanti, M.P. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  30. Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism. Bedi, D., Clarke, K.J., Dennis, J.C., Zhong, Q., Brunson, B.L., Morrison, E.E., Judd, R.L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  31. Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production. Herrera, M., Hong, N.J., Ortiz, P.A., Garvin, J.L. J. Biol. Chem. (2009) [Pubmed]
  32. Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reaction analysis in adult mouse tissues and during late embryonic development. Uchide, T., Masuda, H., Mitsui, Y., Saida, K. J. Mol. Endocrinol. (1999) [Pubmed]
  33. Interleukin-1beta attenuates endothelin B receptor-mediated airway contractions in a murine in vitro model of asthma: roles of endothelin converting enzyme and mitogen-activated protein kinase pathways. Zhang, Y., Adner, M., Cardell, L.O. Clin. Exp. Allergy (2004) [Pubmed]
  34. ET-1-induced bronchoconstriction is mediated via ETB receptor in mice. Nagase, T., Aoki, T., Oka, T., Fukuchi, Y., Ouchi, Y. J. Appl. Physiol. (1997) [Pubmed]
  35. Amelioration of cyclosporin A effect on microvasculature by endothelin inhibitor. Wilasrusmee, C., Ondocin, P., Bruch, D., Shah, G., Kittur, S., Wilasrusmee, S., Kittur, D.S. Surgery (2003) [Pubmed]
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