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Chemical Compound Review

INDOPHENOL     4-(4- hydroxyphenyl)iminocyclohexa- 2,5-dien...

Synonyms: SureCN35153, AG-F-68019, CHEBI:50428, I5763_SIGMA, KB-52688, ...
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Disease relevance of INDOPHENOL


High impact information on INDOPHENOL

  • We show that an indophenol-based colorimetric method for acetaminophen (Clin Toxicol 15: 67-73, 1979) has less than maximal sensitivity because of (a) incomplete hydrolysis, related to suboptimal acid concentration; (b) suboptimal hydrolysis time; and (c) possible deterioration of the ammonium hydroxide reagent after 2.5 months [4].
  • A sensitive, optimized assay for serum AMP deaminase (EC is presented, which is based on a colorimetric indophenol determination of ammonia liberated during the enzyme reaction [5].
  • These isolates were gram-negative, oxidative rods which were motile by means of a single polar flagellum; gave positive catalase, indophenol oxidase, urease, and amylase reactions; and grew slowly at 30 degrees C. Fourteen isolates conformed to the designated type strains Pseudomonas mesophilica ATCC 29983 and Protaminobacter ruber ATCC 8457 [6].
  • Two isolates of Pseudomonas aeruginosa lacking characteristic indophenol oxidase were recovered from a sputum specimen [7].
  • 2,6-Dichloro-phenol indophenol prevents switch-over of electrons between the cyanide-sensitive and -insensitive pathway of the mitochondrial electron transport chain in the presence of inhibitors [8].

Biological context of INDOPHENOL


Anatomical context of INDOPHENOL


Associations of INDOPHENOL with other chemical compounds


Gene context of INDOPHENOL

  • Urea produced by arginase was hydrolyzed to ammonia by urease, the ammonia was converted to indophenol, and the absorbance was measured at 570 nm [16].
  • In reverse micelles, some inhibitors of AChE (propidium, and d-tubocurarine) have much less effect upon indophenol-acetate hydrolysis than they do in a dilute solution environment [17].

Analytical, diagnostic and therapeutic context of INDOPHENOL

  • Analysis is carried out in end-point samples by Winkler's titration and indophenol-blue for oxygen and ammonia-N, respectively [18].


  1. Isolation of oxidase-negative Pseudomonas aeruginosa from urine culture. McCleskey, F.K., Adams, E.D. J. Clin. Microbiol. (1980) [Pubmed]
  2. Arterial ammonia with Blood Ammonia Checker II and with indophenol reaction to assess presence of hepatic encephalopathy. Huizenga, J.R., van Dam, G.M., Gips, C.H. Clin. Chim. Acta (1996) [Pubmed]
  3. Plesiomonas (Aeromonas) shigelloides septicemia and meningitis in a neonate. Dahm, L.J., Weinberg, A.G. South. Med. J. (1980) [Pubmed]
  4. Indophenol method for acetaminophen in serum examined. Novotny, P.E., Elser, R.C. Clin. Chem. (1984) [Pubmed]
  5. Sensitive, optimized assay for serum AMP deaminase. Pedersen, R.C., Berry, A.J. Clin. Chem. (1977) [Pubmed]
  6. Pseudomonas mesophilica and an unnamed taxon, clinical isolates of pink-pigmented oxidative bacteria. Gilardi, G.L., Faur, Y.C. J. Clin. Microbiol. (1984) [Pubmed]
  7. Isolation of oxidase-negative Pseudomonas aeruginosa from sputum culture. Hampton, K.D., Wasilauskas, B.L. J. Clin. Microbiol. (1979) [Pubmed]
  8. 2,6-Dichloro-phenol indophenol prevents switch-over of electrons between the cyanide-sensitive and -insensitive pathway of the mitochondrial electron transport chain in the presence of inhibitors. Kumar, S., Acharya, S.K. Anal. Biochem. (1999) [Pubmed]
  9. Multilocus enzyme analysis of the genus Aeromonas and its use for species identification. Altwegg, M., Reeves, M.W., Altwegg-Bissig, R., Brenner, D.J. Zentralbl. Bakteriol. (1991) [Pubmed]
  10. The role of chloride ion on the photoreactivation of the oxygen-evolving center of tris-washed, 2,6-dichlorophenol indophenol-treated grana. Yamashita, T., Ashizawa, A. Arch. Biochem. Biophys. (1985) [Pubmed]
  11. Determination of ammonia in cerebrospinal fluid using the indophenol direct method. Huizenga, J.R., Teelken, A.W., Tangerman, A., de Jager, A.E., Gips, C.H., Jansen, P.L. Mol. Chem. Neuropathol. (1998) [Pubmed]
  12. Redox reactions of tonoplast and plasma membranes isolated from soybean hypocotyls by free-flow electrophoresis. Barr, R., Sandelius, A.S., Crane, F.L., Morré, D.J. Biochim. Biophys. Acta (1986) [Pubmed]
  13. Spectrophotometric determination of oxyphenbutazone in drug formulations using the indophenol reaction. Verma, K.K., Jain, A. The Analyst. (1985) [Pubmed]
  14. Assays for allantoinase. Romanov, V., Merski, M.T., Hausinger, R.P. Anal. Biochem. (1999) [Pubmed]
  15. Sensitivity improvement of ammonia determination based on flow-injection indophenol spectrophotometry with manganese(II) ion as a catalyst and analysis of exhaust gas of thermal power plant. Tsuboi, T., Hirano, Y., Shibata, Y., Motomizu, S. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2002) [Pubmed]
  16. Assay and kinetics of arginase. Garganta, C.L., Bond, J.S. Anal. Biochem. (1986) [Pubmed]
  17. Reverse-micelle model: pH, electromagnetic field and inhibitor enzyme interaction. Chattopadhyay, S.K., Toews, K.A., Butt, S., Barlett, R., Brown, H.D. Cancer Biochem. Biophys. (1997) [Pubmed]
  18. Simultaneous measurements of oxygen consumption and ammonia-N excretion in embryos and larvae of marine invertebrates. Lemos, D., Jorge, R.L., Phan, V.N. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2003) [Pubmed]
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